浅谈人工挖孔桩的施工工艺及特殊问题的处理

本文主要论述了人工挖孔桩的施工工艺,并结合实际经验阐述了施工过程中遇到特殊问题的处理方法.     

谈在俄罗斯投资建设MDF项目的相关建设条件

MDF项目在我国已进入快速发展的时期,而俄罗斯尚处在起步阶段.科学把握市场动态,利用有利的建设条件,将MDF移植至俄罗斯,是森工企业发展外向型林业产业,促进中俄林业经济技术合作的一个重要选项.     

浅谈混凝土的施工温度与裂缝

从理论和实践上对混凝土的施工温度与裂缝之间的关系进行了初步探讨,阐明了只要做好多种预防措施,混凝土的裂缝是完全可以避免的.     

浅谈住宅工程初装饰

为适应市场经济的发展、满足广大住户对住宅二次装饰的需要,对住宅工程进行初装饰已势在必行.本文探讨了住宅工程初装饰的具体做法和质量葆证措施.     

基本建设单位对工程建设项目的管理程序

工程建设项目的管理程序是基本建设单位进行项目管理的关键.本文从项目的前期准备、工程项目建设、工程项目验收三个阶段论述了基本建设单位对工程建设项目的管理程序.     

造价管理确定方法常见问题及对策

本文剖析了工程造价管理确定方法存在的问题,并提出了相应的解决策略。以期为我国建设工程造价确定方法的改革作出一定的贡献。     

浅谈CFG桩复合地基

CFG桩是一种新的加固地基方法。具有适用范围广、加固地基效果明显、综合利用粉煤灰和工业废渣等优点。经济效益和社会效益好,极有推广价值。     

The Inhibitors of CDK4/6 from a Library of Marine Compound Database: A Pharmacophore,ADMET, Molecular Docking and Molecular Dynamics Study

Background: CDK4/6 (Cyclin-dependent kinases 4/6) are the key promoters of cell cycle transition from G1 phase to S phase. Thus, selective inhibition of CDK4/6 is a promising cancer treatment. Methods: A total of 52,765 marine natural products were screened for CDK4/6. To screen out better natural compounds, pharmacophore models were first generated, then the absorption, distribution, metabolism, elimination, and toxicity (ADMET) were tested, followed by molecular docking. Finally, molecular dynamics simulation was carried out to verify the binding characteristics of the selected compounds. Results: Eighty-seven marine small molecules were screened based on the pharmacophore model. Then, compounds 41369 and 50843 were selected according to the ADMET and molecular docking score for further kinetic simulation evaluation. Finally, through molecular dynamics analysis, it was confirmed that compound 50843 maintained a stable conformation with the target protein, so it has the opportunity to become an inhibitor of CDK4/6. Conclusion: Through structure-based pharmacophore modeling, ADMET, the molecular docking method and molecular dynamics (MD) simulation, marine natural compound 50843 was proposed as a promising marine inhibitor of CDK4/6.     

关于混凝土结构裂缝产生原因和防治措施的探讨

混凝土结构裂缝会降低结构的整体稳定性和抗震性能。裂缝产生的原因有荷载作用、温度变化、混凝土干缩、钢筋锈蚀、地基不均匀沉降及施工操作不当等;裂缝的预防可从结构设计、结构施工两方面考虑;裂缝治理方法有表面修补法、内部修补法。     

混凝土结构设计中的后浇带设计

混凝土结构中经常遇到超长的问题,本文就混凝土结构超长的温度缝和沉降缝是否均可设后浇带解决的问题,阐述了自己的观点。