肺动脉高压与肉鸡腹水综合征发生发展的关系

２００只艾维茵商品代肉鸡常规育雏,１５日龄时随机分为两组,１００只在常规温度（２７～２３）℃下饲养,为常温组;１００只在低温（９～１１）℃环境中饲养,为低温组。利用右心导管法动态测定肺动脉压（ＰＡＰｍ）,并测定腹水心脏指数（ＡＨＩ）,统计各组腹水发生率。结果为：（１）分组后７、２１ｄ,低温组ＰＡＰｍ极显著高于常温组（Ｐ〈０．０１）;低温组腹水发生率显著高于常温组（Ｐ〈０．０５）。表明低温可引起肺动     

表皮生长因子受体在妊娠滋养细胞疾病的表达及其意义

目的：研究表皮生长因子受体(EGFR)在妊娠滋养细胞疾病的表达及其临床意义。方法：采用免疫组化方法，检测石蜡包埋的l05例妊娠滋养细胞疾病和20例正常早孕绒毛组织EGFR蛋白表达水平。结果：EGFR蛋白在妊娠滋养细胞疾病和正常早孕绒毛中均有不同程度的表达，在合体滋养层中，妊娠滋养细胞疾病和正常早孕绒毛组织均强烈表达EGFR蛋白，它们之间的表达差异无显著性。在细胞滋养层，正常早孕绒毛EGFR蛋白表达显著高于葡萄胎(P＜0．01)，葡萄胎EGFR蛋白表达显著高于侵蚀性葡萄胎和绒癌(P＜0．01)，EGFR蛋白表达在侵蚀性葡萄胎和绒癌之间差异无显著性(P＞0．05)。EGFR蛋白表达水平与滋养细胞肿瘤临床指标无关。结论：EGFR表达降低反映了在妊娠滋养细胞疾病发生发展过程中EGFR起重要作用。     

Gene expression of endothelin-1 and its receptors in the heart of broiler chickens with T(3)-induced pulmonary hypertension

To investigate the effect of T₃-induced pulmonary hypertension on endothelin (ET) production and genes expression of ET-1, ET_A and ET_B receptors (ET_AR and ET_BR) during rearing, semiquantitative RT-PCR and enzyme immunometric assay were performed in the heart ventricles and serum, respectively. The ET-1 and its receptor genes were expressed in the right and left ventricles of control and T₃-treated broilers at 12, 28 and 49 days of age. There were significant (P < 0.05) reductions of the relative amounts of ET-1 (in both ventricles) and ET_AR (in the right ventricle) mRNAs at 28 and 49 days of age, in T₃-treated broilers compared to controls. The relative amounts of ET_BR mRNA in the right and left ventricles did not significantly differ between control and T₃-treated broilers at any age. The serum level of ET was significantly (P < 0.05) increased in T₃-treated chickens at 28 and 49 days of age when compared with that of the control. It is concluded that ET-1, ET_AR and ET_BR genes are normally expressed in the heart ventricles of broilers. It is likely that increased serum level of ET and decreased ET-1/ET_AR genes expression in the ventricles are involved in the heart dysfunction of broiler chickens with developmental pulmonary hypertension.     

吲哒帕胺治疗22例高血压病的动态血压监测

目的：评价吲哒帕胺治疗高血压的疗效和安全性,方法：予２２例轻中度的Ⅱ期高血压病患者服吲哒帕胺８周,利用２４ｈ动态血压监测和常规血压观察其疗效。并监测患者血糖、血Ｋ等生化指标。结果：常规血压和动态血压显效率为９０．９％,总有效率均为１００％,２２例治疗前后动态血压监测示：吲哒帕胺能显著地降低２４ｈ,白昼和夜间的平均血压和降低夜／白昼血压均值比值,同时吲哒帕胺的降压效应谷峰比值：ＳＢＰ（０．６４±０．     

高钠所致肉鸡腹水综合征发病机理的研究

２４０只健康ＡＡ肉鸡随机均分为试验Ｉ组,试验Ⅱ组和对照组,从８日龄起饮用含Ｎａ＾＋６００,１２００和０ｍｇ／Ｌ水。在饲养管理条件相同情况下,观察各组肉鸡临床表现,血液红细胞压积（ｐａｃｋｅｄ ｃｅｌｌ ｖｏｌｕｍｅ,ＰＣＶ）,血容量（ｂｌｏｏｄ ｖｏｌｕｍｅ,ＢＶ）,红细胞变形性（ｅｒｙｔｈｏｃｙｔｅ ｄｅｆｏｒｍａｂｉｌｉｔｙ,ＥＤ）,右心室（ｆｉｇｈｔ ｖｅｎｔｒｉｃｌｅ,ＲＶ）,与全心室（ｔ