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11.
PC Jimenez DV Wilke EG Ferreira R Takeara MO de Moraes ER da Silveira TM da Cruz Lotufo NP Lopes LV Costa-Lotufo 《Marine drugs》2012,10(5):1092-1102
The present study reports the identification of two new staurosporine derivatives, 2-hydroxy-7-oxostaurosporine (1) and 3-hydroxy-7-oxostaurosporine (2), obtained from mid-polar fractions of an aqueous methanol extract of the tunicate Eudistoma vannamei, endemic to the northeast coast of Brazil. The mixture of 1 and 2 displayed IC50 values in the nM range and was up to 14 times more cytotoxic than staurosporine across a panel of tumor cell lines, as evaluated using the MTT assay. 相似文献