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SUMMARY Beagles have been immunised against the paralysing effects of the Australian paralysis tick Ixodes holycyclus by allowing female ticks to feed on these dogs. Complete immunity to the toxic effects of lethal numbers of feeding ticks has persisted in these beagles for at least 53 weeks and in similarly-immunised foxhounds for at least 102 weeks, during which periods the beagles and foxhounds were kept free of ticks. Serum antitoxin titres increased to a maximum value (hyperimmunity) of 46 antitoxin units/mL with a minimum number of 11 ticks feeding simultaneously. Titres declined to a low level after 12 to 14 weeks of freedom from tick infestation but increased again on reinfestation with ticks. Large numbers of ticks (up to 60) appeared to be required after several stimulation/relaxation cycles to obtain hyperimmune levels of antitoxin in serum. The serum antitoxin titre appeared to be a good indicator of effective immunity to tick paralysis during the initial development of hyperimmunity but was less indicative thereafter, as dogs whose serum antitoxin titres had reached an apparent maximum remained immune to tick paralysis after titres had decreased to low levels. There was no evidence of cutaneous hypersensitivity or any other tick rejection mechanism that could account for this effect. 相似文献
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SUMMARY The arterial supply and venous drainage of 62 left and 5 right ovine adrenal glands is described, and the contribution of individual arteries to successful adrenal gland autotransplantation was evaluated. Arterial flow was measured by direct collection from the draining adrenal vein. Assessment of function of the transplanted adrenal gland was made from survival of the sheep and by the cortisol response to infusion of ACTH and the aldosterone secretory response to infusion of angiotensin II or potassium. For the left adrenal, the principal arterial supply was from the renal artery in 21 (34%), a lumbar artery in 32 (52%), and the anterior mesenteric artery in 3. The total blood flow was 5.0 ± SEM 0.4 mL/min, the flow from the renal branch 2.3 ± 0.3 mL/min, and the principal lumbar branch 2.6 ± 0.3 mL/min. Venous drainage from the left adrenal was via a major adrenal vein to the left renal vein, but additional tributaries to the renal vein were present in 26% . The arterial supply to the adrenal is regional and omission of a branch at transplantation could result in infarction of portion of the gland. By defining arterial supply and measuring blood flow, selection of the appropriate artery or multiple arteries can achieve an adrenal gland autotransplant survival of 90% . 相似文献
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JAYNE A. WRIGHT 《The Journal of small animal practice》1982,23(11):697-711
Spinal radiographs were made of fifty-nine cadavers and examined for the presence of vertebral osteophytes. The osteophytes were classified into two types and examined histologically. It was concluded that the end-plate osteophyte (type 1) represents spondylosis performans and that the type 2 osteophyte may fit into definition of the human condition, ankylosing hyperostosis. 相似文献
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JAYNE A. WRIGHT 《The Journal of small animal practice》1982,23(12):747-761
One hundred and four canine spinal radiographs were reviewed and the osteophytes present were categorized into four types. It is speculated that the type 1 osteophyte represents spondylosis deformans and types 2, 3 and 4, a condition similar to one found in man, namely ankylosing hyperostosis. 相似文献
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JAYNE A. WRIGHT 《The Journal of small animal practice》1978,19(1-12):267-271
The radiographic and histological features of an undifferentiated sarcoma invading the first three cervical vertebrae in a 6–month–old male Norwegian Buhund are described. The differential diagnosis of cervical pain is discussed. 相似文献