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Hyun-Soo Kim Jun-Geon Je Hyesuck An Kyunghwa Baek Jeong Min Lee Mi-Jin Yim Seok-Chun Ko Ji-Yul Kim Gun-Woo Oh Min-Cheol Kang Young Min Ham You-Jin Jeon Dae-Sung Lee 《Marine drugs》2022,20(8)
Ecklonia maxima is a brown seaweed, which is abundantly distributed in South Africa. This study investigated an efficient approach using high-performance centrifugal partition chromatography (HPCPC), which has been successfully developed for the isolation and purification of phlorotannins, eckmaxol, and dieckol from the ethyl acetate fraction of E. maxima (EEM). We evaluated EEM for its inhibitory effect against lipopolysaccharide (LPS)-induced inflammatory responses in zebrafish embryos. The separation of eckmaxol and dieckol from samples of EEM using HPCPC was found to be of high purity and yield under an optimal solvent system composed of n-hexane:ethyl acetate:methanol:water (2:7:3:7, v/v/v/v). To evaluate the anti-inflammatory efficacy of EEM containing active compounds, zebrafish embryos exposed to LPS were compared with and without EEM treatment for nitric oxide (NO) production, reactive oxygen species (ROS) generation, and cell death two days after fertilization. These evaluations indicate that EEM alleviated inflammation by inhibiting cell death, ROS, and NO generation induced by LPS treatment. According to these results, eckmaxol and dieckol isolated from brown seaweed E. maxima could be considered effective anti-inflammatory agents as pharmaceutical and functional food ingredients. 相似文献
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Jill A. Richardson DVM Rachel A. Balabuszko CVT 《Journal of Veterinary Emergency and Critical Care》2001,11(1):53-58.
Objective: To summarize typical clinical signs, characterize the anticipated course of action, and give treatment recommendations for ibuprofen ingestion in ferrets.
Design: Retrospective study
Patients: Records of 43 cases of ibuprofen ingestion in ferrets that were reported between January 1996-March 2000, to the ASPCA Animal Poison Control Center (APCC).
Measurements and Main Results: Twenty-seven (93.1%) ferrets that had ingested ibuprofen developed neurologic signs, such as depression, coma, ataxia, recumbency, tremors, and weakness. In addition, 16 cases (55.2%) had one or more GI effects including anorexia, vomiting, retching or gagging, diarrhea, and melena. Polydipsia, polyuria, dysuria, renal failure, weight loss, shallow breathing, metabolic acidosis, dehydration, and hypothermia were also reported. Death was reported in 4 cases. The lowest dose associated with death was 220 mg/kg.
Conclusion: Data in this study indicate that clinical signs of ibuprofen toxicosis in ferrets are more severe than those expected at similar dosages in dogs. The reason for this difference is poorly understood since the pathophysiology of ibuprofen is relatively unknown in ferrets. The onset of clinical signs appeared to occurr soon after ingestion and the toxic effects in ferrets typically involve the CNS, GI and renal systems. Treatment for ibuprofen toxicosis in the ferret includes stabilization, gastrointestinal decontamination, fluid diuresis, GI protection, and supportive care.(J Vet Emerg Crit Care 2001; 11(1):53–59) 相似文献
Design: Retrospective study
Patients: Records of 43 cases of ibuprofen ingestion in ferrets that were reported between January 1996-March 2000, to the ASPCA Animal Poison Control Center (APCC).
Measurements and Main Results: Twenty-seven (93.1%) ferrets that had ingested ibuprofen developed neurologic signs, such as depression, coma, ataxia, recumbency, tremors, and weakness. In addition, 16 cases (55.2%) had one or more GI effects including anorexia, vomiting, retching or gagging, diarrhea, and melena. Polydipsia, polyuria, dysuria, renal failure, weight loss, shallow breathing, metabolic acidosis, dehydration, and hypothermia were also reported. Death was reported in 4 cases. The lowest dose associated with death was 220 mg/kg.
Conclusion: Data in this study indicate that clinical signs of ibuprofen toxicosis in ferrets are more severe than those expected at similar dosages in dogs. The reason for this difference is poorly understood since the pathophysiology of ibuprofen is relatively unknown in ferrets. The onset of clinical signs appeared to occurr soon after ingestion and the toxic effects in ferrets typically involve the CNS, GI and renal systems. Treatment for ibuprofen toxicosis in the ferret includes stabilization, gastrointestinal decontamination, fluid diuresis, GI protection, and supportive care.(J Vet Emerg Crit Care 2001; 11(1):53–59) 相似文献
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Eight new cembranoids, crassarines A-H (1-8) were isolated from the Formosan soft coral Sinularia crassa. Compounds 1-3 represent the rare cembranoids with a 1,12-oxa-bridged tetrahydrofuran ring, while 4 and 5 are the firstly discovered 1,11-oxa-bridged tetrahydropyranocembranoids. The absolute configuration of 6 was determined using the Mosher's method. Compounds 6 and 8 were found to significantly inhibit the expression of both pro-inflammatory iNOS and COX-2 proteins at 10 μM, respectively, while compounds 4-8 were found to be non-cytotoxic toward the selected human liver cancer cells. 相似文献
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Four new eunicellin-based diterpenoids, krempfielins A-D (1-4), along with two known compounds (5 and 6) have been isolated from a soft coral Cladiella krempfi. The structures of the new metabolites were elucidated by extensive spectroscopic analysis and by comparison with spectroscopic data of related known compounds. Compounds 5 and 6 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines. Furthermore, compounds 2, 3, 5 and 6 were shown to exert significant in vitro anti-inflammatory activity against LPS-stimulated RAW264.7 macrophage cells. 相似文献
18.
Chatter R Ben Othman R Rabhi S Kladi M Tarhouni S Vagias C Roussis V Guizani-Tabbane L Kharrat R 《Marine drugs》2011,9(7):1293-1306
Neorogioltriol is a tricyclic brominated diterpenoid isolated from the organic extract of the red algae Laurencia glandulifera. In the present study, the anti-inflammatory effects of neorogioltriol were evaluated both in vivo using carrageenan-induced paw edema and in vitro on lipopolysaccharide (LPS)-treated Raw264.7 macrophages. The in vivo study demonstrated that the administration of 1 mg/kg of neorogioltriol resulted in the significant reduction of carregeenan-induced rat edema. In vitro, our results show that neorogioltriol treatment decreased the luciferase activity in LPS-stimulated Raw264.7 cells, stably transfected with the NF-κB-dependent luciferase reporter. This effect on NF-κB activation is not mediated through MAPK pathways. The inhibition of NF-κB activity correlates with decreased levels of LPS-induced tumor necrosis factor-alpha (TNFα) present in neorogioltriol treated supernatant cell culture. Further analyses indicated that this product also significantly inhibited the release of nitric oxide and the expression of cyclooxygenase-2 (COX-2) in LPS-stimulated Raw264.7 cells. These latter effects could only be observed for neorogioltriol concentrations below 62.5 μM. To our knowledge, this is the first report describing a molecule derived from Laurencia glandulifera with anti-inflammatory activity both in vivo and in vitro. The effect demonstrated in vitro may be explained by the inhibition of the LPS-induced NF-κB activation and TNFα production. NO release and COX-2 expression may reinforce this effect. 相似文献
19.
Muhammad Dawood Shah Balu Alagar Venmathi Maran Sitti Raehanah Muhamad Shaleh Wahidatul Husna Zuldin Charles Gnanaraj Yoong Soon Yong 《Marine drugs》2022,20(2)
Malaysia has a long coastline surrounded by various islands, including North Borneo, that provide a suitable environment for the growth of diverse species of seaweeds. Some of the important North Bornean seaweed species are Kappaphycus alvarezii, Eucheuma denticulatum, Halymenia durvillaei (Rhodophyta), Caulerpa lentillifera, Caulerpa racemosa (Chlorophyta), Dictyota dichotoma and Sargassum polycystum (Ochrophyta). This review aims to highlight the therapeutic potential of North Bornean seaweeds and their nutraceutical profiling. North Bornean seaweeds have demonstrated anti-inflammatory, antioxidant, antimicrobial, anticancer, cardiovascular protective, neuroprotective, renal protective and hepatic protective potentials. The protective roles of the seaweeds might be due to the presence of a wide variety of nutraceuticals, including phthalic anhydride, 3,4-ethylenedioxythiophene, 2-pentylthiophene, furoic acid (K. alvarezii), eicosapentaenoic acid, palmitoleic acid, fucoxanthin, β-carotene (E. denticulatum), eucalyptol, oleic acid, dodecanal, pentadecane (H. durvillaei), canthaxanthin, oleic acid, pentadecanoic acid, eicosane (C. lentillifera), pseudoephedrine, palmitic acid, monocaprin (C. racemosa), dictyohydroperoxide, squalene, fucosterol, saringosterol (D. dichotoma), and lutein, neophytadiene, cholest-4-en-3-one and cis-vaccenic acid (S. polycystum). Extensive studies on the seaweed isolates are highly recommended to understand their bioactivity and mechanisms of action, while highlighting their commercialization potential. 相似文献
20.
Chia-Chi Peng Chiung-Yao Huang Atallah F. Ahmed Tsong-Long Hwang Jyh-Horng Sheu 《Marine drugs》2020,18(11)
The present investigation on chemical constituents of the soft coral Sarcophyton cherbonnieri resulted in the isolation of seven new cembranoids, cherbonolides F–L (1–7). The chemical structures of 1–7 were determined by spectroscopic methods, including infrared, one- and two-dimensional (1D and 2D) NMR (COSY, HSQC, HMBC, and NOESY), MS experiments, and a chemical reduction of hydroperoxide by triphenylphosphine. The anti-inflammatory activities of 1–7 against neutrophil proinflammatory responses were evaluated by measuring their inhibitory ability toward N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced superoxide anion generation and elastase release in primary human neutrophils. The results showed that all isolates exhibited moderate activities, while cherbonolide G (2) and cherbonolide H (3) displayed a more active effect than others on the inhibition of elastase release (48.2% ± 6.2%) and superoxide anion generation (44.5% ± 4.6%) at 30 µM, respectively. 相似文献