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151.
Tetsuya Imai Hisashi Takao Kunio Yamaguchi Toshiro Uchida Takeshi Goto Noriharu Umetsu 《Pest management science》1992,34(2):119-125
A series of imidazole-1-carboxylates was prepared by reacting various alcohols with trichloromethyl chloroformate and imidazole or N,N'-carbonyl-diimidazole. They were tested for fungitoxic activity in vitro against two phytopathogenic fungi, Botrytis cinerea (grey mould) and Gibberella fujikuroi, and for preventive efficacy against grey mould on cucumber leaves. 1-(4-Substituted phenoxymethyl)-2,2-dimethylpropylimidazole-1-carboxylates showed excellent in-vitro activity against B. cinerea, and moderate activity against G. fujikuroi, and some of them also effectively controlled grey mould in vivo. A 1H-1,2,4-triazole derivative corresponding to an imidazole derivative did not have any activity, while a thiocarboxylate corresponding to an imidazole carboxylate showed excellent activity against both B. cinerea and G. fujikuroi. 相似文献
152.
Asako Kobayashi Junya Sonoda Kazuhiko Sugimoto Motohiko Kondo Norio Iwasawa Takeshi Hayashi Katsura Tomita Masahiro Yano Toyohiro Shimizu 《Breeding Science》2013,63(3):339-346
Decline in the apparent quality of rice (Oryza sativa L.) grain due to high temperatures during ripening recently became a major concern in many areas in Japan. The occurrence of white-back kernels (WBK) is one of the main problems of heat-induced quality decline. We identified QTLs associated with the occurrence of WBK using recombinant inbred lines (RILs) and verified their effects using near-isogenic lines (NILs). The QTL analysis used F7 and F8 RILs derived from ‘Hana-echizen’ (HE), which is tolerant to high temperature, × ‘Niigata-wase’ (NW), which is sensitive to high temperature. Four QTLs were identified on chromosomes 3, 4, 6, and 9 (qWB3, qWB4, qWB6 and qWB9). To verify the effects of qWB6 and qWB9, we developed two NILs in which qWB6 or both were introduced from HE into the NW background. The HE allele at qWB6 significantly decreased WBK under multiple environments. The combination of qWB6 and qWB9 in an F2 population derived from a cross between a NIL and NW showed that the NW allele at qWB9 significantly decreased WBK if the qWB6 allele was HE. These results will be of value in marker-assisted selection for the breeding of rice with tolerance to heat-induced quality decline. 相似文献
153.
Tomoaki ONODA Ryuta YAMAMOTO Kyohei SAWAMURA Harutaka MURASE Yasuo NAMBO Yoshinobu INOUE Akira MATSUI Takeshi MIYAKE Nobuhiro HIRAI 《Journal of Equine Science》2013,24(4):63-69
Percentile growth curves are often used as a clinical indicator to evaluate variations of
children’s growth status. In this study, we propose empirical percentile growth curves
using Z-scores adapted for Japanese Thoroughbred horses, with considerations of the
seasonal compensatory growth that is a typical characteristic of seasonal breeding
animals. We previously developed new growth curve equations for Japanese Thoroughbreds
adjusting for compensatory growth. Individual horses and residual effects were included as
random effects in the growth curve equation model and their variance components were
estimated. Based on the Z-scores of the estimated variance components, empirical
percentile growth curves were constructed. A total of 5,594 and 5,680 body weight and age
measurements of male and female Thoroughbreds, respectively, and 3,770 withers height and
age measurements were used in the analyses. The developed empirical percentile growth
curves using Z-scores are computationally feasible and useful for monitoring individual
growth parameters of body weight and withers height of young Thoroughbred horses,
especially during compensatory growth periods. 相似文献
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Takeshi Toyoda Jun-ichi Akagi Young-Man Cho Yasuko Mizuta Saeko Onami Isamu Suzuki Kumiko Ogawa 《Journal of toxicologic pathology》2013,26(2):215-221
To evaluate the potential role of DNA repair in bladder carcinogenesis, we performed an immunohistochemical analysis of expression of various DNA repair enzymes and γ-H2AX, a high-sensitivity marker of DNA double-strand breaks, in the urothelium of male F344 rats treated with N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN), a bladder-specific carcinogen. Our results clearly demonstrated that γ-H2AX aggregation was specifically generated in nuclei of bladder epithelial cells of BBN-treated rats, which was not found in untreated controls or mesenchymal cells. γ-H2AX-positive cells were detected not only in hyperplastic and neoplastic areas but also in the normal-like urothelium after BBN treatment. These data indicate that γ-H2AX has potential as a useful biomarker for early detection of genotoxicity in the rat urinary bladder. To the best of our knowledge, this is the first report demonstrating expression of γ-H2AX during bladder carcinogenesis. 相似文献
158.
Yuichi Takai Tomoya Sano Takeshi Watanabe Ryo Fukuda 《Journal of toxicologic pathology》2013,26(3):319-323
This report describes the morphological and immunohistochemical characteristics of an
adrenocortical carcinoma with distant metastasis in a Sprague-Dawley rat. Macroscopically,
a single large mass was observed in the adrenal gland, and multiple nodules were noted in
the lung, liver and thyroid. Histologically, the adrenal tumor consisted of a solid growth
of eosinophilic round cells with nuclear atypia. Vascular invasion was present, and
multiple metastatic lesions were also observed in the lungs, liver, and mediastinal lymph
nodes. Immunohistochemically, the nuclei of these tumor cells were positive for
Steroidogenic Factor-1 (SF-1). In the thyroid, tumor cells histologically resembling
adrenal cells were immunohistochemically negative for SF-1 but positive for calcitonin;
thus the lesion was diagnosed as thyroid C-cell carcinoma. From these results, the present
case was diagnosed as adrenocortical carcinoma with distant metastases. SF-1 could be a
valuable marker for the differential diagnosis of adrenocortical tumors versus other
endocrine tumors such as C-cell carcinoma. 相似文献
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