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Antonella Leone Raffaella Marina Lecci Miriana Durante Stefano Piraino 《Marine drugs》2013,11(5):1728-1762
On a global scale, jellyfish populations in coastal marine ecosystems exhibit increasing trends of abundance. High-density outbreaks may directly or indirectly affect human economical and recreational activities, as well as public health. As the interest in biology of marine jellyfish grows, a number of jellyfish metabolites with healthy potential, such as anticancer or antioxidant activities, is increasingly reported. In this study, the Mediterranean “fried egg jellyfish” Cotylorhiza tuberculata (Macri, 1778) has been targeted in the search forputative valuable bioactive compounds. A medusa extract was obtained, fractionated, characterized by HPLC, GC-MS and SDS-PAGE and assayed for its biological activity on breast cancer cells (MCF-7) and human epidermal keratinocytes (HEKa). The composition of the jellyfish extract included photosynthetic pigments, valuable ω-3 and ω-6 fatty acids, and polypeptides derived either from jellyfish tissues and their algal symbionts. Extract fractions showed antioxidant activity and the ability to affect cell viability and intercellular communication mediated by gap junctions (GJIC) differentially in MCF-7and HEKa cells. A significantly higher cytotoxicity and GJIC enhancement in MCF-7 compared to HEKa cells was recorded. A putative action mechanism for the anticancer bioactivity through the modulation of GJIC has been hypothesized and its nutraceutical and pharmaceutical potential was discussed. 相似文献
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Merryn McKinnon Mizaan Ahmad Meg Bongers Rory Chevalier Isabel Telfer Clare Van Dorssen 《Human Dimensions of Wildlife》2018,23(1):90-99
Culling kangaroos, Australia’s most abundant marsupial, is a controversial practice in the Australian Capital Territory (ACT). The ACT government introduced a kangaroo management plan in response to the growing kangaroo population causing damage in grassland ecosystems. Although some groups (e.g., local government, some researchers) support implementation of this plan, critics claim it is inhumane and lacks concrete evidence. To examine media portrayal of this debate, this study conducted a content analysis of newspaper coverage between 2006 and 2016. Although ACT newspapers were impartial in their presentation of the debate, sources that previous studies found were typically considered trustworthy to speak on the scientific validity of the program were found to have conflicting messages and be less represented in the media. Thus, future research should explore if the messenger is more important than the message in determining influences on public perceptions about the use of lethal control. 相似文献
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奶牛体温是衡量奶牛健康状况的重要参数,定时采集奶牛体温对于判断奶牛的健康状况有着重要意义。人们对于数据传输大多采用有线方式,但牛舍环境不便于铺设线缆进行数据传输。为此,本系统利用收发芯片NRF24E1进行设计,实现了奶牛体温数据采集系统与上位机进行无线通信,满足了对奶牛体温数据实时监测的要求,提高了对奶牛体温数据采集的自动性和高效性。通过芯片的选型以及芯片外围电路的改进优化了硬件电路,并且设计了有效的通信协议,防止传输的数据信号产生畸变并具有自动剔除错误信号的能力。该系统对多头奶牛的体温进行了测量,试验表明,本系统具有较高的实用性和可靠性,成本低功耗低,具有良好的应用前景。 相似文献
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