Citrullinaemia in Friesian calves

Six Friesian calves from a pedigree herd died or were killed within 1 week of birth because of progressive central nervous disease in which the only consistent lesion was cerebral oedema. The cause was citrullinaemia, resulting from an autosomally inherited dysfunction of the urea cycle enzyme arginosuccinate synthetase. Citrullinaemia was diagnosed by demonstrating markedly elevated concentrations of citrulline in the blood of one calf and in the cerebral spinal fluid of another. One of two sires used in the herd was a heterozygous carrier of the disease. Heterozygocity was demonstrated using a polymerase chain reaction/restriction endonuclease test designed to detect the genetic mutation that causes citrullinaemia in cattle.     

Comparative studies of BHV-1 variants by in vivo--in vitro tests.

The new encephalitogenic BHV-1.3 and previously characterized BHV-1 strains were studied with reference to their immunogenic and protective potency and their antigenic relationships using "in vitro" and "in vivo" tests. The "in vitro" results obtained by neutralization kinetics showed that the Los Angeles (LA) strain (BHV-1.1) and a vaginal isolate L-114 strain (BHV-1.2) had antigenic similarities. Conversely, the behavior of the encephalitogenic strain A-663 (BHV-1.3), was significantly distinct. The "in vivo" protection test was carried out in calves using LA and A-663 strains. Post-vaccination antibodies and challenge with A-663 strain showed that the immunogenic behavior and protective capacities of both strains were similar. Neutralization kinetics differences between BHV-1.1 and BHV-1.3 did not alter the "in vivo" protection against BHV-1.3 challenge.     

A study of periodontal disease in sheep over a twelve month period

Sheep affected by broken mouth periodontal disease (P.D.) were examined over a twelve month period for different clinical parameters. It is suggested that P.D. in sheep is an episodic phenomenon similar to human P.D., and that only a few animals with signs of P.D. may undergo clinically significant destruction over a yearly period. No single parameter could reliably predict future deterioration in other parameters.     

Olmec settlement data from la venta, tabasco, Mexico

Research at La Venta, a major Olmec center on a low salt dome 12 kilometers from the Gulf Coast has revealed evidence of initial occupation (about 1750 to 1400 B.C.) along levees of the silted-in Río Barí, north of the site core in a transitional estuarine-riverine environment. Between 1400 and 1150 B.C. settlement expanded to nearby La Venta itself, which between 1150 and 800 B.C. developed into a major temple-town complex. Local development peaked at La Venta and along the river levees between 800 and 500 B.C. In this span La Venta headed a local three-tiered site hierarchy as social distinctions expanded to the peripheral Río Barí sites. New excavations show that growth in population size and density at La Venta preceded the development of sociopolitical complexity. These data contradict the traditional organizational reconstruction of Olmec society, the "vacant ceremonial center" model, and provide qualified support for a model that presents riverine resource concentration as a significant factor in the evolution of Olmec civilization.