A multicentric retrospective study of serum/plasma urea and creatinine concentrations in dogs using univariate and multivariate decision rules to evaluate diagnostic efficiency

BACKGROUND: Urea and creatinine are the most frequently used indirect markers in plasma and serum of glomerular filtration rate in dogs. Both have been shown to lack sensitivity but their diagnostic efficiency for the diagnosis of kidney disease has been minimally investigated. OBJECTIVE: The purpose of this retrospective study was to investigate the influence of possible factors of variation on both analytes and to determine whether specific decision rules should be drawn up for subpopulations of dogs. METHODS: The results of urea and creatinine measurements, breed, sex, age, and health status (healthy, renal disease, or nonrenal disease) of 3822 dogs were collected from the archives of 5 veterinary clinics. Data were analyzed with univariate and multivariate decision rules with and without adjustment. RESULTS: There were significant effects and interactions of almost all of the sources of variation. Slight improvements in diagnostic efficiency were obtained by adjusting the decision rules to these sources of variations. Univariate decision rules gave approximately the same diagnostic efficiency for urea and creatinine concentrations, with sensitivity and specificity in the range of 70% and 90%, respectively, using the upper limit of the reference interval as the threshold value. Multivariate decision rules provided only minor improvements in diagnostic efficiency. CONCLUSION: Simultaneous measurement of both urea and creatinine is of limited diagnostic value over the analysis of a single variable. Creatinine is the preferred analyte as it is affected by fewer extrarenal factors of variation.     

改善奶牛氮磷利用效率的营养策略

氮磷在奶牛生长、发育和生产过程中发挥着重要作用,但在实际生产中,饲粮氮磷含量往往过高,而奶牛对于氮磷的利用效率普遍偏低,这不仅会造成饲料资源的浪费,而且加重了氮磷的排放,导致严重的环境污染.合理减少饲粮氮磷含量、提高奶牛机体对氮磷的利用效率具有重要的现实意义.因此,本文主要从影响氮磷利用效率的因素,以及改善奶牛氮磷利用效率的营养策略2个方面进行了综述,以期为提高奶牛氮磷利用效率,减少氮磷向环境的排放,提高奶牛场经济和生态效益提供理论依据.     

Selecting the hologenome to breed for an improved feed efficiency in pigs—A novel selection index

Most traits in animal breeding, including feed efficiency traits in pigs, are affected by many genes with small effect and have a moderately high heritability between 0.1 and 0.5, which enables efficient selection. Since the microbiota composition in the gastrointestinal tract is also partly heritable and was shown to have a substantial effect on feed efficiency, the host genes affect the phenotype not only directly by altering metabolic pathways, but also indirectly by changing the microbiota composition. The effect of the microbiota composition on the breeding value of an animal is the conditional expectation of its breeding value, given the vector with microbiota frequencies, that is The breeding value of an animal can therefore be decomposed into a heritable contribution that arises from an altered microbiota composition and a heritable contribution that arises from altered metabolic pathways within the animal, so Instead of selecting for breeding value , an index comprising the two components and with appropriate weights, that is , can be used. The present study shows how this breeding strategy can be applied in pig genomic selection breeding scheme for two feed efficiency traits and daily gain.     

关于藏书倒架的研究与探讨——以中国矿业大学图书馆文昌科技图书阅览室为例

结合工作实际探讨藏书倒架的前期准备工作及倒架时的路线设计、人员组织安排和倒架后的环节完善。以期减轻图书馆人员在倒架工作中的劳动强度和工作量，提高工作效率。     

血吸虫疫苗研究现状和发展方向

血吸虫疫苗的研究工作已经进行了很长一段时间,发现了一批有价值的候选疫苗分子。同时通过改进和优化免疫途径,血吸虫疫苗的免疫保护力正在逐步提高。随着研究的日益深入,对血吸虫疫苗的免疫机制等了解更加透彻,距离研制出能诱导高的、稳定的免疫保护力的疫苗分子的目标将越来越近。     

血吸虫疫苗研究现状和发展方向

血吸虫疫苗的研究工作已经进行了很长一段时间,发现了一批有价值的候选疫苗分子。同时通过改进和优化免疫途径,血吸虫疫苗的免疫保护力正在逐步提高。随着研究的日益深入,对血吸虫疫苗的免疫机制等了解更加透彻,距离研制出能诱导高的、稳定的免疫保护力的疫苗分子的目标将越来越近。     

羊高频高效繁育调控技术应用现状和操作要点

阐述了羊高频高效繁育调控技术的国内外研究应用现状,并结合生产实践总结出羊高频高校繁育调控技术操作程序及要点,其内容包括：羊的同期发情、多胎技术、精液解冻及镜检、输精前处理、腹腔镜观察卵巢状况、腹腔镜子宫内输精、早期妊娠诊断、羔羊代乳粉、羔羊早期断奶等技术和方法。     

太原经济技术开发区用地效益评价

通过对太原经济技术开发区的实际调查和对2002—2011年10 a间的相关统计及国家商务部历年发布的国家级经济技术开发区发展报告的信息进行分析,从开发区土地利用现状、年度建设用地供给、科工贸收入、工业总产值、GDP、税收收入、国内外资金利用等方面,综合评价了太原经济技术开发区的经济效益和用地效益。结果表明,该区独立运行10 a来成绩显著,整体效益逐步提高,在山西所有开发区中经济效益名列前茅,在全省经济技术开发区中每年的综合评价都名列第1;与国内中西部或中部的同类开发区相比,该区经济总量和单位面积产生的效益排名中后;与国内先进经济技术开发区相比,差距较大;该区内部分企业规模大、影响广泛,经济效益和用地效益均好,起到了带头和示范作用,但仍有部分企业规模小、投入水平低、建设周期长、产生效益低,影响了全区整体效益的发挥。建议开发区管委会引导入区企业加大投入,加快建设步伐,及早产生经济效益;尽快实施扩区计划,保证经济快速、健康发展;落实土地供给和退出政策,使有限的土地发挥更大的效益。     

地温空调井抽回灌效果影响关键因子识别

为了探析引起地温空调井抽回灌效果的主要制约因素,通过单相关系数分析、主成分绝对得分的源解析模型、拟合度检验和多元线性回归的方法分析影响单井回灌效率的影响因素。结果表明:井径、滤水管孔隙率及抽回灌井数比与单井回灌效率的相关性和拟合度较好,故将井径、滤水管孔隙率及抽回灌井数比作为影响单井回灌效率的关键因子,同时分析了单井回灌效率与关键因子的之间的拟合方程及多元线性回归方程,得到了单井回灌效率与关键因子之间的定量关系。     

水头可调薄壁堰式渠道流量智能测控系统优化试验研究

采用巴赞堰流公式计算流量的水头可调薄壁堰式渠道流量智能测控系统通过渠道流量量测与控制试验,验证了其精准的测流功能和智能控制技术的可行性。为进一步提高该测控系统运行的效率和稳定性,减少运行能耗,对矩形薄壁堰堰流公式进行水力试验研究,通过分析堰上水头和流量关系,拟合出矩形薄壁堰流量计算公式。通过向该拟合公式引入修正系数λ=0.848,将测控系统测得的堰上水头数据值代入该拟合公式求得的流量值与电磁流量计测得流量值的差值的平均值为-0.004L/s,标准差为0.119,线性相关系数R2=0.989 1。该拟合公式相对于巴赞堰流公式形式简单、参数较少、运算简便,同时也满足节水灌溉对精准测流的要求,更适用于水头可调薄壁堰式渠道流量智能测控系统,对于在灌区推广和使用该测控系统具有重要的意义。