Complexing the Marine Sesquiterpene Euplotin C by Means of Cyclodextrin-Based Nanosponges: A Preliminary Investigation

Euplotin C is a sesquiterpene of marine origin endowed with significant anti-microbial and anti-tumor properties. Despite the promising functional profile, its progress as a novel drug candidate has failed so far, due to its scarce solubility and poor stability in aqueous media, such as biological fluids. Therefore, overcoming these limits is an intriguing challenge for the scientific community. In this work, we synthesized β-cyclodextrin-based nanosponges and investigated their use as colloidal carriers for stably complex euplotin C. Results obtained proved the ability of the carrier to include the natural compound, showing remarkable values of both loading efficiency and capacity. Moreover, it also allowed us to preserve the chemical structure of the loaded compound, which was recovered unaltered once extracted from the complex. Therefore, the use of β-cyclodextrin-based nanosponges represents a viable option to vehiculate euplotin C, thus opening up its possible use as pharmacologically active compound.     

Physicochemical,Structural and Antioxidant Properties of Collagens from the Swim Bladder of Four Fish Species

This study aimed to isolate and characterize pepsin-solubilized collagen (PSC) from marine and freshwater fish swim bladders. The physicochemical properties, protein pattern, amino acid composition, structure, thermal denaturation temperature, and antioxidant activity of PSC from four different swim bladder sources were investigated and compared. The results demonstrated that the four types of collagen extracted were all type I collagen. The yield of PSC extracted from grass carp (GCSB-PSC), bighead carp (BCSB-PSC), grouper (GSB-PSC), and monkfish swim bladders (MSB-PSC) were 38.98, 27.97, 18.16, and 10.35%, respectively. Compared to the other three PSCs, BCSB-PSC has the highest thermal denaturation temperature (38.60 °C). Based on FTIR spectroscopy and circular dichroism (CD) analysis, the extracted PSCs retained the triple helix and secondary structure well. Antioxidant studies showed that in the swim bladders of four species the swim bladder PSC could scavenge DPPH and ABTS radicals. Overall, swim bladders from marine and freshwater fish can be utilized as raw materials for collagen extraction, and the extracted collagen has potential commercial applications.     

ICP-AES测定山药与红薯中的微量元素

目的分析东北不同地区细毛长山药的营养品质和药理活性成分。方法以黑龙江齐齐哈尔、吉林长春和辽宁沈阳的细毛长山药为材料,采用灼烧法和常压干燥法测定其灰分和水分含量;电感耦合等离子体原子发射光谱法测定微量元素含量;根据国家标准测定营养物质含量;用高效液相色谱法测定尿囊素的含量,分光光度法测定薯蓣皂苷及总多酚的含量;用水提醇沉工艺进行活性多糖的提取,并计算含量。结果沈阳产山药的水分和灰分含量最低,与长春和齐齐哈尔产山药相比差异显著(P<0.05);沈阳产山药的营养品质最好,药理活性成分含量也最高;其中,沈阳和长春产山药的可溶性总糖和蛋白质含量的平均值均显著高于齐齐哈尔(P<0.05),沈阳产山药的总氨基酸含量平均值也显著高于齐齐哈尔(P<0.05),但与长春相比差异不显著;淀粉和粗脂肪含量均表现为沈阳>长春>齐齐哈尔,但差异均不显著;沈阳产山药的活性多糖、尿囊素、总多酚和薯蓣皂苷含量显著高于长春和齐齐哈尔(P<0.05);微量元素中Fe元素含量在3个地区的差异不显著;沈阳产山药的Mn元素平均含量显著高于齐齐哈尔和长春的平均含量(P<0.05),沈阳和长春产山药的Pb含量显著高于齐齐哈尔(P<0.05)。结论东北这3个地区中沈阳产山药的营养品质和药用保健功能最高,可为东北高寒地区山药的开发利用提供理论参考。     

孑遗植物长苞铁杉 (Tsuga longibracteata) 分布格局对未来气候变化的响应

研究绢毛相思的染色体数目及核型。绢毛相思体细胞染色体数目是2n=4x=52,为四倍体。其核型组成为K(2n)=52=44m+4sm+4st;染色体长度均在2μm以下,为小染色体。     

《图书馆学研究》学术影响力分析

根据文献计量学方法,利用＂中国知识基础设施工程＂（CNKI）资源,从载文量、下载量、各年被引量、影响因子等指标对《图书馆学研究》进行了统计分析,研究了其在图书情报领域中的地位和学术影响力。     

我国情报学研究生培养领域热点——基于期刊论文关键词的统计分析

本研究采用文献计量学的关键词分析法,万方数据库中检索到的896篇与情报学研究生培养相关的学术论文进行关键词分析,分析出关键词频次和高频关键词的分布特征,并作关键词共词分析,探讨我国情报学研究培养领域的热点和存在的问题,对未来情报学研究生培养进行一个新角度的探索。     

基于反馈回归法的用电量预测模型研究

多元线性回归法是用电量预测中常用的一种方法,带反馈的多元线性回归法是一种改进的回归方法,具有更高的精度.本文在此基础上进行了多次反馈,即利用带多次反馈的多元线性回归法,结合SPSS软件进行统计分析,并以陕西省用电量为例探究分析多次反馈的多元线性回归法在用电量预测中的应用,从而得到更精准的用电量预测模型.最后以四川省的用电量数据对模型进行了验证,体现出了该模型的优越之处.     

Inheritance of genes coding for gliadin proteins and glume colour introgressed into Triticum aestivum from a synthetic wheat

A synthetic hexaploid, Triticum timofeevii×T. tauschii, was used to transfer disease resistance genes to the commercial cultivar Saratovskaya 29 (S29) by backcrossing. After five backcrosses the resulting derivatives still showed some traits of the synthetic, namely brown spike glumes and several gliadin components. Genetic analysis showed that the derived forms had inherited the Gli-D1 allele of the synthetic, which was found to be tightly linked to a gene for glume colour. Recombination percentages between these genes was estimated to be 2.5 ± 1.7%. The development of the derivatives was also accompanied by a rearrangement within the Gli-B1 locus, resulting in the formation of a new variant of the allele in S29.     

水稻秧苗素质的模糊聚类分析及综合评判

通过模糊聚类分要将水稻秧苗分为四类,对各类秧苗进行了指标量化和综合评判,从而克服了以往对 秧苗素质判断的主观臆断性和盲目性,有利于对秧田进行科学管理。