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61.
Researches have shown that cancer stem cells,regulated by the niche where they reside,are the roots of oncogenesis,relapse and metastasis.To date,very few treatments have targeted on cancer stem cells.... 相似文献
62.
非英语专业大学生英语口语中的语言僵化是一个普遍现象。本文通过教学实践和调查具体分析了大学生口语僵化的原因,从而制定出了口语激活策略,从教学理念、教学方法和考试模式三个方面进行改革。通过一年的教学实践,学生在口语表达时的流利程度、语法词汇的正确使用和交际能力方面都有了显著的提高,而且综合英语能力也有很大提高。实验结果证明,非英语专业大学生的口语僵化是可以被激活的。 相似文献
63.
R. J. Corbee H. E. Booij‐Vrieling C. H. A. van de Lest L. C. Penning M. A. Tryfonidou F. M. Riemers H. A. W. Hazewinkel 《Journal of animal physiology and animal nutrition》2012,96(4):671-680
Feline chronic gingivitis/stomatitis (FCGS) is a painful inflammatory disease in cats. Extraction of teeth, including all premolars and molars, has been shown to be the therapy of choice in cats not responding sufficiently to home care (e.g. tooth brushing) and/or medical treatment (corticosteroids and/or antibiotics). In this study, we hypothesize that a cat food with an omega‐6 polyunsaturated fatty acid (ω6 PUFA) to ω3 PUFA ratio of 10:1 reduces inflammation of the FCGS and accelerates soft tissue wound healing of the gingiva after dental extractions, compared to a cat food with a ω6:ω3 PUFA ratio of 40:1. The cats were fed diets with chicken fat and fish oil as sources of fatty acids. In one diet, part of the fish oil was replaced by safflower oil, resulting in two diets with ω6:ω3 PUFA ratios of 10:1 and 40:1. This double‐blinded study in two groups of seven cats revealed that dietary fatty acids influence the composition of plasma cholesteryl esters and plasma levels of inflammatory cytokines. The diet with the 10:1 ratio lowered PGD2, PGE2 and LTB4 plasma levels significantly, compared to the diet with the 40:1 ratio (p = 0.05, p = 0.04, and p = 0.02 respectively). However, feeding diets with dietary ω6:ω3 PUFA ratios of 10:1 and 40:1, given to cats with FCGS for 4 weeks after extraction of all premolars and molars, did not alter the degree of inflammation or wound healing. 相似文献
64.
AIM: To investigate the expression of TNF-α, TGF-β in patients with oral lichen planus (OLP) and normal oral mucosa (NOM). METHODS: An immunohistochemical technique was performed to detect TNF-α, TGF-β1 and TGF-β2 expression in 22 cases with OLP and 10 normal controls. RESULTS: In lamina propria of OLP, the expression of TNF-α and TGF-β1 were increased, whereas TGF-β2 did changed significantly compared with control group. TNF-α positive signal were mostly found in macrophages, lymphocytes. TGF-β1 positive cell was present in macrophages, endothelial cells and fibrocytes. CONCLUSION: TNF-α and TGF-β1 play an important role in the development and maintenance of OLP local inflammation. 相似文献
65.
Sabnis S 《Veterinary research communications》1999,23(7):425-447
The oral route is presently the preferred route of drug delivery. Poor oral bioavailability results in variable concentrations of drugs in the plasma and variable pharmacological responses, in addition to higher product costs. The unique canine physiology, anatomy and biochemistry makes designing canine dosage forms a challenging exercise. This article reviews the physicochemical, physiological, pharmacokinetic, pharmacological and formulation factors that can influence the drug availability of the oral formulations in dogs in an effort to provide a source of data to aid development of canine drug products with superior bioavailability. 相似文献
66.
Telomere shortening in normal somatic cells has been proposed as a major barrier to unlimited cellular proliferation. Telomerase is an enzyme capable of maintaining telomere length, and thus bypassing this barrier. In human beings, telomerase activity is restricted to cancer cells and cells of stem or germ cell lineages. Dogs represent a potentially useful clinical model for the development of telomerase‐based therapies because telomerase activity is also restricted to cancer cells and stem cells in this species. We examined the ability of telomestatin to inhibit telomerase activity in telomerase‐positive D17 and CMT7 canine cancer cell lines. At a concentration of 2 μM, telomestatin treatment resulted in a decrease in telomerase activity, telomere shortening, growth inhibition and apoptosis in telomerase‐positive cancer cells. These effects were not seen in telomerase‐negative skin fibroblasts or negative controls. These results confirm that telomestatin specifically inhibits telomerase activity in canine cancer cells and strengthens the usefulness of dogs as a model for testing telomerase‐based therapies. 相似文献
67.
Current and prior veterinary cancer registries are few in number and scattered. Different inclusion criteria, dissimilar collection methods and variable reference population estimation methods pose obstacles in the comparisons between veterinary and human cancer registries. Veterinary cancer registries have yielded information on the risk and incidence of different cancer types in certain breeds and geographical regions, as well as provided information on genetic and environmental risk factors in some cancers. The objective of this article is to review the prior and current veterinary cancer registries, the information they have contributed and to discuss different issues relating to their structure including inclusion criteria, study populations, reference populations utilized in evaluations, recorded variables and the outcome from these. 相似文献
68.
Sung Jae Shin Seung Won Shin Mi Lan Kang Deog Yong Lee Moon-Sik Yang Yong-Suk Jang Han Sang Yoo 《Journal of veterinary science (Suw?n-si, Korea)》2007,8(4):383-392
We previously induced protective immune response by oral immunization with yeast expressing the ApxIIA antigen. The ApxI antigen is also an important factor in the protection against Actinobacillus pleuropneumoniae serotype 5 infection; therefore, the protective immunity in mice following oral immunization with Saccharomyces cerevisiae expressing either ApxIA (group C) or ApxIIA (group D) alone or both (group E) was compared with that in two control groups (group A and B). The immunogenicity of the rApxIA antigen derived from the yeast was confirmed by a high survival rate and an ApxIA-specific IgG antibody response (p < 0.01). The highest systemic (IgG) and local (IgA) humoral immune responses to ApxIA and ApxIIA were detected in group E after the third immunization (p < 0.05). The levels of IL-1β and IL-6 after challenge with an A. pleuropneumoniae field isolate did not change significantly in the vaccinated groups. The level of TNF-α increased in a time-dependent manner in group E but was not significantly different after the challenge. After the challenge, the mice in group E had a significantly lower infectious burden and a higher level of protection than the mice in the other groups (p < 0.05). The survival rate in each group was closely correlated to the immune response and histopathological observations in the lung following the challenge. These results suggested that immunity to the ApxIA antigen is required for optimal protection. 相似文献
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