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881.
Intraocular choristomas are rare anomalies in domestic animals and are often associated with multiple ocular malformations. A Thoroughbred foal presented for ocular abnormalities and was diagnosed with microphthalmia, corneal dermoids, severe anterior segment dysgenesis (including glandular choristomas), aphakia, retinal dysplasia, and optic nerve hypoplasia. Morphological, histochemical, and immunohistochemical comparisons were made between ocular choristomatous tissues from this foal and lacrimal gland, third eyelid gland, nasopharynx, trachea, and lacrimal sac/nasolacrimal duct from normal horses. Morphologically the choristomatous tissues (glands and epithelium lining the anterior segment) were most similar to the lacrimal sac. Histochemistry of glandular components found the glands associated with the lacrimal sac/nasolacrimal duct to be serous, as was the glandular intraocular choristomas. Our findings suggest that the origin of intraocular glandular choristomas in this case is from the lacrimal sac. 相似文献
882.
F. Adam E. Villiers S. Watson K. Coyne L. Blackwood 《Veterinary and comparative oncology》2009,7(3):181-195
Traditionally, classification of leukaemia in dogs has relied on morphological examination and cytochemical staining patterns, but aberrant cellular morphology and stain uptake often curtails accurate categorization, and historical data based on this classification may be unreliable. Immunophenotyping is now the gold standard for classification of leukaemias. The purpose of this prospective study was to assess the clinical pathological and epidemiological features of a population of dogs with morphologically and immunologically confirmed leukaemia and to compare them within categories: acute and chronic lymphoid leukaemia (ALL and CLL), and acute and chronic myeloid leukaemia (AML and CML). There were 64 cases of morphologically and immunologically confirmed leukaemia: 25 cases of ALL, 17 cases of CLL and 22 cases of AML. Prevalence of B and T immunophenotypes in ALL and CLL was not statistically different. Dogs with AML were significantly younger than those with ALL at presentation (P = 0.04). Golden Retriever dogs in the study population were overrepresented in comparison with a control population of dogs (6/25 ALL cases, 8/64 leukaemia cases). No sex was overrepresented. Dogs with ALL had significantly more severe neutropenia (P = 0.001) and thrombocytopenia (P = 0.002) than those with CLL and had significantly more cytopenias. The severity and numbers of cytopenias seen in ALL and AML were not significantly different. Twenty‐one of the leukaemia cases showed one cytopenia, fourteen had two cytopenias and twenty‐one cases had pancytopenia. Anaemia was the most common cytopenia seen in isolation (17/21). No dogs had neutropenia without anaemia and/or thrombocytopenia. Total white blood cell counts were not different between the groups. The atypical cell counts within the peripheral blood were significantly higher in ALL than AML; both in isolation and as a percentage of the total white blood cell count (P = 0.03). This study strengthens the hypothesis that acute leukaemias give rise to more profound cytopenias, affecting more cell lines, than chronic leukaemias. 相似文献
883.
Sean C Anderson Joanna Mills Flemming Reg Watson Heike K Lotze 《Fish and Fisheries》2011,12(3):317-339
In recent decades, invertebrate fisheries have expanded in catch and value worldwide. One increasingly harvested group is sea cucumbers (class Holothuroidea), which are highly valued in Asia and sold as trepang or bêche‐de‐mer. We compiled global landings, economic data, and country‐specific assessment and management reports to synthesize global trends in sea cucumber fisheries, evaluate potential drivers, and test for local and global serial exploitation patterns. Although some sea cucumber fisheries have existed for centuries, catch trends of most individual fisheries followed boom‐and‐bust patterns since the 1950s, declining nearly as quickly as they expanded. New fisheries expanded five to six times faster in 1990 compared to 1960 and at an increasing distance from Asia, encompassing a global fishery by the 1990s. Global sea cucumber production was correlated to the Japanese yen at a leading lag. Regional assessments revealed that population declines from overfishing occurred in 81% of sea cucumber fisheries, average harvested body size declined in 35%, harvesters moved from near‐ to off‐shore regions in 51% and from high‐ to low‐value species in 76%. Thirty‐eight per cent of sea cucumber fisheries remained unregulated, and illegal catches were of concern in half. Our results suggest that development patterns of sea cucumber fisheries are largely predictable, often unsustainable and frequently too rapid for effective management responses. We discuss potential ecosystem and human community consequences and urge for better monitoring and reporting of catch and abundance, proper scientific stock assessment and consideration of international trade regulations to ensure long‐term and sustainable harvesting of sea cucumbers worldwide. 相似文献
884.
T. Wesley Watson N. David Appel A. Michael Arnold M. Charles Kenerley 《The Journal of Horticultural Science and Biotechnology》2013,88(4):745-753
SummaryRoot distribution was determined for apple trees [Malus sylvestris (L.) Mill. var. domestica (Borkh.) Mansf. ‘Fuji’/’M.26’ (syn. M. domestica Borkh. non Poir.)] 1, 2 and 3 years after planting in trellised orchards in central Texas. Using a soil-coring method, measurable differences were detected in root-length density (RLD; root length per unit volume of soil) by tree age, soil depth, radial distance from the tree, and spatial bearing within and across rows (P ≤ 0.05). For fine roots (root diameters < 1 mm), mean RLD values were 0.1028, 0.1139 and 0.2911 cm cm–3 for 1, 2 and 3 year-old plantings, respectively. For coarse roots (root diameters 1–5 mm), mean RLD values were 0.0006, 0.0009 and 0.0015 cm cm–3 for 1, 2 and 3 year-old plantings, respectively. Mean RLD values declined for both fine and coarse roots of all ages with increasing soil depth and radial distance from the trunk (P ≤ 0.05). Similar patterns were observed for the number of soil cores containing measurable roots. The percentage of samples with no roots increased with increasing soil depth and distance from the trunk (P ≤ 0.05). When examining fine roots by spatial bearing from the tree, the greatest RLD was found along the drip irrigation lines for the two youngest plantings and along drip irrigation lines and beneath shaded trellises for the oldest planting (P ≤ 0.05). For coarse roots, the greatest RLD was found along the drip irrigation lines for all plantings (P ≤ 0.05). This information is important for predicting the rates and locations of new root growth in orchards after transplanting, so that management techniques (e.g., fertilisation, irrigation, control of soilborne diseases) can be properly targeted and effectively implemented. 相似文献
885.
Thomas C. Sparks Gerrit J. DeBoerNick X. Wang James M. HaslerMichael R. Loso Gerald B. Watson 《Pesticide biochemistry and physiology》2012,103(3):159-165
Sulfoxaflor [N-[methyloxido[1-[6-(trifluoromethyl)-3-pyridinyl]ethyl]-λ4-sulfanylidene] cyanamide] is in development as the first product from the new sulfoximine class of insect control agents. Highly effective against a variety of sap-feeding pest insects, available data indicate no cross-resistance to sulfoxaflor in pest insect strains that exhibit high levels of resistance to neonicotinoids and other insecticides. In vitro studies of the cytochrome P450 monooxygenase CYP6G1 from Drosophila melanogaster, expressed in a Drosophila cell line, show very high levels of metabolism for a variety of neonicotinoids, but not for sulfoxaflor and its chloropyridine-analog. A sulfoxaflor analog with nitrogen in place of the carbon in the bridge between the pyridine and sulfoximine moiety shows a modest degree of metabolism. In silico homology modeling of the CYP6G1 with the sulfoximines and neonicotinoids suggests that steric effects may limit interactions of the sulfoximines with the reactive heme-oxo complex. A distinct relationship was identified for the summed Hückel charges and the degree of metabolism observed. These observations help explain the lack of sulfoxaflor metabolism by CYP6G1, and in turn provide a basis for the lack of cross-resistance to sulfoxaflor in insecticide resistant strains of pest insects. 相似文献