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Abigail L. Fowden Juanita K. JellymanOrlando A. Valenzuela DVM MSc Alison J. Forhead PhD 《Journal of Equine Veterinary Science》2013
Human epidemiological observations and studies of experimental animals have shown that low birth weight is associated with adult phenotypes characterized by abnormalities in cardiovascular, metabolic, and endocrine function. In human populations, these changes can lead to overt degenerative diseases such as hypertension and type 2 diabetes. Because fetal growth depends primarily on the nutrient supply, the associations between birth weight and adult phenotype have been linked to poor nutrition in utero. The fetal supply of nutrients and oxygen depends on both the availability of these substances in the mother and the functional capacity of the placenta to supply them to the fetus. This review takes a comparative approach to examining the nutritional programming of adult physiological phenotype in mammals with emphasis on the horse where possible. It considers the role of maternal nutritional state and placental function in these processes and discusses the cellular and molecular mechanisms operating in utero that are responsible for the epigenetic regulation of phenotypical diversity. 相似文献
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The long-term effects of gestational immaturity in the premature (defined as < 320 days gestation) and dysmature (normal term but showing some signs of prematurity) foal have not been thoroughly investigated. Studies have reported that a high percentage of gestationally immature foals with related orthopedic issues such as incomplete ossification may fail to fulfill their intended athletic purpose, particularly in Thoroughbred racing. In humans, premature birth is associated with shorter stature at maturity and variations in anatomical ratios, linked to alterations in metabolism and timing of physeal closure in the long bones. We hypothesized that gestational immaturity in horses might similarly be associated with reduced height and different anatomical ratios at maturity. In this preliminary study, the skeletal ratios of horses with a history of gestational immaturity, identified through veterinary and breeder records, were compared with those of unaffected, closely related horses (i.e., sire, dam, sibling). External measurements were taken from conformation photographs of cases (n = 19) and related horses (n = 28), and these were then combined into indices to evaluate and compare metric properties of conformation. A principal component analysis showed that the first two principal components account for 43.8% of the total conformational variation of the horses’ external features, separating horses with a rectangular conformation (body length > height at the withers), from those that are more square (body length = height at the withers). Varimax rotation of PC1 and analysis of different gestational groups showed a significant effect of gestational immaturity (P = .001), with the premature group being more affected than the dysmature group (P = .009, P = .012). Mean values for the four dominant indices showed that these groups have significantly lower distal limb to body length relationships than controls. The observed differences suggest that gestational immaturity may affect anatomical ratios at maturity, which, in combination with orthopedic issues arising from incomplete ossification, may have a further impact on long-term athletic potential. 相似文献
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脂肪的过度沉积常伴随着胰岛素抵抗、Ⅱ型糖尿病等代谢病症,既危害人类健康,带来经济负担,也会在农业生产中影响畜牧产品的质量。脂肪的沉积,始于胚胎期脂肪组织的发育,是一系列程序化作用的结果。脂肪沉积受多方因素影响,营养干预可以通过胚胎环境中的糖皮质激素浓度、线粒体功能、表观遗传、食欲中枢发育等方面影响胚胎脂肪沉积程序化。论文阐述了动物出生前后营养状况对脂肪沉积程序化的作用,对脂肪沉积的机制进行了初步探讨,并介绍了精氨酸营养在脂肪沉积中的应用。饮食中添加精氨酸为治疗脂肪过度沉积,提高畜牧生产水平,改善人类生活质量,开拓了新的思路。 相似文献
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Nutritional management of animals during pregnancy can affect glucose and insulin dynamics in the resulting offspring through influences on fetal development. Additionally, high starch feeding in mature horses is associated with reduced insulin sensitivity and an increased risk for diseases such as obesity and laminitis. However, no study has yet evaluated the effect of feeding a high starch diet to pregnant mares on glucose and insulin dynamics in their offspring. Twenty late-gestation mares maintained on pasture were provided two-thirds of digestible energy requirements from isocaloric, isonitrogenous low starch (LS, n = 10) or high starch (HS, n = 10) feed. Their foals were assessed with an insulin-modified frequently sampled intravenous glucose tolerance test at 5, 40, 80, and 160 d of age. Baseline glucose concentrations, insulin sensitivity, and insulin-independent glucose clearance in 5-d foals were all greater than values observed in mature horses and declined towards mature values as foals reached 160 d of age. Baseline glucose concentrations were all within normal range, but higher in foals born from HS mares through 80 d of age. Insulin sensitivity was not different between dietary groups until a trend for lower insulin sensitivity in HS foals emerged at 160 d of age. These data are the first to characterize decreasing insulin sensitivity and glucose tolerance in Thoroughbred foals from 5 to 160 d of age. This study also presents the first data examining glucose and insulin dynamics in developing foals in response to maternal high starch diet. 相似文献
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In this paper the optimal model of repaying debt combined with operational research and technology economics was presented. It is for solving the problem to increase the benefit of project in terms of planning to repay capital with interest. 相似文献
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Chen HuaZhou Jiaqi 《保鲜与加工》1990,(4):1-6
Based on the maximum flow principle about networks, a network flow approach to reliability evaluation in large scale netwerks ty mixing inereasing flow with decreasing flow is proposed in this paper.This approach gets the initial flow of each branch in a r.etwork associated with a state of the retwork by decreasing flows of some branches correlative to another state of the network.As a result, the number of flow compute required can be reduced enormously.The numerical example shows that the approach is powerful. The comparison of this approach with the minimal cutset one is also given in this paper. 相似文献
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For the inequality constrained nonlinear programming problem, the antnors propose a new lower order penalty function, which combines the classical l1 penalty function and the lower order exact penalty function introduced in thoy some papers, and then illustrate that it has the merits of the two penalty functions. In additional, we propose a solution method for solving the inequality constrained nonlinear programming problem and prove its global convergence. 相似文献
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针对机耕道场景下自动驾驶农机行驶的安全性、平稳性与规划实时性的实际需求,该研究提出了一种基于二次规划的局部路径规划方法。首先基于有限状态机构建农机机耕道行驶模式,其次采用横纵向解耦的方法,通过改进状态栅格法分别对农机速度行为和轨迹行为进行决策,随后利用二次规划方法生成满足多目标、多约束条件的农机轨迹和速度,得到最优路径,最后在多种行驶环境中进行仿真和实车试验,行驶参考速度为2 m/s。实车试验结果表明,在绕行静态障碍物场景中,规划轨迹的平均绝对曲率为0.021 m-1,最大绝对曲率为0.056 m-1,平均绝对横向误差为3.23 cm,最大绝对横向误差为8.69 cm,农机与障碍物外轮廓的距离大于0.76 m;在规避相向行驶、同向行驶和横穿机耕道的动态障碍物场景中,规划速度的平均绝对速度误差为0.08~0.12 m/s,绝对速度误差小于0.38 m/s,加速度变化范围为-0.38~0.44 m/s2。在规划周期为200 ms的仿真试验中,本文算法平均耗时48 ms,最大耗时75 ms,相比采用静态状态栅格法平均耗时减少38 ms,算法效率提升44%。研究结果可为机耕道场景下的农机局部路径规划提供技术支持。 相似文献