缓释复方免疫增强剂有效药物释放量及安全性试验

将100只14日龄健康肉杂仔鸡随机分成A、B、C、D、E 5个试验组,每组20只鸡,A、B、C、D 4组为试验组,E组为对照组。A、B、C 3组试验鸡每只分别投服批号为0308、0312、0402的缓释复方免疫增强剂1粒,进行有效药物释放量测定试验,试验结果表明,药物投服后日均磨损量20d前为6.2~6.7 mg,30 d前为6.0~6.3 mg,日均药物有效释放量为2.40~2.52 mg,经方差分析,批间差异不显著(P0.05),均在有效剂量之间,药物的有效释放期均在30 d以上。D组试验鸡每只投服缓释复方免疫增强剂3粒,进行有效药物安全性试验,试验结果表明,仔鸡投服后食、饮欲正常,精神状态良好,与对照组鸡相比未发现任何不良反应,从而说明该缓释制剂在鸡体内是安全有效的。     

Effect of Temperature on the Induction of Bud Dormancy in Ecotypes of Betula pubescens and Betula pendula

The purpose of this study was to determine the influence of temperature applied during short day-induced budset on induction of dormancy in six ecotypes of Betula pubescens Ehrh. and two ecotypes of Betula pendula Roth. Seedlings were grown in a phytotron at constant temperatures of 9–21°C under a 12 h photoperiod (SD) during dormancy induction. Induction of dormancy was monitored by following bud flushing and shoot growth after transfer to long photoperiod conditions (24 h) at 18°C. Chilling requirement was studied in seedlings exposed to 10 weeks of SD. In both species induction of bud dormancy developed most rapidly at 15–18°C, and both 9–12°C and 21°C delayed the induction of dormancy. Raising the temperature (from 9 to 21°C) applied during induction of dormancy significantly increased the chilling requirement. These responses were noted for all ecotypes tested, but in general the northern ecotypes entered dormancy more quickly than the southern ones. No such trend was recorded for chilling requirement, although a B. pubescens ecotype from Iceland and another from the coast of northern Norway appeared to require a longer chilling treatment than the other ecotypes. In conclusion, induction and depth of bud dormancy in birch are significantly affected by temperature conditions and these effects may explain some of the annual variation in dormancy and chilling requirement observed in nature.     

土壤湿度对东亚小花蝽越冬存活率的影响

１９９１～１９９３年在北京对东亚小花蝽的越冬进行了研究。结果表明：东亚小花蝽以交配或未交配的雌成虫越冬。越冬场所的土壤湿度影响小花蝽的存活率。３月中旬检查，室外自然条件下，越冬存活率为７．７４％。在控制土壤含水量（４％、１２％和２０％）的条件下，越冬存活率随土壤水分的增加而递增，水分２０％时存活率最高，平均为８１．１１％。３月中旬气温回升后将越冬小花蝽雌成虫移入７℃的冰箱，贮存至５月上旬，存活率为５５％，而自然条件下小花蝽已全部死亡     

Organoclays for controlled release of the herbicide fenuron

Organoclays were assayed as matrices in which to associate herbicides, with the aim of decreasing product losses that could give rise to water contamination from agricultural activities. Fenuron was selected as model of a very mobile and highly water-soluble herbicide. Two different organoclays of high (A-HDT) and low (H-C18) reversible fenuron sorption were selected. Herbicide-organoclay complexes were prepared from the two organoclays and with two different fenuron contents (20 and 40 g AI kg-1) and two different mixing times, so as to form a series of weak and strong complexes. The release of fenuron from those complexes into water and water/soil suspensions gave values of T50 (time to release 50% of the fenuron content) ranging from 0.3 min to 2400 h. The total fenuron released in these closed systems ranged from 48 to 80% of the fenuron in the complex. The organoclay type (high or low sorptivity) had the greatest influence on fenuron release, followed by the strong or weak complex, suggesting that herbicide-organoclay interactions are the main factors controlling release. Soil column leaching experiments showed fenuron-organoclay complexes to be effective in reducing the peak herbicide concentration in the leachate to a half (6 microns) or a quarter (3 microns) of that obtained from the free technical compound (12 microns). Herbicide lost through leaching was reduced from 78% for the free technical fenuron to 50-30%, depending on the organoclay used as carrier and the strength of the complex. Bioassay with ryegrass showed that the weak fenuron/H-C18 complex (40 g AI kg-1) gave the same herbicidal activity as technical fenuron. The potential suitability of low-sorptive organoclays for conferring slow-release properties on the fenuron complex has been demonstrated.     

营养针剂微量元素在羊血液中释放规律研究

根据对北京地区肉羊用饲草来源及种类进行的微量元素概略调查分析,合成了肉羊用营养针剂,并对营养针剂中微量元素释放规律进行了研究。结果表明:试验组营养针剂中微量元素释放速度显著低于对照组(P<0.05),缓释剂在控制营养针剂中微量元素释放速度上有一定的效果。     

Effects of pheromone loading, dispenser age, and trap height on pheromone trap catches of the oriental fruit moth in apple orchards

The effects of field aging (0–28 days) and pheromone loading rate on the longevity of red rubber septa loaded with the sex pheromone blend of the oriental fruit mothGrapholita molesta (Busck), were evaluated in North Carolina apple orchards in 2002. Separate field tests examined the influence of trap height and pheromone loading rate of rubber septa on trap catches of adultG. molesta males in an abandoned orchard. The loss of the major pheromone component, (Z)-8-dodecenyl acetate (Z8–12:OAc), from red rubber septa over a 4-week period exhibited a relatively constant release rate with 30, 100 and 300 μg pheromone. Trap catch was significantly higher in pheromone traps placed in the upper canopy than in those in the lower canopy. Pheromone traps baited with 100μg lures caught more moths compared with those loaded with 300 μg. There was no apparent relationship between pheromone trap catch and septa age, with trap catch appearing to be primarily a function ofG. molesta population density. http://www.phytoparasitica.org posting May 14, 2006.     

Effect of road density on abundance of white-footed mice

While several studies have demonstrated that roads can act as barriers to small mammal movement, the relationship between road density and small mammal abundance has not yet been investigated. In southeastern Ontario, Peromyscus leucopus (white-footed mice) suffer high over-winter mortality rates, resulting in small springtime populations and frequent local extinctions. Peromyscus leucopus movement is known to be inhibited by roads, which should result in lower rates of immigration into and recolonization of habitats in landscapes with high road density. We tested two predictions: (1) Forest sites situated in landscapes with high road densities have a higher chance of P. leucopus being absent during the early spring than forest sites situated in landscapes with low road densities and (2) P. leucopus populations during the summer are smaller in forest sites situated in landscapes with high road densities than in landscapes with low road densities. We sampled P. leucopus in focal patches within nineteen landscapes (7 rural, low-road-density landscapes; 7 rural, high-road-density landscapes; 5 urban landscapes). There was no significant relationship between road density and the presence/absence of P. leucopus during the early spring. We found a significant positive effect of road density on P. leucopus relative abundance during the summer, even when we excluded the urban landscapes and based the analysis on only the 14 rural landscapes. Our results suggest that any negative effect of roads on P. leucopus populations, created by their inhibition to moving across roads, is far outweighed by some positive effect of roads on P. leucopus abundance. We suggest that the two most likely explanations are that roads are positively correlated with an important as-yet-undetermined component of habitat quality, or that roads positively affect P. leucopus by negatively affecting their predators.     

Inhibition of histamine release from dispersed canine skin mast cells by cyclosporin A, rolipram and salbutamol, but not by dexamethasone or sodium cromoglycate

Despite the important role that canine skin mast cells play in IgE-mediated allergic inflammation, clinically useful compounds for modulating mediator release from these cells or for suppressing cell response are lacking in the dog. The ability of five compounds to inhibit histamine release induced by non immunological (calcium ionophore A23187 and substance P) and IgE-dependent (concanavalin A) stimuli were compared. Sodium cromoglycate, a mast cell stabilizer, and dexamethasone, a glucocorticoid, failed to inhibit histamine release from isolated skin mast cells following any kind of stimulation. Salbutamol, a β-adrenergic agonist, exhibited inhibitory activity (46.0%) only after concanavalin A activation. In contrast, rolipram, a selective phosphodiesterase IV inhibitor and cyclosporin A, an immunosuppressor, showed potent anti allergic actions, inhibiting both IgE-dependent and -independent stimuli. Rolipram inhibited 42.8%, 44.7% and 19.2% of the mediator release induced by ionophore A23187, substance P and concanavalin A, respectively. Similarly cyclosporin A induced 85.9%, 14.9% and 67.3% inhibition after ionophore A23187, substance P and concanavalin A stimulation, respectively. These results suggest that rolipram and cyclosporin A merit to be clinically tested as agents for the treatment of chronic allergic diseases in the dog.     

硝化抑制剂缓释尿素试验效果初探

硝化抑制剂缓释尿素具有提高氮素利用率、增产、增收、节肥等功效。为验证其在水稻上的应用效果,特进行此试验。结果表明:底肥一次性施用硝化抑制剂缓释尿素或第一代缓释尿素对水稻具有不同程度的增产效果,分别增产6.7%、3.9%,净增收76.35元/667 m2、52.19元/667 m2,节省肥料、节省功时费,在生产上有一定推广价值。     

Influence of terminal rig configuration on the anatomical hooking location of line-caught yellowfin bream, Acanthopagrus australis

Abstract  Experiments were carried out to test the dependence of anatomical hooking location on terminal rig configuration, and identify strategies by which hook ingestion can be minimised to reduce post-release mortality of angled yellowfin bream, Acanthopagrus australis (Günther). Eighty-five anglers targeted yellowfin bream using different designs and sizes of circle and J hooks and recorded technical, environmental and biological data for each landed fish. Considerably fewer fish (16.6 and 8.5%, respectively) ingested hooks than those hooked in the mouth (82.1 and 88.6%), and a greater percentage of J hooks were ingested than circle hooks or a J hook modified with a 15-mm horizontal bar. Irrespective of hook type, the rate of ingestion also declined with increasing hook weight and decreasing fish size. In cage experiments, significantly more hooks baited with natural soft baits (e.g. intestines and cephalopods) were ingested than those baited with artificial baits, crustaceans or teleosts, while in the field fewer hooks were ingested using artificial bait (e.g. bread and pellets) than terrestrial animals, teleosts, crustaceans, teleost or terrestrial animal intestines, cephalopods or polychaetes. Similarly, rigs with floats, short traces or a sinker only on the hook, along with angling in environments with at least some current reduced ingestion. Based on this study, anglers targeting yellowfin bream should be encouraged to use circle or modified J hooks and, regardless of the hook design, the largest hook size possible attached to short traces or a sinker only and hard baits.