壳聚糖胶囊大鼠30天喂养试验研究

[目的]观察壳聚糖胶囊30 d喂养大鼠产生的毒性。[方法]设低（0.83 g/kg·bw）、中（1.67 g/kg·bw）、高（3.33g/kg·bw）剂量组与对照组,连续喂养大鼠30 d观察动物生长发育状况、体重变化、平均进食量,计算食物利用率、脏器重量及脏器/体重比值,分析血常规指标和血生化指标,并进行大体解剖和组织病理分析。[结果]30 d喂养试验期间,动物生长发育良好,各指标与对照组比较无显著性差异（P＞0.05）。大体解剖和组织病理分析未见与样品有关的异常改变。[结论]样品30 d喂养对大鼠未产生明显毒副作用。     

熏蒸剂磷化氢的研究进展

较为全面地概述了熏蒸剂磷化氢的毒理学及昆虫抗药性相关研究的最新进展,着重介绍了昆虫对磷化氢的吸收、磷化氢的作用靶点、昆虫的不同种类及不同虫态对药剂的反应等,同时介绍了对磷化氢产生抗药性的仓库昆虫种类、抗药性表现以及治理的对策。     

灵芝康泰粉剂抑制肿瘤的作用及其安全性研究

以灵芝子实体有效成分复配的灵芝康泰粉剂,对荷动物S-180实体瘤与EAC腹水瘤的雌雄小鼠进行肿瘤抑制试验.口服0.5g/kg@day和1.5g/kg@day灵芝康泰粉剂能明显抑制动物S-180实体瘤的生长,延长EAC腹水瘤动物的平均生存时间,对S-180的抑瘤率为41.22%～41.30%和45 65%～50.00%.急性毒性试验表明,灵芝康泰粉剂对雌雄小鼠的经口LD50均大于10g/kg,微核试验和Ames试验均为阴性,未见致突变性.30d喂养试验发现,灵芝康泰粉剂对试验动物的生长发育无不良影响.     

The future of veterinary therapeutics: a glimpse towards 2030

The purpose of this article is to make an educated guess as to what veterinary pharmacology will look like in two decades. By examining the past, it is evident that change is incremental unless a transforming discovery occurs. In the last few decades, such events have dramatically changed medicine and pharmacology, however they have not percolated through the system to the effect that novel drugs have replaced our traditional armamentarium. The effect of six transforming technologies (continued advances in computer technology, microfluidics, nanotechnology, high-throughput screening, control and targeted drug delivery, pharmacogenomics) on veterinary therapeutics is examined. These should lead toward more efficacious and safer drugs across most therapeutic classes due to both increases in our knowledge base as well as more efficient drug development. Shorter term improvements in drug delivery should be seen. Although this growth in technology would portend major advances over the next few decades, economic and regulatory constraints must still be overcome for these new drugs or therapeutic approaches to become common practice.     

《食品毒理学》课程的教学改革探索简

探讨了食品毒理学教学中存在的主要问题,并从教学内容、教学手段等方面探索了如何在教学中体现食品专业的特色,提高教学质量,为我国的食品质量与安全专业培养合格的人才.     

贵州白虫茶生物安全性毒理学评价研究

[目的]对贵州息烽野生白虫茶进行生物安全性毒理学评价,为贵州白虫茶的开发提供切实可行的科学依据。[方法]小鼠急性毒性试验,Ames微生物试验,小鼠骨髓嗜多染红细胞微核试验,Pb、Cr、Cd等采用原子吸收光谱法测定。[结果]小鼠经口LD50〉5.0g/kg（BW）,属实际无毒范围,Ames微生物试验及小鼠骨髓嗜多染红细胞微核试验均为阴性,常见污染物Pb、Cr、Cd、Hg、As和F-含量分别为2.10、0.45、0.54、0.08、1.08和19.20mg/kg,均低于国家茶叶卫生标准（GB2762-2005,NY659-2003）。[结论]贵州息烽产白虫茶对人体无毒害作用。