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41.
Sachiko HYOKAI Hiroyo TANAKA Noriyuki AIHARA Junichi KAMIIE 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(3):473
In canine lymphoma, drug resistance is the major factor hindering treatment. In this study, we performed immunohistochemical examination of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), which are considered as transporters related to multidrug resistance in three recurrent canine lymphomas. All cases were negative for both transporters before anticancer drug administration, but became positive after this administration. The expression was confirmed in capillary endothelial cells, such as in brain capillaries acting as the blood-brain barrier (BBB). It is suggested that both transporters expressed on capillary endothelial cells in lymphoma tissue may inhibit the spread of anticancer drugs into tumor tissues from blood, the same as the BBB. Therefore, capillary endothelial cells could act as a blood-tumor barrier, which might be involved in drug resistance in canine lymphoma. 相似文献
42.
低聚原花色素对高温环境下肉鸡抗氧化酶及胸肌品质的影响 总被引:2,自引:2,他引:2
作者旨在研究低聚原花色素(oligomeric proanthocyanidins,OPC)对夏季肉鸡体内抗氧化酶及胸肌品质的影响。将144只28日龄的AA肉用公鸡分为4个处理组,每个处理组6个重复,每个重复6只鸡。分别饲喂含0、50、100、200 mg/kg OPC的4种日粮,饲养于7月中旬高温季节,试验持续3周。研究结果发现,100、200 mg/kg OPC显著提高肉鸡血清、肝脏中的SOD、GSH-Px酶活性(P<0.05),但对CAT酶无显著影响。100、200 mg/kg OPC显著降低血清CK酶的活性(P<0.05),50 mg/kg以上OPC显著降低血清、肝脏中的MDA含量(P<0.05),同时200 mg/kg OPC显著提高肉鸡胸肌pHi,100、200 mg/kg OPC显著降低胸肌L*值、滴水损失和剪切力值(P<0.05),不同剂量OPC对pHu、肉色a*值和b*值的影响未达到显著水平。研究结果表明,低聚原花色素可上调肉鸡体内的抗氧化酶,降低体内脂质过氧化物的含量,维持肌纤维膜的完整性。这种作用可能与二氢杨梅素改善胸肌肉色、滴水损失和嫩度有关。 相似文献
43.
采用RNG k-ε紊流数值模型对具有不同坡度的胸墙压坡段的泄洪闸出口水流进行了三维数值模拟.通过数值模拟计算得到了具有4种不同坡度的泄洪闸胸墙压坡段的流线、流速和压力,并对比分析了胸墙压坡段坡度变化对泄洪闸泄流能力、水流脱壁情况、负压分布区域的影响情况.研究结果表明:随着胸墙压坡段坡度的增大,虽然闸口的泄流能力减弱,但是出口水流的脱空长度和脱空高度变小,也即增大胸墙压坡段的坡度使得出口水流的脱壁现象减弱直至消失;胸墙压坡段内的负压最值及负压的分布区域均随着坡度的增大而变小.在泄洪闸胸墙底缘压坡段的设计过程中要避免平坡式链接,可通过合理的方式比选出适用于自身工程的压坡坡度,有利于提高消力池的消能效率,避免压坡段的空化空蚀,从而增强了工程的安全性.研究方法和结果对类似工程的优化设计及安全运行具有一定的指导意义. 相似文献
44.
The objective of this study was to investigate the effect of storage temperatures and time on discoloration and oxidation of prepared chicken breast with paprika oleoresin. Freshly prepared chicken breast containing paprika oleoresin was stored at ?2, ?10, ?18°C, and an oscillating temperature between ?10 and ?18°C (?10/?18°C). A significant decrease in redness was detected at ?2, ?10, and ?10/?18°C. The lowest TBARS values and carbonyl contents were observed in the samples stored at ?18°C for 5 weeks. Also, the values of sulfhydryl groups gradually decreased with the increase in storage temperatures and duration. The results suggest a positive correlation between the loss of redness and oxidation in all samples. The findings indicated that the discoloration and oxidation of prepared chicken breast added with paprika oleoresin were inhibited significantly when stored at ?18°C. 相似文献
45.
Rmi Cousin Hugo Groult Chanez Manseur Romain Ferru-Clment Mario Gani Rachel Havret Claire Toucheteau Grgoire Prunier Batrice Colin Franck Morel Jean-Marie Piot Isabelle Lanneluc Kvin Baranger Thierry Maugard Ingrid Fruitier-Arnaudin 《Marine drugs》2021,19(10)
Sugar-based molecules such as heparins or natural heparan sulfate polysaccharides have been developed and widely studied for controlling heparanase (HPSE) enzymatic activity, a key player in extracellular matrix remodelling during cancer pathogenesis. However, non-enzymatic functions of HPSE have also been described in tumour mechanisms. Given their versatile properties, we hypothesized that sugar-based inhibitors may interfere with enzymatic but also non-enzymatic HPSE activities. In this work, we assessed the effects of an original marine λ-carrageenan derived oligosaccharide (λ-CO) we previously described, along with those of its native counterpart and heparins, on cell viability, proliferation, migration, and invasion of MDA-MB-231 breast cancer cells but also of sh-MDA-MB-231 cells, in which the expression of HPSE was selectively downregulated. We observed no cytotoxic and no anti-proliferative effects of our compounds but surprisingly λ-CO was the most efficient to reduce cell migration and invasion compared with heparins, and in a HPSE-dependent manner. We provided evidence that λ-CO tightly controlled a HPSE/MMP-14/MMP-2 axis, leading to reduced MMP-2 activity. Altogether, this study highlights λ-CO as a potent HPSE “modulator” capable of reducing not only the enzymatic activity of HPSE but also the functions controlled by the HPSE levels. 相似文献
46.
笼底材料、密度和性别组群对肉鸡胸囊肿发生及胸肌成分的影响 总被引:1,自引:2,他引:1
该研究采用了三因素三水平的正交试验设计,就笼底材料、饲养密度、性别组群等三因素对3~6周龄笼养AA肉仔鸡发生胸囊肿及对其胸肌成分的影响进行了研究。结果表明:铁丝笼底、高饲养密度(17.25只/m2)、公鸡组的发病率最高,平均达34.09%,并显著高于其他组(P<0.05)。铁丝笼底显著高于塑料和竹竿笼底(P<0.05),高密度(17.25只/m2)显著高于低密度(10.98只/m2)(P<0.05),笼底材料是导致胸囊肿发病的主要环境因素,而性别组群对其无显著影响(P>0.05)。不同笼底下胸肌水分和蛋白质含量以竹竿笼底的含量最高,铁丝笼底下的胸肌蛋白含量最低(P<0.05)。胸肌脂肪则不受笼底、密度和性别组群的影响。因此,该试验表明,竹竿笼底和塑料笼底材料可降低笼养肉仔鸡胸囊肿的发病率,有利于提高其胸肌品质。 相似文献
47.
Weidong SUN Xu YANG Hengbin QIU Di ZHANG Huanan WANG Jian HUANG Degui LIN 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(11):1541-1543
The BRCA1 gene plays an important role in the development of human breast
cancer, and recent research indicated that genetic variations of BRCA1 are also related to
canine mammary tumors (CMTs). Here, using rapid amplification of cDNA ends (RACE), we
cloned the 5′- and 3′-UTRs of BRCA1. By direct sequencing of the flanking sequences of the
5′- and 3′-UTRs of BRCA1, three previously unreported single-nucleotide polymorphisms
(SNPs) were identified, two (−1228T >C, −1173C >T) in the putative promoter regions
and one non-synonymous SNP (63449G >A) in exon 23. Compared with 16 normal samples, the
sequences from 34 CMTs suggested that SNP (−1173C >T) was associated with the
development of CMTs (odds ratio (OR)=2.57, 95% confidence interval (CI): 1.07–6.15). 相似文献
48.
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50.
四川的云南松地径胸径相关关系及其应用研究 总被引:8,自引:1,他引:8
本文报道了四川的云南松树干在部三个不同部位直径(地表直径d0.00、0.05m高处直径d0.05、0.1Om高处直径d0.10)与胸径(d1.3)的相关关系,利用其编制了四川云南松地径一元材积表,并对其在四川云南松林区进行盗伐木、滥砍乱伐木材积估计和监测森林资源消耗量等方面的应用进行了探讨。四川云南松地径与胸径最佳关系模型为二次抛物线回归方程,相关系数r=0,999217~0.999380,剩余平方和Q=179.3391~226.4480,且d0.10与d1.3相关关系最为紧密。 相似文献