Diagnostic and prognostic utility of surface electrocardiography in cats with left ventricular hypertrophy

Objectives

To assess the ability of electrocardiography (ECG) to predict left ventricular hypertrophy (LVH) in the cat and to investigate the prognostic value of selected ECG variables in cats with LVH.

基于智能算法的猪饲料配方优化数学模型

在多种原料配比过程中,营养指标因素复杂的实际情况及控制成本保证收益的现实需求,文章结合智能算法背景,进行猪饲料配方优化设计,建立猪饲料配方模型,采用智能算法求解饲料配方的过程,对于生猪饲料配方进行建模,同时优化出饲料配方.结果表明,智能算法的猪饲料配方优化能够解决多种原料配比以及多个营养指标复杂因素,实现快速计算和生产...     

ROUTE DEVELOPMENT,ANTIVIRAL STUDIES,FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT NK0238

• Developed a two-step synthetic route to anti-plant-virus candidate NK0238. • NK0238 exhibited a broad antivirus spectrum in greenhouse. • NK0238 showed comparable antivirus activities as controls in field trials. • NK0238 was safe to birds, fish, bees and silkworms. • NK0238 has a very good prospect in commercial development. It has previously been shown that tryptophan, the biosynthesis precursor of Peganum harmala alkaloids, and its derivatives have anti-TMV activity both in vitro and in vivo. Further exploration of this led to the identification of NK0238 as a highly effective agent for the prevention and control of diseases caused by plant viruses, but the existing routes are unsuitable for its large-scale synthesis. This study optimized a route for two-step synthesis of this virucide candidate via reaction of l-tryptophan with triphosgene to produce l-tryptophan-N-carboxylic anhydride, which then reacts with n-octylamine to give NK0238 at up to 94% yield and nearly 97% HPLC purity. In addition, the route was used for the preparation of NK0238 on a>40 g scale permitting further assessment of its antivirus activity in the greenhouse and field experiments, and toxicity tests. NK0238 exhibited useful antiviral activities against a variety of viruses both in greenhouse and field experiments. The toxicity tests showed that NK0238 was not acutely toxic to birds, fish, honey bees and silkworms. The optimized route provides a solid foundation for its large-scale synthesis and subsequent efficacy and toxicity studies, its excellent activity and safety make NK0238 a promising drug candidate for further development.     

秸秆膨化机度电产量的生产参数优化及影响因素分析

本文对影响秸秆膨化机度电产量的主要生产参数—秸秆含水率(X1)、秸秆粒度(X2)和螺杆转速(X3)进行了研究,揭示了度电产量与这些参数之间的内在规律,创建了秸秆度电产量与三个参数之间的数学模型,进行了生产参数优化,并就生产参数对度电产量的影响进行了分析。     

The Optimal Model of Repaying Debt for Construction Projects and Its Applications

In this paper the optimal model of repaying debt combined with operational research and technology economics was presented. It is for solving the problem to increase the benefit of project in terms of planning to repay capital with interest.     

Evaluation of reticulocyte hemoglobin content (RET‐He) in the diagnosis of iron‐deficient erythropoiesis in dogs

Background

Reticulocyte hemoglobin content provided by the Siemens ADVIA (CHr) is an established marker of iron deficiency. The IDEXX ProCyte Dx hematology analyzer now provides a similar variable, reticulocyte hemoglobin equivalent (RET‐He).

Objectives

The objective was to evaluate RET‐He and its diagnostic utility in dogs, and to calculate a cutoff value for diagnosing iron‐deficient erythropoiesis (IDE). Furthermore, the prevalence of RET‐He values below this cutoff value was established.

Methods

One hundred and seventy‐one CBCs of healthy dogs were used to establish a RI. Stability of RET‐He was evaluated by repeated measurements over 48 hours (n = 10). The 25‐run coefficient of variation (CV) was calculated, and correlation and bias between measurements of RET‐He and CHr were assessed (n = 190). A cutoff value for diagnosing IDE was calculated. The utility of RET‐He in the detection of IDE was evaluated in 123 dogs. The prevalence of low RET‐He values was assessed retrospectively in a multicenter study (2012–2014) under participation of 7 veterinary clinics.

Results

Reticulocyte hemoglobin equivalent with an RI of 22.2 to 28.6 pg was statistically stable over 48 hours (P = .10). The CV was 1.8%. A fair correlation (ρ = 0.74) between RET‐He and CHr with a small bias of ?0.6 pg was found. The cutoff value for diagnosing IDE was 20.9 pg (sensitivity: 85%; specificity: 99%). The prevalence of RET‐He values below 20.9 pg was 10.3% (1084/10,553 dogs).

Conclusions

RET‐He on the ProCyte Dx is a precise screening tool in dogs to detect iron‐deficient erythropoiesis.     

遗传算法在离心泵叶片优化设计中的应用

对遗传算法在流体机械优化设计中的应用现状作了较为全面的总结；提出了将遗传算法应用于离心泵叶片优化设计中，分析了遗传算法在离心泵优化设计中应用的可行性以及存在的问题；对离心泵优化设计的发展提出了一些新建议和尝试。     

太平洋牡蛎(Crassostrea gigas)类α-1,2-岩藻糖基转移酶的密码子优化与原核表达

牡蛎消化组织内存在的类A型血型组织抗原是其特异性富集诺如病毒的主要原因,FUT2(Fucosyltransferase 2,α-1,2-岩藻糖基转移酶)是A型血型组织抗原合成的关键酶.本研究在前期克隆了太平洋牡蛎(Crassostrea gigas)类FUT2基因cDNA全长的基础上,根据大肠杆菌密码子偏爱性优化并合成了类FUT2基因,插入原核表达载体pRSET A构建pRSET-mof,将其转化大肠杆菌BL21,用异丙基-β-D-硫代半乳糖苷(IPTG)诱导.经SDS-PAGE分析显示,在37℃、IPTG终浓度为0.8 mmol/L的条件下,诱导4h后出现大小约为46 kDa的特异性目的条带.利用His亲和层析柱纯化及超滤管浓缩目的蛋白,得到单一条带,说明纯化效果良好.Western blot分析显示,目的蛋白与抗6×His标签单克隆抗体、抗人FUT2单克隆抗体均能发生特异性反应,表明优化后的太平洋牡蛎类FUT2基因在大肠杆菌系统中成功表达.本研究结果为今后研究太平洋牡蛎类FUT2基因的功能,进一步探索牡蛎特异性富集诺如病毒的分子机理奠定了基础.     

A Furry Synthetic Evaluation Model in Capital Structure Decisions

This paper analyzes the limitation of regarding the weighted average cost of capital as the optimal standard of capital structure in the traditional capital structure decision-making method, and analyzes the view that the capital structure is affected by many factors,such as earning power, long-term stability of operating, the attitudes held by owners and operators, the attitudes held by creditors and financial risk. With the example, the affecting factors of the capital structure is analyzed. The fuzzy synthetic evaluation model are employed to decision-making of the capital structure. This article also shows the key point of its application.     

Study and Practice of Safety Grade Assessment for Large Convention and Exhibition Centre

This paper takes "how to estimate the complex security of Large Convention and Exhibition Centre effectively" as the research goal.Based on analyzing the difficulties,target system,technical constitution,probing into the architecture,safety science,and using for reference the mathematics,operational research,statistics and modern system theory and method,trying to explore establishing an evaluation methodological system,which is provided with integrated characters on subject.Based on these ways,it exerts "quality to quantity" fuzzy analytical hierarchy process(FAHP) and aims at discussing the safety grade assessment of the Chongqing International Conference Exhibition Center focusing on designing theories.The aim is to enhance the integration of design practice and safe consciousness,strengthen the building safety management,and perfect city public security system.In practice,it is also an efficient tool for favoring values of architectural environmental safety.