红枣山药蓝莓咀嚼片的研发及其免疫增强功能评价

以红枣、山药、蓝莓果粉为主要原料,辅以微晶纤维素、木糖醇和柠檬酸制备咀嚼片。通过单因素试验和响应面分析对产品配方进行优化,结果表明,红枣山药蓝莓咀嚼片的最佳配方为:红枣粉与山药粉添加质量比为2.5∶1(总量为10 g),蓝莓果粉添加量为10 g,微晶纤维素添加量为3.8 g,木糖醇添加量为0.3 g,柠檬酸添加量为0.09 g及0.5%硬脂酸镁,按该配方制得的咀嚼片外观光整,组织坚实、不松散、剖面紧密、不粘连,酸甜适中,无异味,无粗糙感,硬度适中,宜咀嚼。通过动物体内试验证实,产品可以有效延缓小鼠免疫器官的自然萎缩,提高小鼠体液免疫和细胞免疫,增强小鼠NK细胞活性,能够在一定程度上改善机体免疫功能。     

复方鳖甲软肝片辅助治疗慢性丙型肝炎纤维化疗效观察

目的 观察复方鳖甲软肝片辅助治疗慢性丙型肝炎纤维化的疗效。方法 将56例慢性丙肝患者随机分为观察组与对照组各28例,观察组采用复方鳖甲软肝片联合聚乙二醇干扰素ɑ-2b（PegIFNɑ-2b）及利巴韦林治疗,对照组采用PegIFNɑ-2b及利巴韦林进行治疗,疗程24周,持续2个疗程。观察比较2组患者的病毒学应答、肝脏瞬时弹性成像,检查测定肝脏硬度值（LSM）、治疗前后血清丙氨酸氨基转氨酶（ALT）及透明质酸（HA）、层粘连蛋白（LN）、Ⅲ型前胶原（PC-Ⅲ）、Ⅳ型胶原（Ⅳ-C）、血清肿瘤坏死因子α（TNF-α）、转化生长因子-β1（TGF-β1）、白介素6（IL-6）的变化。结果 观察组患者获得持续病毒应答（SVR）20例,对照组18例,组间比较差异无统计学意义（P> 0.05）;两组LSM较治疗前均降低,观察组LSM显著低于对照组（P< 0.05）;治疗后观察组ALT、HA、LN、PC-III、IV-C、TNF-α、TGF-β1、IL-6较治疗前显著降低,差异有统计学意义（P< 0.05）,观察组治疗效果优于对照组,差异有统计学意义（P< 0.05）。结论 复方鳖甲软肝片可显著改善慢性丙型肝炎肝纤维化程度,起到辅助治疗的作用。     

银杏叶提取物分散片的处方优化

目的利用正交设计优选银杏叶分散片的最佳处方,制备快速起效、服用方便的银杏叶分散片。方法以崩解时间为指标,通过调节填充剂、崩解剂、润滑剂的用量,采用正交试验设计筛选最佳处方,以粉末直接压片法制备银杏叶提取物得分散片。结果最优处方为A2B2C2,即35%微晶纤维素、35%低取代羟丙基纤维素、1.0%聚乙二醇-6000。此处方制备银杏叶分散片工艺简单、硬度适中,其崩解时间、分散均匀度符合中国药典2005年版二部要求。结论优化所得处方合理,制得的银杏叶分散片具有明显的速释特征。     

绿色木霉·烯酰吗啉水分散片剂防治棉花黄萎病的研究

探讨了绿色木霉菌对棉花黄萎病菌的拮抗作用及其作用机制,结果表明:绿色木霉·烯酰吗啉水分散片剂对棉花黄萎病有良好的防治效果,处理剂量300～600倍液,对棉花黄萎病的防效达88%～97%,对供试作物安全.     

复方蜂胶制剂对糖尿病小鼠糖耐量和肝糖原的影响研究

本文通过对一种蜂胶中药复方制剂，在小白鼠糖尿病模型，以高（3．60g／kg），中（2．00g／kg），低（0．80g/kg）三个剂量组灌胃的试验观察，探讨了复方蜂胶制剂对小鼠糖耐量和肝糖原的影响。结果显示：该蜂胶复方制剂可显著改善高血糖小鼠的糖耐量和增加高血糖小鼠的肝糖原含量，且比阳性对照优降糖组起效快，维持时间也较长。     

保圣寺藏清乾隆严氏祭田“执帖”碑

苏州甪直保圣寺藏有一方清代乾隆时期严氏祭田执帖碑,碑文主要涉及的是苏州甪直严氏祭田的由来,以及政府对义田的优免措施和破坏义田行为的量刑规定。这方碑刻是重要的地方社会史资料,对于研究清代苏州地方历史具有较高的学术价值,同时对研究清代禁碑的铭文制度也有重要意义。     

Thermal behaviour and biological activity against Aedes aegypti (Diptera: Culicidae) of permethrin and pyriproxyfen in a smoke‐generating formulation

BACKGROUND: The most common ways to control dengue vector Aedes aegypti (L.) are larval source reduction in domestic habitats and ground application of small quantities of aerosol insecticide (ultralow volume). Nevertheless, these actions have been shown repeatedly to be ineffective in controlling Ae. aegypti populations. RESULTS: The efficacy of a new smoke‐generating formulation containing pyriproxyfen and permethrin was evaluated in the laboratory. Smoke‐generating tablets containing each insecticide individually or combined were prepared, and the recovery of the insecticides from the smoke was determined. Recovery values of over 90% were obtained for pyriproxyfen, and around 50% for permethrin. The biological efficacy of pyriproxyfen released in the smoke was evaluated in the laboratory, on late third‐instar or early fourth‐instar Ae. aegypti larvae, using different concentrations of pyriproxyfen and exposure times. Adult emergence inhibition (EI) values of 100% were obtained at 30 min, and a dose‐dependent effect was observed at 5 min. The effect of pyriproxyfen released in the smoke was due to direct contact with the larvicide in the water rather than by inhalation of the fumes. The efficacy of permethrin released in the fumes was also evaluated as knockdown effect (KT₅₀) on adults for a tablet containing permethrin alone or permethrin plus pyriproxyfen. There was no significant difference in KT₅₀ values obtained for permethrin (KT₅₀ = 19.9 min) and permethrin plus pyriproxyfen (KT₅₀ = 19.4 min). CONCLUSION: The excellent laboratory performance of this new formulation on immature stages and adults indicates that a smoke‐generating tablet containing pyriproxyfen and permethrin could be a new tool for controlling mosquitoes. Copyright © 2009 Society of Chemical Industry     

星点设计–效应面法优化32.5%苯醚甲环唑•嘧菌酯泡腾片剂配方

应用星点设计–效应面法对32.5%苯醚甲环唑•嘧菌酯泡腾片剂配方进行优化,以分散剂、崩解剂和起泡剂用量为考察因素,以片剂悬浮率和崩解时间为考察指标,采用多元非线性回归拟合选择合适模型,依据模型在各因素设定范围内获得最佳配方为：分散剂WG5质量分数为4.75%,分散剂TXC质量分数为1.50%,崩解剂聚乙烯吡咯烷酮PVPP质量分数为5.00%,起泡剂酒石酸和碳酸氢钠质量分数均为20%,该条件下进行3次重复试验,结果表明,片剂实际平均悬浮率为86.42%,平均崩解时间为159 s,与预测值86.14%和160 s无显著差异。     

Colquhounia root tablet inhibits the expression of adhesion molecule in acute lung injury of rats

AIM: To study the effects of colquhounia root tablet on the expression of adhesion molecule in acute lung injury of rats.METHODS: The rats were divided into 3 groups: ALI group,colquhounia root tablet＋ALI group and control group .ALI animal model was performed by treatment with oleic acid.The positive expression rates of CD11a,CD11b and CD18 in polymorphonuclear neutrophils and monocytes were analyzed by flow cytometry.ICAM-1 expression in lung tissue was determined by immunohistochemistry,histopathological examination and biological markers were measured from lung specimens.RESULTS: Colquhounia root tablet decreased the expression of CD11a,CD11b and CD18 in polymorphonuclear neutrophils and monocytes,and ICAM-1 in lung tissue (P<0.01),pathologic changes and the biological markers of ALI significantly ameliorated.CONCLUSION: The increase in the expression of CD11a/CD18 and CD11b/CD18 in polymorphonuclear neutrophils and monocytes,and expression of ICAM-1 in lung tissues of ALI may be involved in the formation of ALI.Colquhounia root tablet effectively ameliorates the lung damage,mechanism of which may be related to inhibition of adhesion molecule expression.     

金荞麦叶发酵茶咀嚼片制备工艺研究

为了寻求金荞麦叶发酵茶咀嚼片最佳配方,以金荞麦叶发酵茶为原料,添加一定的辅料制备金荞麦叶发酵茶咀嚼片。考察甜荞粉、微晶纤维素、甘露醇、柠檬酸作为咀嚼片辅料对咀嚼片综合品质的影响,并通过L9(34)正交试验对咀嚼片配方进行优化。确定咀嚼片最佳配方为:金荞麦叶发酵茶茶粉添加量为26.1%(W/W),甜荞粉添加量为17.4%(W/W),微晶纤维素添加量为20.0%(W/W),甘露醇添加量为35.0%(W/W),柠檬酸添加量为1.0%(W/W),硬脂酸镁添加量为0.5%(W/W)。