Time-frequency Analysis of Heart Sound

The structural defects of the heart are often reflected in the sounds that heart produces. Because of the non-stationary of the PCG signal, it is important to maintain its time-frequency character. We discuss the Short-Time Fourier Transform (STFT) method and the wavelet method. Some normal and abnormal heart sounds were analyzed by these methods. We can see the advantage and disadvantage of them obviously from the examples.     

Nonlinear Finite Element Analysis of RC Deep Flexural Simply Supported Beams Using Disturbed Stress Field Model

A nonlinear finite element analysis of 4 RC deep flexural simply supported beams with the program VT2 is presented. Crack development and failure modes , longitudinal reinforcement strain distributions and load -deflection curves were compared as a result in order to evaluate the validity of the disturbed stress field model to analyse such deep simply supported beam.     

工况对发动机排气门失效的影响

发动机排气门在高温冲击环境下工作，恶劣的工况环境是使排气失效的重要原因之一。虽然在这种工况下，环境介质、气门机构的动力学特性都可使气门早期失效，但大量的研究表明：在正常情况下，影响气门失效的主要工况参数是温度及冲击次数。为此，讨论了汽车发动机工况对排气门失效的影响；探讨了进一步提高其使用寿命的有效途径。     

基于实验和CFD分析的QDP-200电泵故障诊断与改进

对QDP-200塑料泵进行了性能试验和温升试验分析，并借助CFD软件模拟了其内部全流场的分布情况。从试验和内部流动规律双重角度深入分析，找到了此型号泵性能不能满足用户要求的原因所在：水力部件设计简化和匹配不合理使得水泵效率低，厂家盲目的“模块化”生产给实际用户带来了巨大的安全隐患；对此给出了相应的改进建议。首次用CFD技术分析了QDP-200潜水电泵在非设计工况运行时的流动情况，从流动规律角度分析了合理选型的必要性。     

深厚覆盖层上高心墙堆石坝坝顶开裂特征及原因研究

国内多座深厚覆盖层上兴建的高心墙土石坝坝顶均出现不同程度的开裂,对坝体的长期安全稳定构成威胁,受到业内广泛关注。通过地质雷达、高密度电法等物探技术确定某高心墙堆石坝顶裂缝时空分布情况,根据变形实测资料分析了其变形破坏特征,并结合工程建设情况、结构特征、运行情况等对开裂原因进行分析。结果表明坝顶裂缝产生的根本原因是土体承受的应力超过其抗拉强度或抗剪强度后而发生的破坏,直接原因为坝顶的不均匀沉降,其中水荷载、湿化变形、蓄水速度、坝顶材料特性是坝顶不均匀沉降的关键影响因素。     

Expression of cathepsin C and tumor necrosis factor-α in human coronary artery and their relationships with coronary heart disease

AIM To explore the possible mechanism of cathepsin C （CTSC） and tumor necrosis factor-α （TNF-α） in coronary heart disease （CHD） by detecting the protein expression of CTSC and TNF-α in human coronary artery tissue. METHODS The coronary artery tissues from 52 cases of CHD and 25 cases of accidental death without any heart disease in the Forensic Judicial Expertise Center of Guizhou Medical University from October 2018 to December 2019 were collected as CHD group and control group, respectively. The coronary artery stenosis and intimal plaque formation were examined by histopathology, the protein expression of CTSC and TNF-α was determined by Western blot, and the intracellular expression of CTSC and TNF-α was analyzed by immunohistochemical staining. RESULTS The results of HE staining showed that the intima of coronary artery in control group was smooth, and no thickening or stenosis was observed. In CHD group, the intima thickened irregularly, atherosclerotic plaques formed, the intima became thinner and the lumen showed eccentric stenosis in varying degrees （P<0.05）. The results of Western blot showed that the expression of CTSC and TNF-α in CHD group was significantly higher than that in control group （P<0.05）. Immunohistochemical staining showed that both CTSC and TNF-α were expressed in the cytoplasm of foam cells, and their positive expression was significantly higher than that in control group （P<0.05）. The results of Pearson moment correlation analysis showed that there was positive correlation between the expression of CTSC and TNF-α in CHD （r²=0.743, P<0.05）. CONCLUSION The up-regulated expression of CTSC in coronary artery tissue may promote the expression of TNF-α and affect the occurrence and development of CHD.     

中药防治犬猫急性肾衰竭模型试验

为了研究中药对犬猫急性肾衰竭的防治效果,选择SD雄性大鼠,在用甘油成功复制急性肾衰竭模型的同时,进行了尿量、BUN、CREA、脏器系数的测定,结果说明本药方对于急性肾功能衰竭具有明显改善作用。     

Effects of cardiac contractility modulation on ventricular electrical remodeling in rabbits with chronic heart failure

AIM: To investigate the effects of cardiac contractility modulation (CCM) on ventricular electrical remodeling in a rabbit model of chronic heart failure. METHODS: The rabbits were divided into sham group, heart failure(HF) group and HF+ CCM group. The rabbit model of chronic heart failure was established by ligating the ascending aortic root. Then electrical stimulations during the absolute refractory period were delivered lasting 6 h everyday for 4 weeks in rabbits of HF+ CCM group. The QTc and ventricular effective refrective period (VERP) were recorded. The protein and mRNA levels of Kv1.4, Kv4.3 and connexin 43 (Cx43) were determined by Western blot and RT-qPCR. RESULTS: Compared with sham group, QTc were significantly prolonged in HF rabbits at week 12 (P<0.05). CCM therapy shortened QTc of rabbits with heart failure at week 16 (P<0.05). Compared with sham group, VERP significantly increased in HF group and HF+ CCM group, while CCM therapy shortened VERP of rabbits with heart failure at week 16 (P<0.05). Compared with sham group, the mRNA and protein levels of Kv1.4, Kv4.3 and Cx43 were decreased in HF group and HF+ CCM group (P<0.05). However, CCM therapy restored the mRNA and protein levels of Kv1.4, Kv4.3 and Cx43 of rabbits with heart failure (P<0.05). CONCLUSION: CCM suppresses ventricular electrical remodeling in heart failure and the underlying mechanism may be associated with increasing Kv1.4, Kv4.3 and Cx43 expression.     

基于热致液晶弹性体的仿生心脏泵的设计

为设计一款仿生心脏功能较佳的心室泵,采用柔性、热致伸缩的热致形变弹性体代替心肌,根据螺旋心室心肌带理论,选择心肌带的左心室段,并选取了Hilbert平面填充曲线作为热致导体在热致形变弹性体中的走行方式,设计出与真实心脏类似的心室泵结构.通过试验测量了所设计的心室泵的射血分数与心率,结果显示该心室泵的搏出量高于自然心脏,而其心率远低于自然心脏.相对于机械泵,所设计的心室泵结构与真实心脏类似,具有收缩能力强,射血分数高的优点,且不易破坏血细胞,生物相容性较好.不足之处在于,热致动液晶弹性体变形响应慢,暂时还未能达到正常心脏的心率.论证了构建双稳态结构,提高仿生心室泵效率的可能性,以及对于心肌纤维走向较为复杂的其他心肌带段,双轴拉伸机械雕刻对其仿生的可能性.此研究可为容积心脏泵的研发提供新的思路,也可以对右心衰竭等心脏疾病起到辅助治疗的作用.