Dacarbazine as Single-Agent Therapy for Relapsed Lymphoma in Dogs

Background: Multidrug resistance is the most common cause of treatment failure in dogs with multicentric lymphoma. 5-(3,3-Dimethyl-1-triazeno)-imidazole-4-carboxamide (DTIC) is an atypical alkylator used as standard treatment in human Hodgkin's lymphoma, and has been effective in combination treatment to treat resistant lymphoma in dogs. However, no data are available on the use of DTIC as a single agent in the treatment of relapsed canine lymphoma.
Hypothesis: Single-agent DTIC is effective and safe in treating dogs with lymphoma that relapsed or failed to respond to previous chemotherapy.
Animals: Forty client-owned dogs with relapsed lymphoma.
Methods: Dogs were eligible for the retrospective study if they had a histologically or cytologically confirmed diagnosis of lymphoma and had relapsed. Dogs received DTIC (800–1,000 mg/m² every 2–3 weeks as a 4–5-hour IV infusion) and were evaluated for response rate and duration. Hematologic and gastrointestinal toxicity was assessed.
Results: The overall response rate for dogs being treated with DTIC was 35% (14 dogs) with a median progression-free interval of 43 days. Thirteen dogs had a partial response and 1 dog had a complete response. Stable disease was achieved in 3 dogs. Mild gastrointestinal toxicity was reported in 3 dogs posttreatment. Thrombocytopenia was the principal toxicity observed 7–14 days after the treatment. Treatments were delayed because of thrombocytopenia.
Conclusions: DTIC, when used alone, is effective in the treatment of dogs with relapsed lymphoma.     

组建校园无线局域网络的探索

通过无线网络进行教学的发展前途广阔,为了推动校园无线局域网络的建设,对组建无线局域网络的主要技术和设备进行了研究,探索了适合组建校园无线局域网的无线网络技术和设备,并根据实践经验介绍了校园局域网硬件安装完成后的设置细节。     

建立我国森林资源管理网络化信息系统的架构设计

从我国目前林业发展的实际状况出发 ,分析了建立我国森林资源信息系统应采用的网络设计模型 -紧缩核心设计 ,并对骨干网络结构、三级节点接入方式、IP分配和OSPF路由区域作出了合理的设计 ,从而构成了一个简洁、高效、稳定和可扩展的分级网络结构     

Carbon density and accumulation in woody species of tropical dry forest in India

We studied the carbon density and accumulation in trees at five sites in a tropical dry forest (TDF) to address the questions: how is the TDF structured in terms of tree and carbon density in different DBH (diameter at breast height) classes? What are the levels of carbon density and accumulation in the woody species of TDF? Is the vegetation carbon density evenly distributed across the forest? Does carbon stored in the soil reflect the pattern of aboveground vegetation carbon density? Which species in the forest have a high potential for carbon accumulation? The WSG among species ranged from 0.39 to 0.78 g cm⁻³. Our study indicated that most of the carbon resides in the old-growth (high DBH) trees; 88-97% carbon occurred in individuals ?19.1 cm DBH, and therefore extra care is required to protect such trees in the dry forest. Acacia catechu, Buchanania lanzan, Hardwickia binata, Shorea robusta and Terminalia tomentosa accounted for more than 10 t ha⁻¹ carbon density, warranting extra efforts for their protection. Species also differed in their capacity to accumulate carbon indicating variable suitability for afforestation. Annually, the forest accumulated 5.3 t-C ha⁻¹ yr⁻¹ on the most productive, wettest Hathinala site to 0.05 t-C ha⁻¹ yr⁻¹ on the least productive, driest Kotwa site. This study indicated a marked patchy distribution of carbon density (151 t-C ha⁻¹ on the Hathinala site to 15.6 t-C ha⁻¹ on the Kotwa site); the maximum value was more than nine times the minimum value. These findings suggest that there is a substantial scope to increase the carbon density and accumulation in this forest through management strategies focused on the protection, from deforestation and fire, of the high carbon density sites and the old-growth trees, and increasing the stocking density of the forest by planting species with high potential for carbon accumulation.     

不同加载方式SIP墙体的抗剪性能

以3种不同的单向加载方式对以木质OSB覆面的SIP墙体进行侧向加载实验,对比分析3种加载方式下SIP墙体的破坏形式及这3种加载方式对墙体抗剪性能参数的影响,结果表明:3种加载方式得到的墙体的抗剪性能指标有所差异,其中,采用ISO22452加载协议,即对墙体施加持续增加载荷的加载方式所得到的极限承载力最大、极限位移和延性系数居中,分别为46.06 kN、71.83 mm、3.31;采用ASTM E72-05加载时极限承载力居中、极限位移及延性系数最大,分别为:40.66 kN、76.97 mm、4.07。采用ASTM E564-06加载,即对墙体施加阶段载荷并使阶段目标载荷持续作用一段时间的方式,所得到的极限承载力、极限位移及延性系数最小,分别为37.73 kN、54.92 mm、2.91;3种加载方式对墙体破坏形式的影响不大。     

Coastal environment of the past millennium recorded by a coastal dune in Fujian,China

Coastal dune is a common aeolian geomorphology in a sandy coast,which records the evolution process of the aeolian landscape system and reflects the complex interaction among land surface,atmosphere and ocean.Coast is a sensitive area to global climate change.Restricted by chronology,most previous researches in China focused only on the cause of formation of coastal dunes.In recent years,the development of optically stimulated luminescence (OSL) dating provides a good method and acts as a carrier for coastal dunes to paleoclimate and paleoenvironmental studies.In this study,we selected an aeolian dune at the Anshan archaeological site,Fujian,China as the research object based on field observations.For determining their sedimentary stages and the primary influencing factors,we used the OSL dating method to construct a chronological framework for the aeolian dune.In addition,the sizes of grains were analyzed for identifying factors influencing the winter monsoon during the Medieval Warm Period (MWP) and the Little Ice Age (LIA) in this area.The results showed that the deposition of the aeolian dune was closely related to variations in the winter monsoon intensity.The changes of the winter monsoon were similar to the tendency of the East Asian winter monsoon,although there were several sub-fluctuations.From an overall perspective,the winter monsoon was strengthened during the MWP (1050–1300) .The results of a power spectrum analysis showed that the intensity of the East Asian winter monsoon is correlated with sunspot activity.     

能量平衡与QoS保障的无线传感器网络机会路由

针对无线传感器网络应用中存在大量不可靠通信链路,很难实现能效优化与QoS保障,提出一种能量平衡与QoS保障的机会路由协议EQGOR,并结合机会转发特征建立了传输效率、转发时延、转发能效与节点剩余能量模型提出了一种基于多目标粒子群的自适应转发集优化算法,该算法兼顾能量与QoS需求,能实现QoS保障并最大化网络生存时间.仿真实验表明,相比机会路由GOR与传统的QoS多路径路由QuESt,本文提出的EQGOR(Energy balanced and QoS guaranteed Geographic Opportunistic Routing)具有更优的QoS与能量效率.     

Sampling plans,selective insecticides and sustainability: the case for IPM as ‘informed pest management’

Integrated Pest Management (IPM) is considered the central paradigm of insect pest management and is often characterized as a comprehensive use of multiple control tactics to reduce pest status while minimizing economic and environmental costs. As the principal precursor of IPM, the integrated control concept formulated the economic theory behind pest management decisions and specified an applied methodology for carrying out pest control. Sampling, economic thresholds and selective insecticides were three of the critical elements of that methodology and are now considered indispensable to the goals of IPM. We examine each of these elements in the context of contemporaneous information as well as accumulated experience and knowledge required for their skillful implementation in an IPM program. We conclude that while IPM is principally about integrating control tactics into an effective and sustainable approach to pest control, this overarching goal can only be achieved through well‐trained practitioners, knowledgeable of the tenets conceived in the integrated control concept that ultimately yield informed pest management. Copyright © 2009 Society of Chemical Industry     

Critical Evaluation of Whole-Body Cryostimulation Protocol in Race Horses

Cold therapy is commonly used to relieve pain and inflammation and to aid in muscle recovery after exercise in human medicine. A number of applications have also been observed in veterinary practice. In this article, a critical evaluation of equine protocol applied with a new commercial concept of equine whole-body cryostimulation (WBC) was made. With this new concept of WBC, the protocol usually utilized for relieving pain and discomfort in humans has been extended to horses. The investigations described herein focus on the reduction of horse skin temperature when applying human WBC protocols. Based on infrared thermography measurements, results show that exposing a horse for 3 minutes to a temperature of −140°C, which are conventional parameters used for humans, does not induce sufficient skin thermal gradients in horses. Consequently, beneficial cold reflexes such as vasomotor, neuroconduction, and biochemical reactions cannot be triggered. Further investigations should therefore be carried out to design an adequate protocol specifically aimed at horses.     

Smart Phone Assisted City-scale Wireless Sensor Network Deployment for Transportation System Monitoring

<正>1.INTRODUCTION Ensuring transportation network security is one Of the most daunting challenges confronting homeland security agencies today.Significant research has been dedicated.To model and analyze the vulnerability of transportation systems,while notably fewer studies propose specific strategies for deploying defensive technologies to safeguard these systems.