An experiment of selection for ovulation rate was carried out. Animals were derived from a synthetic line first selected 12 generations for litter size, then 10 generations for uterine capacity. Selection was relaxed for 6 generations. Selection was based on the phenotypic value of ovulation rate with a selection pressure on does of 30%. Males were selected from litters of does with the highest ovulation rate. Males were selected within sire families in order to reduce inbreeding. Ovulation rate was measured in the second gestation by a laparoscopy, 12 days after mating. Each generation had about 80 females and 20 males. Results of three generations of selection were analyzed using Bayesian methods. Marginal posterior distributions of all unknowns were estimated by Gibbs sampling. Heritabilities of ovulation rate (OR), number of implanted embryos (IE), litter size (LS), embryo survival (ES), fetal survival (FS), and prenatal survival (PS) were 0.44, 0.32, 0.11, 0.26, 0.35, and 0.14, respectively. Genetic correlation between OR and LS was 0.56, indicating that selection for ovulation rate can augment litter size. Response to selection for OR was 1.80 ova. Correlated responses in IE and LS were 1.44 and 0.49, respectively. Selection for ovulation rate may be an alternative to improve litter size. 相似文献
The National Scrapie Plan (NSP) for Great Britain includes selective breeding programmes. These aim to reduce the frequencies of the ovine prion protein (PrP) genotypes at high risk of developing clinical disease (principally those containing the VRQ allele) within the national flock, and select for the low-risk ARR-containing genotypes. The aim of this work was to use available data from embryo transfer programmes in guaranteed scrapie-free environments to investigate whether there was a difference in lamb birth weight associated with the lamb's PrP genotype, which might affect survival. The first analysis utilised data from 355 Cheviot lambs born between 2001 and 2004. The analysis was then repeated using a larger data set of 737 Cheviot, Dorset and Suffolk lambs born between 1999 and 2003. The most important determinants of mean lamb birth weight were litter size, sex and recipient ewe breed, plus lamb breed in the three breed analysis. In both analyses the effects of all these variables are consistent and of the same order of magnitude. In the first analysis there was evidence for an apparent increase in mean lamb birth weight for the ARR-containing genotypes of 0.3 kg (95% C.I. 0.1–0.5 kg). Whereas, in the second data set there was evidence for a decrease in mean lamb birth weight for the VRQ-containing genotypes of − 0.6 kg (95% C.I. − 0.8 to − 0.4 kg). This had been masked in the first analysis by the categorisation of these genotypes with the ARQ/ARQ genotype. Within these flocks, in a scrapie-free environment, neither finding provides support for concerns that selection for low risk ARR-containing genotypes would be detrimental to lamb birth weight, which is considered to be the most important determinant of lamb survival. Extension of this work into field flocks, where scrapie-status cannot be easily assured, will require the collection of sufficient data to adjust for known direct effects as well as any additional potential confounding effects. 相似文献
The racing careers of 2, 3, 4, and 5-year-old Thoroughbreds and French trotters born in France between 1995 and 1999 were analysed. The horses were evaluated on a set of traits, with particular attention to annual or career earnings and number of starts.
As expected, the distributions of earnings corrected for year, age and sex are very skew and thus inappropriate for breeding value estimations. However, Log transformation results in near normal distributions more suitable for this purpose.
Another problem of annual or career earnings required a more complex approach. As most horses did not win any money in France (67% of the trotters and 41% of the Thoroughbreds), it is difficult to correctly evaluate these horses. On the other hand, a linear adjustment of the Log of earnings by the Log of the number of starts (exponential adjustment of the earning index) leads to regression coefficients close to 1. It justified the use of the Log of earnings per start and explained its higher heritability in literature. A quadratic adjustment of the Log of earnings by the Log of the number of starts (sigmoid adjustment of the earning index) improves the adjustment for the Thoroughbred only and should be implemented for these horses.
The probability of a horse to be placed according to the number of starts was also studied. It is shown that the observed percentage of non-placed horses ps according to the number of starts, s, is in all cases inferior to the expected percentage (ps < p1s). Therefore, races of the same horse cannot be considered as independent events. The percentage of horses placed and the mean earnings for each age can be combined in order to estimate the economical weights for each age class. Economical weights for the French trotter were 0.00, 0.21, 0.40, and 0.39 for 2, 3, 4, and 5-year olds respectively. They were 0.11, 0.45, 0.26 and 0.18 respectively for Thoroughbreds of the same age categories. The current tendency to move from annual or career criteria towards criteria at the race level is discussed. However, the question on how to evaluate the important proportion of horses born that never appeared in a race still remains open and should focus future research. 相似文献
Landscape geneticists can take considerable advantage of differences in the action of evolutionary forces (mutation, migration,
selection, and drift) on different loci within the genome. Appropriate comparisons among loci allow researchers to isolate
and study the effects of these processes. For example, the organelles are typically inherited maternally (but occasionally
paternally), and so will experience migration only when females or seeds disperse (males or pollen in the paternally inherited
organelles). Thus, the comparison with biparentally inherited loci allows inferences about the differential migration rates
of male vs. female animals or of seeds vs. pollen in plants. Conversely, all biparentally inherited nuclear loci should experience
the same levels of migration and drift. Thus, loci that show unusually large levels of variation across the landscape (as
compared with the bulk of loci) may be reflecting the action of spatially varying natural selection (local adaptation). Such
comparisons are conceptually straightforward, but are complicated by the high intrinsic variability of stochastic neutral
processes. Careful statistical analysis is needed to avoid over-interpreting differences among loci. Inferences will be most
robust when both genetic and non-genetic data can be integrated, and the collaboration of landscape ecologists with geneticists
promises to be particularly fruitful. 相似文献