新复方中药制剂(沙大净)对实验性雏鸡白痢的防治效果

对人工感染鸡白痢的雏鸡采用新复方中药制剂“沙大净”按高(0.50%)、中(0.25%)、低(0.10%)三个剂量进行防治,用痢特灵组、氯霉素组、感染不用药组、不感染不用药组作为对照。结果表明:“沙大净”高、中、低剂量组与痢特灵组、氯霉素组对雏鸡白痢均有较好的防治效果;与痢特灵、氯霉素组相比“沙大净”高、中剂量组效果显著(P<0.05);痢特灵组、氯霉素组、“沙大净”低剂量组三者疗效相近(P>0.05)。     

桑螵蛸药用历史与研究进展

桑螵蛸是我国中药史上知名的中药，其研究历史悠久，涉及本草学、炮制方法、分类学、生药学、化学组成、临床应用和药理学各个方面，主治肾阳不足、遗精、阳萎、早泄、白浊、赤白带下、小便频数、遗尿等症；现已开发出固天泉胶囊等剂型。本文对其研究历史与进展作一简要综述，并指出今后研究中亟待解决的问题。     

中草药治疗奶牛卵巢功能失调性不孕症及其对生殖内分泌的调控

应用中草药治疗奶牛卵巢功能失调性不孕症取得了显著疗效。在此基础上 ,通过测定山羊灌服中草药“复方仙阳汤”前后促性腺素释放激素 (GnRH)、促卵泡素 (FSH)、促黄体素 (LH)、孕酮 (P4 )及 17β 雌二醇 (17β E2 )等生殖激素的含量变化 ,证明中草药有调控山羊生殖内分泌的作用。试验小白鼠在服用复方仙阳汤及单味中药(肉苁蓉、补骨脂、仙灵脾浸液 )后 ,子宫角外径厚度和子宫卵巢重量均较对照组 (服用 0 9%生理盐水 )高 ,表明上述中草药具有促进子宫、卵巢发育 ,促进发情、排卵的功能。给小白鼠肌注 0 2 5mg/d醋酸氢化可的松 10d后可成功地建立肾阳虚动物模型 ,表明中草药含有雌激素类的活性物质     

催乳灵对奶牛产奶性能影响的试验研究

在日粮的配合精料中添加中草药添加剂—“催乳灵”, 用这些饲料饲喂泌乳牛, 研究其对荷斯坦泌乳牛产奶性能的影响。经过60天的饲养试验, 结果表明: 添加催乳灵的试验组与没加催乳灵的对照组相比, 试验组奶牛日产奶量平均提高了3 56kg, 乳脂率提高了0 17个百分点, 经济效益达2 04元/头日。     

Transplacental infection of a foal with Anaplasma phagocytophilum

This is the first report to document transplacental transmission of Anaplasma phagocytophillum in the horse. A 4-year-old late-term pregnant mare presented for a recent onset of pyrexia due to equine granulocytic anaplasmosis (EGA). She was hospitalised for treatment with oxytetracycline and monitoring of high-risk foaling due to significant thrombocytopenia. Parturition occurred overnight, and the foal was PCR positive for A. phagocytophilum at birth. The foal was slow to stand and nurse, with signs of neonatal encephalopathy and anaplasmosis (thrombocytopenia). Therapy with oxytetracycline resulted in complete clinical recovery of the mare and foal within 5 days. Congenital anaplasmosis should be considered in any foal delivered to a mare suffering from EGA during late-term pregnancy and guide appropriate antimicrobial therapy.     

中草药添加剂在肉仔鸡生产中的应用

中草药添加剂是以传统中兽医“医食同源”理论和动物生理需要为主导,借助现代化饲料生产加工理论技术制成的绿色环保型添加剂。合理使用中草药添加剂能够促进动物生长发育﹑调节免疫系统和新陈代谢﹑保障动物健康。本文拟在综述中草药添加剂的生理功能及在肉仔鸡生产中的作用,分析其在生产应用中的缺陷,为其在肉仔鸡生产中的应用提供参考。     

中草药饲料添加剂在鸡生产中的应用

本文对中草药特点、分类、作用及其在生产实践中的应用等进行综述,阐明中草药作为饲料添加剂在提高鸡生产性能、免疫性能及疾病防治等方面的应用现状,为替抗产品的研发提供理论依据,促进绿色畜牧业的发展。 [关键词] 中草药添加剂|鸡|功能     

Predicting likelihood of in vivo chemotherapy response in canine lymphoma using ex vivo drug sensitivity and immunophenotyping data in a machine learning model

We report a precision medicine platform that evaluates the probability of chemotherapy drug efficacy for canine lymphoma by combining ex vivo chemosensitivity and immunophenotyping assays with computational modelling. We isolated live cancer cells from fresh fine needle aspirates of affected lymph nodes and collected post‐treatment clinical responses in 261 canine lymphoma patients scheduled to receive at least 1 of 5 common chemotherapy agents (doxorubicin, vincristine, cyclophosphamide, lomustine and rabacfosadine). We used flow cytometry analysis for immunophenotyping and ex vivo chemosensitivity testing. For each drug, 70% of treated patients were randomly selected to train a random forest model to predict the probability of positive Veterinary Cooperative Oncology Group (VCOG) clinical response based on input variables including antigen expression profiles and treatment sensitivity readouts for each patient's cancer cells. The remaining 30% of patients were used to test model performance. Most models showed a test set ROC‐AUC > 0.65, and all models had overall ROC‐AUC > 0.95. Predicted response scores significantly distinguished (P < .001) positive responses from negative responses in B‐cell and T‐cell disease and newly diagnosed and relapsed patients. Patient groups with predicted response scores >50% showed a statistically significant reduction (log‐rank P < .05) in time to complete response when compared to the groups with scores <50%. The computational models developed in this study enabled the conversion of ex vivo cell‐based chemosensitivity assay results into a predicted probability of in vivo therapeutic efficacy, which may help improve treatment outcomes of individual canine lymphoma patients by providing predictive estimates of positive treatment response.     

水解酸化-两级曝气生物滤池处理

通过模型试验研究了水解酸化-两级曝气生物滤池处理中药废水的效果.试验结果表明,当水力负荷为0.570m3/（m2·h）、气水比为4︰1时,本工艺对于中药综合废水有较好的处理效果,出水平均COD、SS和色度分别为80mg/L、44mg/L和35倍,达到了《污水综合排放标准》（GB8978-1996）中的一级排放标准.整个工艺具有流程简单、维护方便、抗冲击负荷能力强、运行稳定等特点.     

DNA指纹图谱在中草药真伪性鉴定中的应用

中药的鉴定包括两个方面，一是中药材的真伪，二是质量的高低。我国中药材资源情况复杂，不能满足中医临床和栽培育种的需要，急需进行系统而有效的研究，DNA指纹图谱技术为中草药的真伪鉴定提供了技术保证。