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91.
The aim of this study was to determine the blood flow in the carotid artery during halothane anaesthesia by means of duplex-sonography. Seventeen warm blood horses were evaluated in dorsal and lateral recumbency and the results were compared with the values of the same horses resting and under sedation. The cross sectional area of the vessels, the time-averaged maximal blood velocity, time-averaged maximal blood flow and the resistance index were determined and the flow profile was evaluated. During halothane anesthesia the total blood flow shows a significant increase which is not dependent on the positioning of the horse. Mean blood velocity is decreased by sedation and significantly increased during anesthesia. Reduced peripheral resistance is expressed by a decline of the resistance index. After sedation and during recumbency there is an increase in diameter of the carotid artery.  相似文献   
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本实验用3-6岁的驴6头,先以每百公斤体重1.8mL 剂量肌注保定宁,取得呼吸、心率、体温等数据以供对照。过两天后,再在同一驴上仍以同样剂量肌注保定宁5min后,随以每公斤体重2.2mg 剂量静注盐酸氯胺酮复合麻醉。结果表明,两药复合后,氯胺酮对保定宁引起的心血管抑制有一定的颉顽作用,特别是在麻醉初期作用较显著,但促使呼吸更加加快,尤其给药初期更甚,以致出现呼吸困难和暂时危急症状。两药复合后动物会迅速倒地,诱导期短,能平稳地进入麻醉期,麻醉期可维持21±1.41min,苏醒期亦平静。因此,可以认为两药复合应用,是一种安全实用的麻醉方法。  相似文献   
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ObjectiveTo determine the effects of propofol or etomidate on induction quality, arterial blood pressure, blood gases, and recovery quality in normal dogs.Study designRandomized, blinded trial.AnimalsEighteen purpose-bred adult Beagles.MethodsDogs were randomly assigned to receive propofol at 8 mg kg−1 or etomidate at 4 mg kg−1 intravenously (IV) administered to effect. Midazolam was administered at 0.3 mg kg−1 IV as pre-medication at least 1 minute prior to induction. Direct arterial blood pressure, arterial blood gases, and heart rate were obtained at baseline, before induction, after induction, and for every 5 minutes afterwards until the dog began to swallow and the trachea was extubated. The dogs were allowed to breathe room air with the endotracheal tube in place.ResultsThe systolic arterial pressure (SAP) was higher in the etomidate group compared with the propofol group after induction. The SAP and mean arterial pressure (MAP) were higher in the etomidate group compared with the propofol group at 5 minutes. The recovery quality and ataxia score were worse in the etomidate group compared with the propofol group. Time from extubation to sternal recumbency and sternal recumbency to standing was longer in the etomidate group compared with the propofol group. The heart rate, PaCO2, and HCO3 were higher in the propofol group compared with the etomidate group after induction. The PaO2 and SaO2 were lower in the propofol group compared with the etomidate group after induction. The SAP and MAP were lower in the propofol group at 5 minutes compared with baseline.Conclusion and clinical relevancePropofol caused a decrease in SAP and MAP which was not observed with etomidate. Etomidate caused longer and poorer recoveries than propofol.  相似文献   
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Objective

Orbital and globe surgeries are commonly performed in companion animals and are considered to cause moderate to severe pain. Regional anesthesia techniques can provide complete sensory blockade, analgesia for painful procedures and improve surgical conditions. The purpose of this review is to summarize local and regional anesthesia techniques for ophthalmic surgery in dogs and cats with emphasis on veterinary publications in the past 12 years.

Databases used

Review of the literature was conducted using PubMed and Google Scholar. The search terms were ‘ophthalmic regional anesthesia’, ‘retrobulbar anesthesia’, ‘peribulbar anesthesia’, ‘sub-Tenon’s anesthesia’, ‘intracameral anesthesia’, ‘eye infiltration’, ‘dogs’ and ‘cats’. Further studies and reports were obtained from the reference lists of the retrieved papers. In addition, related veterinary anatomy, ophthalmology and regional anesthesia books were reviewed.

Conclusions

Reported techniques include regional techniques such as retrobulbar anesthesia, peribulbar anesthesia and sub-Tenon’s anesthesia, and local techniques such as eyelid and conjunctival infiltration, intracameral anesthesia, splash block and insertion of intraorbital absorbable gelatin sponge infused with local anesthetic. Administration guidelines, indications and contraindications, and complications of each technique are discussed. Regional anesthesia techniques were reported to be effective during ophthalmic surgeries and are recommended for use as part of the anesthetic regimen and pain management in animals. However, the veterinary literature is still lacking controlled clinical trials and adverse events reports; therefore, there is very little evidence for choosing one technique over another.  相似文献   
97.

Objective

To determine the effect of fentanyl on the induction dose and minimum infusion rate of alfaxalone required to prevent movement in response to a noxious stimulus (MIRNM) in dogs.

Study design

Experimental crossover design.

Animals

A group of six healthy, adult, intact female mixed-breed dogs, weighing 19.7 ± 1.3 kg.

Methods

Dogs were randomly administered one of three treatments at weekly intervals: premedication with 0.9% saline (treatment A), fentanyl 5 μg kg–1 (treatment ALF) or fentanyl 10 μg kg–1 (treatment AHF), administered intravenously over 5 minutes. Anesthesia was induced 5 minutes later with incremental doses of alfaxalone to achieve intubation and was maintained for 90 minutes in A with alfaxalone (0.12 mg kg–1 minute–1), in ALF with alfaxalone (0.09 mg kg–1 minute–1) and fentanyl (0.1 μg kg–1 minute–1) and in AHF with alfaxalone (0.06 mg kg–1 minute–1) and fentanyl (0.2 μg kg–1 minute–1). The alfaxalone infusion was increased or decreased by 0.006 mg kg–1 minute–1 based on positive or negative response to antebrachium stimulation (50 V, 50 Hz, 10 ms). Data were analyzed using a mixed-model anova and presented as least squares means ± standard error.

Results

Alfaxalone induction doses were 3.50 ± 0.13 (A), 2.17 ± 0.10 (ALF) and 1.67 ± 0.10 mg kg–1 (AHF) and differed among treatments (p < 0.05). Alfaxalone MIRNM was 0.17 ± 0.01 (A), 0.10 ± 0.01 (ALF) and 0.07 ± 0.01 mg kg–1 minute–1 (AHF) and differed among treatments. ALF and AHF decreased the MIRNM by 44 ± 8% and 62 ± 5%, respectively (p < 0.05). Plasma alfaxalone concentrations at MIRNM were 5.82 ± 0.48 (A), 4.40 ± 0.34 (ALF) and 2.28 ± 0.09 μg mL–1 (AHF).

Conclusions and clinical relevance

Fentanyl, at the doses studied, significantly decreased the alfaxalone induction dose and MIRNM.  相似文献   
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