Transplantation of adipose derived mesenchymal stem cells for acute thoracolumbar disc disease with no deep pain perception in dogs

Thirty-four dogs with no deep pain perception due to acute thoracolumbar intervertebral disc disease underwent decompression surgery within 1 week of diagnosis. All dogs underwent hemilaminectomy. Adipose derived mesenchymal stem cells (AD-MSCs) were transplanted into the injured spinal cord parenchyma for the AD-MSCs transplant dogs. Long-term outcome was evaluated at the end of the follow-up period (> 6 months). AD-MSCs combination treatment showed better recovery outcomes compared to decompression surgery alone. These results indicate that this stem cell therapy is a potential therapeutic strategy to overcome the limitations of treatment for spinal cord injury in clinical medicine.     

基于特征的敏捷界面原型驱动开发过程框架

提出了一种基于特征的敏捷界面原型驱动开发过程框架(AIDD),给出了相应的形式化描述.基于该AIDD过程框架,结合项目实例,分析了如何应用该框架,实现从需求分析到有效设计的快速切换;将应用该过程的项目与其他规模相当的项目进行比对分析,结果表明:AIDD框架具备一定的理论基础并符合工程原则,解决了从需求到设计的快速切换问题,提高了以数据为中心的应用系统设计的质量和效率.     

A New Method for Measuring Bonding Shear Properties of Adhesives on Steel Substrates

Single-lap-joint adhesively bonded metal specimen which is the national standard experimental method in use has an extremely non-uniform distribution of shear stresses along the joint, and tensile stress concentration of high values is produced on the steel substrate interfaces. Therefore the test result, which is not the real bonding shear strength between adhesive and steel substrates, can only be used as a test index for qualities of adhesives not the strength criterion for load is capacity evaluation. The combined bonding disc specimen is adopted for measuring bonding shear properties of adhesive on steel substrates, has a very uniform distribution of shear stresses in adhesive and along the bonding surfaces of steel substrates, of which the uniform coefficient is greater than 0.97. Furthermore, when adhesive joint is treated as an arc and steel substrates are chamfered at both ends of the joint, tensile stresses on the bonding surfaces can be reduced to less than 20 MPa which can hardly cause tensile failure. Thus, the results of combined bonding disc specimens can actually represent the real bonding shear strength or bonding shear-compression strength between adhesive and steel substrates, which can be used as strength criterion for load capacity evaluation of bonding members.     

人参切片机设计研究

介绍了人参切片机的设计要求，探讨了人参切片机的技术关键。以满足切红参片的质量量要求为核心，对ＲＱＪ－Ⅱ型手摇人参切片机的结构设计做了阐述。该机采用切片厚度可调的盘刀切碎器入，入料口的尺寸、切片斜度可随音调整。     

CONTRAST ENHANCEMENT OF EXTRADURAL COMPRESSIVE MATERIAL ON MAGNETIC RESONANCE IMAGING

Gadolinium‐enhancement of compressive extradural material is detected occasionally with magnetic resonance (MR) imaging in dogs. Our goal was to characterize contrast enhancement of extradural compressive material associated with intervertebral disc herniation, and to evaluate the association between enhancement and histopathologic findings and the onset of clinical signs. Ninety‐three dogs with a total of 99 lesions diagnosed as intervertebral disc herniation on MR imaging were assessed. Images were evaluated for lesion location, type of herniation, degree of compression, intramedullary T2‐weighted (T2W) intensities, and contrast enhancement. In 23 dogs, surgically removed compressive material was evaluated histopathologically for hemorrhage, inflammation, neovascularization, fibroplasia, fibrosis, mineralization, necrosis, and chronicity. Contrast enhancement of extradural compressive material, meninges, and both the compressive materials and meninges was present in 51.5%, 39.4%, and 17.2% of lesions, respectively. Extradural enhancement occurred more frequently in extrusions than protrusions (P=0.001). Meningeal enhancement and more severe neurologic deficits were significantly associated with a shorter duration of clinical signs (P=0.04 and 0.01, respectively). Intramedullary T2W hyperintensities, present with 44.4% of lesions, were associated with more severe neurologic deficits (P=0.001). Lesions with extradural enhancement were more often considered subacute to chronic in duration and more frequently associated with hemorrhage compared with nonenhancing material; however, no statistically significant association was established between contrast enhancement and histopathologic findings. Contrast enhancement of extradural compressive material and the meninges was found to be common with intervertebral disc herniation, and should not be interpreted as a specific sign of a mass lesion such as neoplasia.     

圆盘入渗仪法测定不同利用方式土壤渗透性试验研究

介绍了一种田间定量测定土壤渗透性的新方法——圆盘入渗仪法。应用该法和双环法对黄土丘陵区土壤不同利用方式(果园、农地、灌木、草地、林地)下的土壤渗透性进行了对比研究，并对比分析了该方法的优缺点。结果表明：在该试验条件下，不同利用方式下土壤的孔性及渗透性有明显差别。土壤有效孔径以灌木地最大，为农地的5.7倍，果园的3.5倍；其次为林地和草地，为农地的4倍多，果园的2.5倍多。果园的最初入渗率最大，是林地的3倍，草地的5倍。稳定入渗率大小顺序为：果园>农地>灌木>草地>林地。灌木地的导水率是农地的1.5倍，是林地的3倍多；草地和果园的土壤导水率是农地的1.2倍，是林地的2.8倍。两种方法测定的入渗率结果具有显著的线性相关性。说明圆盘入渗仪法适合于黄土丘陵区各种利用类型土壤的入渗测定。     

独立圆盘耙单体排列参数对秸秆堵塞影响研究

为对秸秆覆盖混埋还田耕整地技术模式进行深入研究,需要研发配套圆盘耙联合整地机具,机具研发过程中首先要解决受秸秆影响的堵塞问题.通过进行影响因素的单因素试验和3因素3水平正交试验,探索独立连接圆盘耙单体排列参数对秸秆堵塞问题的影响规律.通过单因素试验确定对应机具通过性评分为3分的三个因素临界值:耙片间距为275 mm,横...     

喷嘴结构对网衣清洗装备水下空化特性的影响

针对我国深远海大型网箱养殖网衣清洗装备缺乏的难题,基于高压射流空化原理,研制了一种双体深水网箱网衣清洗装备。采用数学建模及物理试验方法,建立了清洗装备关键部件的水动力特性分析方程,开展清洗装备水下清洗试验,探究了不同工况下的喷嘴孔径、喷嘴与转盘夹角 (喷嘴轴线与分流转盘盘面所呈角度)、靶距对清洗装备污损生物清洁率的影响。结果表明：网衣挂板污损生物去除率受靶距、喷嘴孔径、喷嘴和转盘夹角等多因素影响,试验参数范围内网衣清洗装备污损生物去除率为30.26%~72.55%;试验范围内喷嘴孔径为1.0 mm,喷嘴与转盘夹角为60°,靶距为0 cm时网衣挂板污损生物去除率最大,靶距对网衣挂板污损生物去除率的影响最为显著。贝类污损生物在清洗装备空化射流冲击作用下主要以壳体破碎形式脱落,网面主要残留物为具有较强吸附力的软质足丝盘。研究结果进一步优化了水下清洗装备系统的参数配置,为网衣清洗装备的设计提供了理论支撑。

     

COMPARISON BETWEEN COMPUTED TOMOGRAPHY,FLUOROSCOPY, AND ULTRASONOGRAPHY FOR GUIDING PERCUTANEOUS INJECTION OF THE CANINE INTERVERTEBRAL DISC

A minimally invasive method for delivering injectable therapeutic agents would be desirable for the treatment of intervertebral disc disease in dogs. The purpose of this study was to compare computed tomography (CT), ultrasonography (US), and fluoroscopy modalities for guiding percutaneous injection into canine intervertebral discs. Intervertebral discs of 14 dog cadavers were injected with a gelified ethanol therapeutic agent. Successful injectate placement and injectate leakage were determined based on necropsy inspection of discs. Injection into the nucleus pulposus was successful in 55 of 78 (71%) of all injected discs. Injections guided using CT and fluoroscopy were significantly more successful than US‐guided injections. Odds of successful injection without leakage were greater for CT vs. US (P = 0.0026) but there was no significant difference between CT and fluoroscopy (P = 0.0620). Injection success rates did not differ among vertebral sites or dog cadavers of varying weights. Forty‐nine (63%) of injection sites had injectate leakage outside the disc and 10 of these involved structures within the vertebral canal. The highest rate of injection success with the least amount of leakage was achieved with CT guidance. Findings indicated that CT, fluoroscopy, and US are feasible modalities for guiding percutaneous injection of a gelified ethanol therapeutic agent into the canine intervertebral disc, with moderate to high success rates for different regions of the spine. However, a moderately high rate of injectate leakage occurred outside of the disc and this should be taken into consideration for future safety and efficacy studies.     

KM-650型拖拉机离合器设计与研究

介绍了KM-650型拖拉机离合器的设计理论并进行了结构分析:增加一套副离合器操纵系统,节省驾驶员的体力;开有梯形槽的碟形弹簧在制造过程中易产生应力集中,把梯形槽改为弧形槽使离合器寿命大有提高.