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排序方式: 共有701条查询结果,搜索用时 46 毫秒
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Roger G. Pertwee 《Euphytica》2004,140(1-2):73-82
Summary Cannabis is the unique source of a set of at least 66 compounds known collectively as cannabinoids. Of these, most is known about the pharmacology of 9-tetrahydrocannabinol (9-THC), the main psychoactive constituent of cannabis, and about cannabidiol (CBD), which lacks psychoactivity. Accordingly, this paper focuses on the pharmacological and therapeutic targets of these two cannabinoids. Many of the effects of 9-THC are mediated by cannabinoid receptors of which at least two types, CB1 and CB2, are present in mammalian tissues. Endogenous agonists for cannabinoid receptors have also been discovered. CB1 receptors are present at the terminals of central and peripheral neurones, where they modulate transmitter release. They also exist in some non-neuronal cells. CB2 receptors are expressed mainly by immune cells, one of their roles being to alter cytokine release. 9-THC also appears to have non-CB1, non-CB2 pharmacological targets. It is already licensed for clinical use in the U.S.A. as an anti-emetic and appetite stimulant and both 9-THC and 9-THC-rich cannabis extracts show therapeutic potential as neuroprotective and anticancer agents and for the management of glaucoma, pain and various kinds of motor dysfunction associated, for example, with multiple sclerosis and spinal cord injury. CBD has much less affinity for CB1 and CB2 receptors than 9-THC and its pharmacological actions have been less well characterized. Potential clinical applications of CBD and CBD-rich cannabis extracts include the production of anti-inflammatory and neuroprotective effects, the management of epilepsy, anxiety disorders, glaucoma and nausea, and the modulation of some effects of 9-THC. 相似文献
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Our objectives were to explain the prospects and constraints of applying empirical models that relate bird community metrics to broad-scale characteristics of roads and development. We explored the practical value of regression models that were derived for a large protected area in the Chihuahuan Desert. These models related bird species richness, relative abundance, or probability of occurrence to total length of roads within each of two spatial extents (1- and 2-km radii), distance to the nearest road, distance to the nearest development, or the two-way interactions of these variables. Empirical models can be used to inform conservation decisions, to parameterise simulation models for conservation planning, to identify threshold levels of road and development variables, and to determine the focus of management experiments for confirmatory hypothesis testing and improvement of model realism. 相似文献
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“3S”技术在水土保持工作中的应用及展望 总被引:6,自引:0,他引:6
随着遥感(RS)、地理信息系统(GIS)与全球定位系统(GPS)三项技术的飞速发展,其在水土保持工作中的应用也得到不断加强。基于“3S”技术在水土保持工作中的应用,提出了“3S”技术的集成构想,最后对“3S”技术在水土保持中的应用做了相应的展望。 相似文献
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免耕播种机在残茬覆盖地作业是否具备良好的防堵性能,已成为影响免耕播种机生产效率和播种质量的关键因素之一.该文系统分析了免耕播种机防堵的必要性和防堵技术研究现状,提出了免耕播种机应着手找准防堵技术的切入点,加强免耕播种机防堵技术与作业工艺措施有机结合,加强作物残茬的几何特性和机械特性的基础研究,并降低防堵装置功率消耗和转速,提高定向抛撒能力和秸秆覆盖量适应性以及具有安全性能好和作业粉尘低等方面研究,同时加强利用高速摄影和虚拟仪器等现代先进测试仪器与技术开展秸秆抛撒运动规律研究,以探讨改善防堵性能的途径,提高免耕播种机播种质量和生产效率,加快旱地农业保护性耕作技术的推广应用. 相似文献
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Stuart J. SmythMichael Gusta Kenneth BelcherPeter W.B. Phillips David Castle 《Agricultural Systems》2011,104(5):403-410
The commercial production of herbicide tolerant (HT) canola began in Western Canada in 1997. With more than a decade of use, the actual farm-level environmental impact of HT canola can be evaluated. This article reports on a spring 2007 survey of nearly 600 canola farmers in the three prairie provinces of Western Canada. Producers were asked about their crop production experiences for 2005 and 2006 and expected crop planting for 2007. A reduction in the total number of chemical applications over the 3-year period was reported, resulting in a decrease of herbicide active ingredient being applied to farmland in Western Canada of nearly 1.3 million kg annually. Fewer tillage passes over the survey period were reported, improving moisture conservation, decreasing soil erosion and contributing to carbon sequestration in annual cropland. An estimated 1 million tonnes of carbon is either sequestered or no longer released under land management facilitated by HT canola production, as compared to 1995. The value of this carbon off-set is estimated to be C$5 million. Comparisons with similar studies and against non-adoption of HT canola can guide future decisions about HT canola adoption. 相似文献
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