Accuracy of genomic prediction using imputed whole‐genome sequence data in white layers

There is an increasing interest in using whole‐genome sequence data in genomic selection breeding programmes. Prediction of breeding values is expected to be more accurate when whole‐genome sequence is used, because the causal mutations are assumed to be in the data. We performed genomic prediction for the number of eggs in white layers using imputed whole‐genome resequence data including ~4.6 million SNPs. The prediction accuracies based on sequence data were compared with the accuracies from the 60 K SNP panel. Predictions were based on genomic best linear unbiased prediction (GBLUP) as well as a Bayesian variable selection model (BayesC). Moreover, the prediction accuracy from using different types of variants (synonymous, non‐synonymous and non‐coding SNPs) was evaluated. Genomic prediction using the 60 K SNP panel resulted in a prediction accuracy of 0.74 when GBLUP was applied. With sequence data, there was a small increase (~1%) in prediction accuracy over the 60 K genotypes. With both 60 K SNP panel and sequence data, GBLUP slightly outperformed BayesC in predicting the breeding values. Selection of SNPs more likely to affect the phenotype (i.e. non‐synonymous SNPs) did not improve the accuracy of genomic prediction. The fact that sequence data were based on imputation from a small number of sequenced animals may have limited the potential to improve the prediction accuracy. A small reference population (n = 1004) and possible exclusion of many causal SNPs during quality control can be other possible reasons for limited benefit of sequence data. We expect, however, that the limited improvement is because the 60 K SNP panel was already sufficiently dense to accurately determine the relationships between animals in our data.     

对北京市新型农村合作医疗制度的调查与思考

自2002年7月北京市大兴区率先在全国开展新型合作医疗试点至今,北京市新型农村合作医疗制度运行已经5年了.在对北京市新型农村合作医疗制度运行情况进行充分调研的基础上,总结了所取得的成效,分析了存在的问题,要进一步完善这项制度应提高筹资水平,实行动态缴费;提高补偿水平,提升制度吸引力;充实管办资源,重视调研能力建设等.     

对农村老年人口养老的主要问题分析

目前农村老年人养老现状不容乐观.家庭养老功能弱化,社区养老机制滞后,社会福利、政府救济和低保投入严重不足等,导致绝大多数农村老年人处在家庭边缘和社会保障体系之外.     

农村公共产品供给与减轻农民负担

农民负担实际上是与农民有关的公共产品成本的分摊，而这种分摊存在着体制缺陷，这种缺陷导致了农民的生产效益低下，农民负担逐步加重。要改变这种现状就必须对农村公共产品供给体制进行改革和完善，以期从根本上减轻农民负担。     

An Information System for Vehicle Transport Management

This paper proposes a model framework, which describes the function requirements and the common characterstics of vehicle transport management. With the frame, a computer vehicle transportation managerment information system(QCMIS)is in troduced here and it has already been put into practice. The key technical points is also explained in the paper.     

Model of Financing Strategy

Considering information asymmetry between inside and outside of the firms,this paper discusses the financing strategy of M&A,and builds a model.According to the model,we can see that the firm with relatively expected low-productivity will choose equity financing for M&A,and the firm with relatively expected high-productivity will choose debt financing for M&A,and the firm with expected medium-productivity will not choose financing from outside.In the case of undeveloped capital market and financing tools in China,the conclusion of the model has some extent significance for helping firms to choose financing strategy for M&A rationally.     

On the Development of Urban Spatial Structure in the Information Age

Today the information globalization is the trend of society development. The information technology has great influence not only on the mode of life and production, but also on the urban social and economic structure. In order to fit in with the change in this regard, the urban land-use distribution, residential mode, traffic pattern and so on should be changed correspondingly. Therefore, this change will lead to the development and evolution of whole urban spatial structure. In this paper, the development tendency of urban spatial structure in the information age is analyzed and some proposals on city planning and construction are put forward.     

Enterprise Information Engineering Model and Its Integrated Support Environment

By analyzing the process of enterprise information engineering construction and intra relationship among information system requirement, business process modeling, application system constructing and project management, one of 4 meta model composed of requirement engineering, process engineering, application system engineering and support engineering is proposed for enterprise information engineering. The developments and applications of the business processes and its application systems are integrated into the same development space and application space. Basing on this, a prototype system composed of requirement modeling environment, business process modeling environment, application system modeling environment, and support engineering environment has been designed and built, which is used for supporting enterprise information engineering constructing. It is valued for the enterprise information engineering construction in our country.     

Office Automation System for the University

The solution of the office automation system for the universities is given. The detail steps on developing an office automation system through Lotus Notes are described.