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Giguère S Cohen ND Chaffin MK Hines SA Hondalus MK Prescott JF Slovis NM 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2011,25(6):1221-1230
Pneumonia is a major cause of disease and death in foals. Rhodococcus equi, a gram-positive facultative intracellular pathogen, is a common cause of pneumonia in foals. This article reviews the clinical manifestations of infection caused by R. equi in foals and summarizes current knowledge regarding mechanisms of virulence of, and immunity to, R. equi. A complementary consensus statement providing recommendations for the diagnosis, treatment, control, and prevention of infections caused by R. equi in foals can be found in the same issue of the Journal. 相似文献
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Lack of Detectable Equine Herpesviruses 1 and 2 in Paraffin-Embedded Specimens of Equine Sarcoidosis
S.D. White J.E. Foley I.B. Spiegel P.J. Ihrke 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2009,23(3):623-625
Background: Equine sarcoidosis is a rare, multisystemic, noncaseating, granulomatous and lymphoplasmacytic disease of unknown etiology. A recent report described a horse with granulomatous skin disease displaying histologic, electron microscopic, and polymerase chain reaction (PCR) findings consistent with equine herpesvirus 2 (EHV-2).
Objective: To investigate the presence of EHV-2 and equine herpesvirus 1 (EHV-1) in 8 horses with sarcoidosis.
Animals: Eight horses with sarcoidosis, reported previously.
Methods: Retrospective study. PCR assays of the tissues were performed to detect DNA associated with EHV-1 and EHV-2. For both herpesviruses the target was their respective glycoprotein B gene. Positive controls consisted of DNA from viral cultures of culturettes from naturally occurring respiratory infections of EHV-1 and EHV-2.
Results: The PCR analyses for both equine herpesviruses' DNA were negative in all 8 horses.
Conclusion: The failure to detect DNA from EHV-1 and EHV-2 in paraffin-embedded skin of these 8 horses does not discount EHV-1 or EHV-2 as causing some cases of ES, but lends support to the presumably multifactorial etiologic nature of the disease. 相似文献
Objective: To investigate the presence of EHV-2 and equine herpesvirus 1 (EHV-1) in 8 horses with sarcoidosis.
Animals: Eight horses with sarcoidosis, reported previously.
Methods: Retrospective study. PCR assays of the tissues were performed to detect DNA associated with EHV-1 and EHV-2. For both herpesviruses the target was their respective glycoprotein B gene. Positive controls consisted of DNA from viral cultures of culturettes from naturally occurring respiratory infections of EHV-1 and EHV-2.
Results: The PCR analyses for both equine herpesviruses' DNA were negative in all 8 horses.
Conclusion: The failure to detect DNA from EHV-1 and EHV-2 in paraffin-embedded skin of these 8 horses does not discount EHV-1 or EHV-2 as causing some cases of ES, but lends support to the presumably multifactorial etiologic nature of the disease. 相似文献
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《免疫学》是一门理论性、实践性都很强的学科,内容抽象,逻辑性强,教学难度大。因此,提高学生的学习兴趣,采用PBL教学方法和比喻教学方法,以及引入现代化的多媒体教学手段,注重实验教学,对提高免疫学的教学质量至关重要。 相似文献
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Gry Jaeger Hege Kippenes Skogmo ?yvor Kolbj?rnsen Hans J?rgen S?iland Larsen Bjarne Bergsj? Henning S?rum 《Acta veterinaria Scandinavica》2013,55(1):67
In spite of yearly vaccination, outbreaks of canine infectious respiratory disease are periodically seen amongst domestic dogs. These infections compromise host defense mechanisms, and, when combined with other stressful events, allow opportunistic pathogens like Streptococcus equi subsp. zooepidemicus to create serious disease. Early recognition and treatment are tremendously important for a successful outcome in these cases. A polyvalent vaccine was given to 22 racing dogs three days after a competition, followed by two days of rest, and then the dogs were returned to regular training. Coughing was noticed among the dogs four days after immunisation. Three days after this outbreak one of the dogs was unusually silent and was found dead the next morning. Simultaneously two other dogs developed haemorrhagic expectorate, depression and dyspnea and were brought in to the veterinary hospital. Streptococcus equi subsp. zooepidemicus was isolated in pure culture from all three cases. They were treated and rehabilitated successfully, and won a sledge race three months later. This paper discusses the necropsy results, treatment regime, rehabilitation and the chronology of vaccination, stressful events and disease. 相似文献
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Summary Following concomitant intravenous administration of Tomanol® and sodium penicillin G to six Dutch Friesian dairy cows a significant decrease in total body clearance of penicillin (34.7%) and a prolongation of the elimination half‐life of penicillin (17.2%) was observed. Tomanol® did not affect other pharmacokinetic parameters such as rate constants of drug transfer (k12/k21, α en β), distribution volume of the central compartment (V1), and extrapolated serum drug levels. Intravenous or intramuscular administration of Tomanol® had no effect on the tissue distribution of penicillin G, because neither a change in the ratios of muscle to serum and of kidney cortex to serum nor a change in an induced steady state level of low penicilline G serum concentrations was observed. From the data obtained it is concluded that concomitant Tomanol® administration with penicillin induces an elevation of the serum penicillin concentration and prolongs the persistence of penicillin residues in carcass meat and organs. 相似文献
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M. Nofrarías E.G. Manzanilla J. Pujols X. Gibert N. Maj J. Segals J. Gasa 《Livestock Science》2007,108(1-3):299-302
The aim of this study was to evaluate the effects of dietary spray-dried porcine plasma (SDPP) on the productive performance, intestinal morphology and leukocyte cell subsets of piglets. Sixteen early-weaned piglets (20 ± 2 d) were distributed into two dietary treatments: 1) free access to control diet or 2) 6% SDPP in the control diet instead of soy-protein concentrate. Intestinal morphometry of the small and large intestine, haematology and immune cell flow cytometric analysis of blood, ileo-colic lymph node and ileal Peyer's patches were performed in all pigs. Although SDPP treatment did not increase growth performance, it improved feed efficiency. We observed that SDPP diminishes blood monocytes, and macrophages (SWC3+), B lymphocytes (CD21+) and γδ T cells (γδTCR+) in gut lymphoid tissues. SDPP-treated piglets also showed lower intraepithelial lymphocyte numbers and lamina propria cell density in the small and large intestine. All these results suggest lower activation of the immune system of the SDPP-piglets during the post-weaning period. Moreover, the use of SDPP can be considered a valid alternative to antibiotic growth promoters. 相似文献
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