异源抗体对接方法预测流感病毒血凝素B细胞构象表位

为了对异源抗体对接方法预测流感病毒血凝素B细胞构象表位的可行性进行分析,本研究基于蛋白质相互作用界面的形状互补理论,使用异源抗体(来自于抗原抗体复合物1G9M、1RVF、1TPX、1NCA、1A2Y)的晶体结构同流感病毒血凝素(A/Aichi/2/68(H3N2))的晶体结构进行刚性分子对接,通过计算B细胞表位的预测表面和实际表面C-α原子之间的RSMD以及表位氨基酸的准确率,分析用异源抗体探测出血凝素B细胞表位的可能性。结果表明,不同的异源抗体均可结合到A/Aichi/2/68(H3N2)的已知B细胞表位,最佳的对接构象与原晶体结构重叠后表位残基C-α原子的均方根偏差均小于0.6埃,表位氨基酸预测的准确性大于60%,说明异源抗体对接方法可以尝试用于B细胞构象表位的预测。     

Genomic prediction for meat and carcass traits in Nellore cattle using a Markov blanket algorithm

This study was carried out to evaluate the advantage of preselecting SNP markers using Markov blanket algorithm regarding the accuracy of genomic prediction for carcass and meat quality traits in Nellore cattle. This study considered 3675, 3680, 3660 and 524 records of rib eye area (REA), back fat thickness (BF), rump fat (RF), and Warner–Bratzler shear force (WBSF), respectively, from the Nellore Brazil Breeding Program. The animals have been genotyped using low-density SNP panel (30 k), and subsequently imputed for arrays with 777 k SNPs. Four Bayesian specifications of genomic regression models, namely Bayes A, Bayes B, Bayes Cπ and Bayesian Ridge Regression methods were compared in terms of prediction accuracy using a five folds cross-validation. Prediction accuracy for REA, BF and RF was all similar using the Bayesian Alphabet models, ranging from 0.75 to 0.95. For WBSF, the predictive ability was higher using Bayes B (0.47) than other methods (0.39 to 0.42). Although the prediction accuracies using Markov blanket of SNP markers were lower than those using all SNPs, for WBSF the relative gain was lower than 13%. With a subset of informative SNPs markers, identified using Markov blanket, probably, is possible to capture a large proportion of the genetic variance for WBSF. The development of low-density and customized arrays using Markov blanket might be cost-effective to perform a genomic selection for this trait, increasing the number of evaluated animals, improving the management decisions based on genomic information and applying genomic selection on a large scale.     

黑龙江省水稻单产增长潜力预测方法研究

水稻是黑龙江省的主要粮食作物。加入WTO后,水稻生产、贸易、进出口等方面都面临新的形势,同时水稻产量的稳定和增长对于国家粮食安全、人民生活水平提高以及农民奔小康都有着重要意义。因此,探讨了应用Peal曲线函数模型对黑龙江省水稻单产进行预测的方法。     

A Kind of Directing Operation Expert Systems Based on Self-adaptive Predictor

In the general directing-operation expert systems.the information of directingoperation is often shown after the subprocess has finished,The aim of the thesis is to enhance thefunction of directing-operation,and suggest that we add the self-tuning predictor in the expertsystems and use it to direct the present operation.We have shown the case oftemperature-predicting experiment made in the small wine distillatorv so that we can illustrate thatit is feasible to use the predictor to direct the operation.     

行星摆线针轮减速机构的动力学虚拟仿真

以UG、ADAMS等三维造型及运动学、动力学分析软件为平台，利用虚拟设计技术建立了行星摆线针轮减速机构的动力学虚拟样机模型。探讨了行星摆线针轮减速机物理约束机制的实现方法，建立了虚拟样机系统的力学模型，验证了样机的动态干涉情况，并对摆线针轮减速机构进行了动力学仿真分析，最后还进行了柱销与输出轴作用力的虚拟实验分析。仿真分析结果表明，提出的摆线针轮减速机虚拟样机建模正确，有较好的可靠性和实用价值。     

优化运行理论在泵站综合自动化系统中的应用

利用改进的神经元网络构建了泵站流量以及效率预测模型，并利用改进的遗传算法构建了泵站优化模型。将这两个模型应用到泵站综合自动化系统中，可以完成对泵站流量及效率的准确预测，并在此基础上实现泵站的优化运行。讨论了泵站优化运行理论在泵站综合自动化系统中应用的步骤和方法。     

螺旋离心式潜水排污泵叶轮的加工

对引进意大利技术生产的螺旋离心式水泵中的关键零件螺旋式叶轮的结构特点进行了分析，讨论了叶轮的加工工艺、夹具及工装设计对叶轮精度的影响，确定了螺旋式叶轮的加工工艺、校平衡的方法及加工中应注意的问题。     

Conversion to organic arable farming in The Netherlands: A dynamic linear programming analysis

Several studies show that organic farming is more profitable than conventional farming. However, in reality not many farmers convert to organic farming. Policy makers and farmers do not have clear insight into factors which hamper or stimulate the conversion to organic farming. The objective of this paper is to develop a dynamic linear programming model to analyse the effects of different limiting factors on the conversion process of farms over time. The model is developed for a typical arable farm in The Netherlands central clay region, and is based on two static liner programming models (conventional and organic). The objective of the model is to maximise the net present value over a 10-year planning horizon. The results of the analysis of a basic scenario show that conversion to organic farming is more profitable than staying conventional. In order to arrive at the actual profitable phase of organic farming, the farmer has to pass through the economically difficult 2-year conversion period. Sensitivity analysis shows that if depreciation is 25% higher than conventional fixed costs due to machinery made superfluous by conversion, conversion is less profitable than staying conventional. Also the availability of hired labour, which can be constrained in peak periods, has a strong effect on the cropping plan and the amount of area converted. Further analysis shows that a slight drop (2%) in organic prices lowers the labour income of the farmer and makes conversion less profitable than conventional farming. For farmers, a minimum labour income can be required to ‘survive’. The analysis shows that constraint on minimum labour income makes stepwise conversion the best way for farmers to overcome economic difficulties during conversion.     

土方机械落物保护结构动态仿真及试验

简述了土方机械落物保护结构的特点及性能要求,建立了落物保护结构受瞬态冲击响应的有限元结构动力学方程并提出了求解算法。以某装载机落物保护结构为例,建立了落物保护结构的非线性有限元模型,讨论了有限元网格划分及载荷施加方法,分析了落物保护结构的主要设计参数对冲击点最大位移及落锤速度和加速度的影响,并给出了更合理的结构。在试验台上对该装载机落物保护结构进行了落物冲击试验,试验结果和仿真结果吻合较好。落物保护结构的动态仿真为结构的设计提供了依据。     

曲轴模拟分析和测试技术的研究进展

曲轴的动力学特性对内燃机噪声、振动以及粗糙刺耳的音质的研究至关重要，因此必须尽可能准确地认识其内在机理。在曲轴模拟分析和测试技术研究领域中出现了许多成果．本文对这些成果作了简要介绍和分析。