可变剪接的表观遗传学调控机制及其在脂肪代谢中的作用研究进展

可变剪接是指从1个mRNA前体中通过不同的剪接方式产生不同的mRNA剪接异构体,并使得最终的蛋白产物表现出不同或者相互拮抗的功能和结构特性的过程.基因通过可变剪接在组织发育和疾病中起着至关重要的作用,是高等真核生物蛋白质多样性的主要来源之一.剪接过程受多种因素调控,其中表观遗传学现象是可变剪接过程中重要的影响因素,多项...     

浅谈水产健康养殖监管

为促进我省水产养殖持续健康发展,增强水产品质量安全意识,形成从源头到餐桌完整的水产品管理链条,切实保障水产品质量安全。2010年一2012年通过对我省沿黄地区网箱养殖场的监管,主要采取网箱标准化养殖技术、把好三关、建立五项制度、落实六项措施的监管方法,更进一步提高水产品质量安全监督管理体系。     

未来转基因作物的环境风险分析

 下一代转基因(GM)作物中新基因的不断增加和基因叠加,以及用GM作物作为生物反应器生产药物和工业用化合物,使GM作物的环境风险评价更加复杂和困难。讨论了存在的问题、未来监管政策和应当加强的相关研究领域。     

营养盐和光照对浮游植物群落结构的影响

2006年4月在沙埕港湾口处网箱养殖区,研究营养盐和光照对浮游植物类群及其优势种生长的影响。结果表明,微、小型浮游植物在100%自然光强下生长最快,微微型浮游植物在50%自然光强下生长最快。在各形态无机氮（N）、磷（P）营养盐存在的情况下,浮游植物会首先利用氨氮（NH4-N）,但培养后期NH4-N加富组的浮游植物丰度低于亚硝酸盐（NO2-N）加富组和硝酸盐（NO3-N）加富组。营养盐加富在短期内引起浮游植物数量的快速增加,当营养盐浓度达到一定水平后对浮游植物的生长不利,其抑制作用随浮游植物种类而异;随着营养盐消耗,浮游植物的数量和多样性均下降。微、小型浮游植物丰度与NO3-N、N/P呈显著相关,相关系数分别为-0.625、0.521;微微型浮游植物丰度与磷酸盐（PO4-P）呈显著相关,相关系数为0.530。     

Change of Th17/Treg in rat brain with acute ischemic stroke

AIM:To investigate the changes of T helper 17 (Th17) cells/regulatory T (Treg) cells in the brain of rats with acute ischemic stroke. METHODS:Acute middle cerebral artery occlusion (MCAO) model was established by thread embolization in SD rats, and sham operation was used as control. The infarct volume of the rats in each group was observed by TTC staining on day 3 after MCAO. The levels of interleukin-17A (IL-17A) and IL-10 in the brain tissues were measured by ELISA. RT-qPCR was used to detect the mRNA levels of IL-17, IL-10, Foxp3 and RORγt. The proportion of Th17 cells and Treg cells was measured by flow cytometry analysis. RESULTS:Compared with sham operation group, the protein level of IL-17A in MCAO group was increased (P<0.05), and the protein level of IL-10 was decreased (P<0.05). The mRNA expression of RORγt and IL-17 was increased (P<0.05), and the mRNA levels of Foxp3 and IL-10 were decreased (P<0.05). The proportion of Th17 cells was increased (P<0.05), while the proportion of Treg cells was decreased (P<0.05), and the Th17/Treg ratio was thus increased (P<0.05). CONCLUSION:The increase in Th17 cells and the decrease in Treg cells in the brain tissues of acute ischemic rats indicate that the immuno-inflammatory response is activated after cerebral infarction, and the balance of T helper 17/Treg is broken.     

Pathogenesis,prevention and treatment of COVID-19 based on Th17/Treg immune imbalance

The extremely severe epidemic situation of coronavirus disease 2019 （COVID-19） outbreak around the world with high infectiousness and rapid spread has become a public health emergency of international concern. The disease is caused by severe acute respiratory syndrome coronavirus 2 （SARS-CoV-2）, and cytokine storm is an important pathological manifestation. Related studies have shown that cytokine storm and dysregulation of host immune responses characterized by lymphopenia are important mechanisms for the pathogenesis of severe COVID-19. The immune response disorder of COVID-19 is closely related to T helper 17 cell/regulatory T cell （Th17/Treg） immune imbalance. SARS-CoV-2 infection leads to excessive activation of lung immune cells, forming a cytokine storm dominated by interleukin-6 （IL-6）. Then, the Th17/Treg immune balance is broken, forming a vicious circle, which eventually promotes the rapid aggravation of the disease. Finally, COVID-19 progresses into acute respiratory distress syndrome, and even respiratory failure until death. Therefore, it is more important to discuss the prevention and treatment of COVID-19 from the perspective of immune imbalance. On the view of treatment, before effective antiviral drugs and vaccines are successfully developed, we should pay attention to immune regulation for severe and critically ill patients. Treatments with inflammatory factor blockers, glucocorticoids, recovered plasma and traditional Chinese medicine have certain immunomodulatory effect. This article discusses the pathogenesis of COVID-19 based on Th17/Treg immune imbalance, and elaborates on immunomodulatory therapy, aiming to provide reference for the prevention and treatment of COVID-19 and drug development.     

A SURVEY STATION OF MEASURING DAYLIGHT AND SOLAR IRRADIANCE IN CHONGQING

This paper intreduces a survey station of measuring daylight and solar irradiancein Chongqing.It has been set up for responding to the International Dayllght Year.From the ways ofmeasuring place,instruments,data and results,etc. the station has run successively in two years tomeasure eleven data about irradiance and illumination etc. by automatic measuring systems.A vastamoun t of scientific data is collected and these firstha nd reliable in formations are provided to day-light climates research in Chongqing.Both data results and measuring means corne up to advancedworld standards.Modern science and technology are successfully applled to daylight measuring andresearch.     

大穗型和多穗型冬小麦分蘖成穗的调控因子研究进展（英文）

为了研究大穗型和多穗型冬小麦分蘖成穗调控因子及其调节机理,实现产量提升,本文归纳了遗传因素、群体环境因素、内源激素等方面对不同类型品种分蘖成穗特性影响的研究进展。认为,以后研究应侧重于多种分蘖调控因子的影响机制及因子间的关系,通过研究分蘖过程中内源激素含量、激素间平衡及基因表达、调控与小麦分蘖发生关系的研究,以期为小麦高产栽培研究提供理论依据和技术支持。     

中国农产品批发市场食品安全监管研究

随着生活水平的不断提高,人们越来越关注舌尖上的食品质量安全问题。尤其是近年来食品安全事故频发,使得人们对食品安全的关注度越来越强,对食品安全的监管也提出了新的要求。文章对中国的食品安全监管研究进行了梳理,围绕食品安全监管模式、食品安全监管制度的缺陷与完善以及流通环节食品安全监管制度等方面进行了评述,并提出了中国农产品批发市场食品安全监管的未来研究趋势。     

稻飞虱自然种群扑灯行为的初步观察

白背稻虱自然种群扑灯日照阈限为0.91x,其典型的扑灯活动是一个扑灯量呈型的节律性过程。这种扑灯节律是其种群离株起飞节律的一个局部反映。 33米和1.3米两个高度的对照灯诱试验表明,前者灯下稻飞虱诱集量通常大大高于后者灯下诱量。表明稻飞虱种群存在趋光延迟现象,即夜间离株后首先表现强烈的升空飞行习性,在经历一定时间和距离的飞行活动后趋光表现迅速增强。