幽门螺杆菌与胃、十二指肠疾病

将有关幽门螺杆菌(helicobacterpylori HP)的感染途径、致病机理、临床特点、治疗方案加以总结。分析幽门螺杆菌与胃、十二指肠溃疡、胃癌的关联。     

Herd and cow-level prevalence of sole ulcers in The Netherlands and associated-risk factors

A cross-sectional study was performed, to (re)evaluate the prevalence of sole ulcers (SUs) and the risk factors involved in dairy herds that perform claw trimming on a routine base. Twenty hoof trimmers collected data on the presence or absence of claw disorders on the hind claws of dairy cows during whole herd trimming in 383 herds in The Netherlands. A questionnaire was used to acquire information on management and housing. Additional data on parity, breed and stage of lactation of the cows were provided by the Dutch Herd Book Organization.

Sole ulcer was present in 85% of the herds and in 5.6% (S.E. 0.2) of the study population (n = 22,454 cows). The within-herd prevalence varied from 0% (14.6% of herds) to 26% (0.3% of herds) and in herds with SU was most frequently diagnosed 1–5% of the trimmed cows (45% of all herds).

The risk for SU increased significantly with increasing parity. Cows that were at or after peak of lactation (>60 days in milk, DIM) had higher odds on SU in comparison to cows that were between 0 and 60 DIM (OR = 0.6).

The presence of other non-infectious claw disorders appeared to predispose to SU. Based on an estimation of the population attributable fraction, it was concluded that if sole hemorrhages, chronic laminitis (CL), white line disease and interdigital hyperplasia were the cause of SU and if those diseases could have been prevented in the study population, 35.4, 5.8, 11.6 and 4.6% of the SU cases respectively could have been prevented. Because of this relation, an effective intervention strategy of SU should focus on an integral approach of reducing the first stages of the bovine laminitis complex, whereas SU and CL are considered to be a later stage.

Cows trimmed during late summer were at a higher risk for SU than cows trimmed in other periods of the year. Finally, cows in herds with purchased heifers were at a higher risk (OR = 1.4) for SU than cows in herds that did not purchase heifers. A comparable positive effect was visible in herds with mattress bedding.     

埃索美拉唑与奥美拉唑三联疗法治疗十二指肠球部溃疡的愈合率及Hp根除率比较

目的:观察埃索美拉唑、奥美拉唑三联疗法两周治疗十二指肠球部溃疡的愈合率及Hp根除率比较。方法:幽门螺杆菌(Hp)阳性的十二肠球部溃疡A1期患者113例随机分为两组:埃索美拉唑组57例,奥美拉唑组56例。两组均先给予三联治疗(埃索美拉唑20mg或奥美拉唑20mg 阿莫西林lg 克拉霉素500mg,2次/d),连续7d,然后分别单独给予埃索美拉唑20mg(1次/d)或奥美拉唑20mg(1次/d)7d,停药后4～6周复查内镜并检测Hp,观察溃疡的愈合情况及Hp根除率。结果:埃索美拉唑组d1和d2腹痛缓解率分别为35.1%和61.4%,高于奥美拉唑组的16.1%和37.5%(P<0.05)。埃索美拉唑组和奥美拉唑组2周溃疡愈合率分别为93.0%和80.4%,差异有统计学意义(P<0.05)。Hp根除率分别为89.5%和80.4%,差异无统计学意义(P>0.05)。结论:埃索美拉唑三联疗法2周治疗十二指肠球部溃疡在缓解腹痛及溃疡愈合率均优于奥美拉唑。     

海南西培农场橡胶树条溃疡病发生规律及防治经验总结

对海南省西培农场橡胶树条溃疡病的发生和流行规律,以及防治经验进行总结,以期引起生产者在生产实践中对该病害的重视。     

Bacteroides sp. as a cause of anaerobic keratitis in a pony

This Case Report describes anaerobic infection of the conjunctiva and cornea in a pony. A 13‐year‐old pony was admitted for evaluation following suspected ocular trauma. Bacterial conjunctivitis and keratitis were diagnosed based on clinical appearance of the eye and cytological evaluation of a corneal scraping. The pony responded poorly to topical therapy, and enucleation was performed. Culture of the corneal scraping yielded Corynebacterium sp. and Bacteroides sp. Anaerobic keratitis and conjunctivitis is uncommonly reported in horses, but should be suspected when there is a history of ocular trauma or skin disease, or when a malodorous ocular discharge is identified.