5-Lipoxygenase expression in benign and malignant canine prostate tissues

5-Lipoxygenase (5-LO) is overexpressed in human prostate carcinomas (PCs), and its inhibition decreases proliferation and induces apoptosis in prostate cancer cell lines. We hypothesized that 5-LO would be overexpressed in canine PC compared with benign prostate tissue and may be important in the pathogenesis of the disease. Immunoblot analysis of canine PC and benign prostatic hyperplasia (BPH) tissues demonstrated 5-LO expression in both. 5-LO immunohistochemical staining was not significantly different within the stromal or epithelial components of canine primary PC, BPH or suppurative prostatitis, suggesting that differential expression of this enzyme does not occur in these conditions. The percentage of tumour cells expressing 5-LO was significantly lower in metastatic PC lesions compared with primary PC (P < 0.0001). This decreased expression may indicate down-regulation or altered expression of the enzyme with progression of canine PC to a metastatic phenotype.     

90例先天性心脏病非侵入性诊断与手术结果比较

二维和多普勒超声心动图检查９０例先天性心脏病患儿，并与手术结果对照。结果与手术诊断的符合率分别为ＶＳＤ９７．８％，ＰＤＡ９６％，ＡＳＤ１００％。本组病例中８例有合并畸形，其中３例误诊。因此，超声心动图检查时应注意合并畸形的诊断。     

AGENESIS OF THE DISTAL PHALANX IN A MULE

Agenesis of the distal phalanx of a mule foal is documented. The condition was identified when the foal was 14 days old and supported by follow-up radiographs obtained at four months of age.     

Pheochromocytoma Presenting as Acute Retroperitoneal Hemorrhage in a Dog

Objective: This report describes the perioperative management of a dog with a right adrenal pheochromocytoma that presented with acute retroperitoneal hemorrhage, cardiac arrhythmia and hypertension. Additionally, a summary of pheochromocytoma and the idiosyncrasies of perioperative management of a pheochromocytoma are provided.
Summary: A 7-year old male, neutered, Dalmation was presented for acute collapse, abdominal pain and tachycardia. Physical examination findings were consistent with hypoperfusion concurrent with multiple cardiac arrhythmias and hypertension. Abdominal ultrasound revealed retroperitoneal effusion and a right adrenal mass intimately associated with the caudal vena cava. Incomplete right adrenalectomy was performed. Histopathology confirmed a pheochromocytoma.
Unique information provided: To the authors' knowledge, this is the first definitive report of acute retroperitoneal hemorrhage as the initial clinical manifestation of histologically confirmed adrenal pheochromocytoma in the dog. ( J. Vet Emerg Crit Care 2001; 11(3): 221–227 )     

MULTIPLE CONGENITAL URINARY TRACT ABNORMALITIES IN A BITCH: A CASE HISTORY REPORT

A 2 1/2-month-old, female German Shepherd Dog was examined because of incontinence since birth. Multiple urinary anomalies which included left renal agenesis, right hydronephrosis and hydroureter and urinary bladder dysfunction were found by excretory urography. These abnormalities were confirmed at necropsy. In addition, vesicovaginal continuity with apparent absence of the urethra was also found     

三种增菌液对食品沙门氏菌检验结果比较试验

本试验以三种增菌液，对３００份鲜猪肉和１２０份鲜鸡肉检样进行沙门氏菌增菌培养，比较三种增菌液的增菌检出效果。结果表明：ＭＭ液对鲜猪肉和鲜鸡肉检样中沙门氏菌捡出率最高，分别为２２．７％、５３．３％，平均捡出率３１．４％，敏感指数８８．０％；ＳＭ液次之，检出率２０．３％、４７．５％，平均检出率２８．１％，敏感指数７８．７％；ＳＢＧ液最低，检出率分别为１９．３％、４０％，平均检出率２５．２％，敏感指数７０．７％。ＭＭ液和ＳＭ液检出沙门氏菌菌株符合率均高于ＳＢＧ液，分别为８８．０％和７８．７％。     

Ultrasonographic identification of vascular invasion by adrenal tumors in dogs

Adrenalectomy is the treatment of choice for adrenal tumors that are producing adverse clinical signs. Surgical planning prior to adrenalectomy is aided by identifying tumors with invasion into adjacent vessels or the presence of a tumor thrombus extending into the caudal vena cava. In this paper, we evaluated the sensitivity and specificity of ultrasound in determining if vascular invasion or tumor thrombus is present. Thirty-four dogs with 36 adrenal tumors were reviewed retrospectively. Overall, 36% of tumors had vascular invasion. Abdominal ultrasound was 100% sensitive and 96% specific in identifying the presence of a tumor thrombus in the caudal vena cava. The sensitivity and specificity was 76% and 96%, respectively, when all forms of vascular invasion were evaluated and included patients with vascular wall invasion without concurrent thrombus. Abdominal ultrasound is a good screening tool for identifying vascular invasion or tumor thrombus associated with adrenal tumors in dogs.     

Effect of calf death loss on cloned cattle herd derived from somatic cell nuclear transfer: Clones with congenital defects would be removed by the death loss

To increase public understanding on cloned cattle derived from somatic cell nuclear transfer (SCNT), the present review describes the effect of calf death loss on an SCNT cattle herd. The incidence of death loss in SCNT cattle surviving more than 200 days reached the same level as that in conventionally bred cattle. This process could be considered as removal of SCNT cattle with congenital defects caused by calf death loss. As a result of comparative studies of SCNT cattle and conventionally bred cattle, the substantial equivalences in animal health status, milk and meat productive performance have been confirmed. Both sexes of SCNT cattle surviving to adulthood were fertile and their reproductive performance, including efficiency of progeny production, was the same as that in conventionally bred cattle. The presence of substantial equivalence between their progeny and conventionally bred cattle also existed. Despite these scientific findings, the commercial use of food products derived from SCNT cattle and their progeny has not been allowed by governments for reasons including the lack of public acceptance of these products and the low efficiency of animal SCNT. To overcome this situation, communication of the low risk of SCNT technology and research to improve SCNT efficiency are required.