Influence of Diet Type and Pretreatment Fasting on the Disposition Kinetics of Albendazole in Sheep

The influence of the quality and quantity of diets on the disposition kinetics of albendazole were studied in sheep in two different experiments. The plasma concentration profiles of albendazole sulphoxide and albendazole sulphone were measured following intraruminal administration of albendazole at 5.0 mg/kg body weight in weaner sheep offered three different diets: 100% green Sorghum spp., 100% dry mature Cenchrus ciliaris hay and a 50:50 mix of these two diets. The peak plasma concentrations and the availability of the albendazole metabolites, as measured by the area under the concentration–time curve, were significantly higher (p<0.01) in the animals offered exclusively dry fodder compared to other diets. Changing the diet from dry to green fodder resulted in a significantly lower systemic availability of the drug metabolites. It is suggested that a decreased transit time of the digesta in the bowel on the green diet, with its high water content, limited the systemic availability of the drug by reducing the time available for gastrointestinal absorption.An experiment on the influence of different levels of pretreatment fasting on the pharmacokinetics of albendazole revealed significantly higher (p<0.05) plasma concentrations of the anthelmintically active sulphoxide metabolite from 12 h onwards following administration of the drug in animals subjected to 24 h of pretreatment fasting compared to other groups with pretreatment fasting of 8, 12 or 18 h. The area under the concentration–time curve and the minimum residence time of the drug metabolites were significantly greater (p<0.05) in animals that had been fasted for 24 h. It is suggested that fasting induces a decrease in the flow of digesta through the gastrointestinal tract of ruminants and prolongs the duration of dissolution of the drug, resulting in enhancement of the absorption of albendazole and of the systemic availability of its metabolites.     

虫草蝠蛾幼虫空间分布型的研究

应用对青海省内虫草蝠蛾幼虫２ 年的调查资料,通过对丛生指标Ｉ、聚块性指标Ｍ ／ Ｍ 、平均拥挤度Ｍ 、扩散指标Ｉδ、聚集系数Ｃ 和聚集度指标ＣＡ 的测定,阐明了虫草蝠蛾幼虫空间分布格局的基本成分为个体群;种群基本成分的分布格局为聚集分布,并符合负二项式理论分布型。     

柔毛野豌豆根瘤菌接种效果试验研究

对柔毛野豌豆进行了根瘤菌接种,使柔毛野豌豆的产草量提高了６０％－６９％,土壤多固氮３０ｋｇ／ｈｍ＾２,改良了土壤,增加了绿肥效果,为促进生态农业和生态畜牧业的有机结合开辟了新途径。     

绿色食品示范区区域布局

依据地区资源和地域优势,中国食品发展中心和蓟县人民政府联合创办了绿色食品天津翠屏湖示范区,示范区从总体上划分６大区,并就基地建设划分为“５区、２带、６大基地”     

中国名茶──信阳毛尖

信阳毛尖是我国传统名茶之一,也是河南省的著名土特产之一。对其生产历史、产地、品质特征、原料要求、炒制工艺、内含化学成分进行了全面介绍。     

积的压缩映象的某些不动点定理

在完备度量空间上研究了可换积的压缩映象,从而建立了若干不动点定理,证明了不动点存在性、唯一性。它们是参考文献「１」－「４」的主要结果的改进、统一和发展。     

无界区域中的Carleman不等式

利用单边Ｌａｐｌａｃｅ变换的Ｐａｌｅｙ－Ｗｉｅｎｅｒ定理证明了在上半平面Ｃａｒｌｅｍａｎ不等式也是成立的。     

基于生态系统服务功能的东江流域关键性生态空间识别

东江流域生态环境脆弱,水土流失现象频发,进行关键性生态空间识别对维护其生态环境安全和促进区域可持续发展有着极其重要的意义.该研究通过重要性-敏感性构建关键性生态空间识别评价体系,使用NPP(Net Primary Productivity)定量评价法、模型评价法,定量揭示其关键性生态空间的分布特征.结果表明:1)东江流...     

广州荔湾区大沙河滨水空间景观改造

随着广州城市的快速发展,作为岭南人居环境重要载体的城市河涌滨水空间,面临着往更生态、更优质的生活空间活化的挑战。广州市荔湾区大沙河滨水空间改造,以碧道建设为契机,突出“以人民为中心”的要求,紧扣时代性、地域性、普适性和经济性,制定系统的改造策略和方案,抓住地域特色的营建,因势利导优化空间结构,因地置景,以“绣花功夫”精准活化水岸空间,使大沙河成为独具荔湾特色的绿色新地标。     

Broodstock spawning and larviculture of whiting (Merlangius merlangus L.) reared in captivity

In recent years, an increasing interest in the farming of marine ‘white’ fish, such as cod, has been observed in the aquaculture industry. One species being considered for aquaculture development is whiting (Merlangius merlangus L.). With little data being available on the domestication of this species, our study aimed to characterize spawning behaviour and rhythmicity in captive broodstock and provide original data on egg incubation, embryonic development and larval rearing. The results observed through video recording showed that spawning mainly occurred at night with active courtship behaviour. Daily egg batches were collected from two separate spawning seasons, with an average fertilization success declining from 77% to 53%. Time to hatch was inversely related to the incubation temperature and occurred after 78 degree‐days (9 days at 8 °C), with emerging larvae ranging in size from 3.3 to 3.46 mm total length and hatch success ranging from 48.3% to 99.9%. In comparison with a clear water environment, a green water regime during the first days of larval rearing significantly improved larval growth and survival. These results are the first to describe spawning activity, early development and larval performances in whiting and are promising for the potential future development of whiting aquaculture.