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A computer-derived protocol using recursive partitioning to aid in estimating prognosis of horses with abdominal pain in referral hospitals
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P J Pascoe N G Ducharme G R Ducharme J H Lumsden 《Canadian journal of veterinary research》1990,54(3):373-378
In order to determine which variables are useful and accurate in estimating prognosis in horses with abdominal pain, data were analyzed from 231 horses presented at a veterinary teaching hospital. Using multiple stepwise discriminant analysis in a recursive partition model, we obtained a decision protocol that identified survivors and nonsurvivors. The prevalence of survivors was 61% in this population. The sensitivity, specificity, and positive and negative predictive values of this model were 71, 83, 87 and 65%, respectively. This decision protocol was validated by Jackknife classification and also by evaluation with a referral population of 100 horses in which the prevalence of survivors was 83%. This led to sensitivity, specificity, and positive and negative predictive values of 83, 78, 94 and 50%, respectively. 相似文献
84.
Neonatal critical care. 总被引:1,自引:0,他引:1
P F Moon B J Massat P J Pascoe 《Veterinary Clinics of North America: Small Animal Practice》2001,31(2):343-365
The first few minutes after a neonate's birth may determine the quality of its entire life. Immediate care includes prevention of hypothermia, clearing of nasal and oral passages, stimulation of ventilation and oxygenation, and, in a few cases, advanced life support. Any additional stress during the first weeks of life can also result in neonatal morbidity and mortality. Care of the diseased newborn must focus not only on treatment of the underlying disease but on aggressive supportive care. A safe, warm, clean, proper environment and adequate nutrition are essential. 相似文献
85.
White G McClure SR Sifferman R Holste JE Fleishman C Murray MJ Cramer LG 《Journal of the American Veterinary Medical Association》2007,230(11):1680-1682
OBJECTIVE: To determine the effects of 8 days of light to heavy exercise on gastric ulcer development in horses and determine the efficacy of omeprazole paste in preventing gastric ulceration. DESIGN: Randomized, controlled, multicenter clinical trial. ANIMALS: 102 horses with normal-appearing gastric mucosa on endoscopic examination that were in light to heavy training. PROCEDURES: Horses at 4 trial locations were allocated into replicates and sham dosed orally (empty syringe) or treated with a paste formulation of omeprazole (1 mg/kg [0.45 mg/ lb], PO) once daily for 8 days. Training regimens varied among locations and included early training for western performance events; walking, trotting, and cantering in a mechanical exerciser; and race training (2 locations). Prevalences of gastric ulceration at the completion of the 8-day treatment period were compared between groups. RESULTS: At the end of the 8-day treatment period, the proportion of omeprazole-treated horses free from gastric ulceration (88%) was significantly higher than the proportion of sham-dosed horses free from gastric ulceration (27%). CONCLUSIONS AND CLINICAL RELEVANCE: Results showed that horses in light to heavy training for as short as 8 days were at risk of developing gastric ulcers and that administration of omeprazole paste decreased the incidence of gastric ulcers. 相似文献
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Roger Hull 《Euphytica》1994,75(3):195-205
Summary Plant viruses cause considerable losses to crops and none of the three current approaches to disease control are likely to give the long-term answer. The new concept of non-conventional protection, in which the expression of a viral or virus-related sequence in the plant genome interferes with the virus infection cycle, holds considerable promise for designing new resistance or protection genes. A series of targets in the viral genome is identified and a range of mechanisms for attacking those targets is discussed. There are several current systems which have been proved to give protection, at least to a certain extent, and many systems which are being researched upon for the future. Some of these are described to give a picture of the current situation and of the thinking for the future. The problems of field deployment of the transgenic plants are discussed, especially those associated with the risk to the environment. Various questions which molecular biologists and plant breeders will have to consider include what are desirable characters to have in protection genes and how these new genes should be deployed. 相似文献
89.
Roger G. Pertwee 《Euphytica》2004,140(1-2):73-82
Summary Cannabis is the unique source of a set of at least 66 compounds known collectively as cannabinoids. Of these, most is known about the pharmacology of 9-tetrahydrocannabinol (9-THC), the main psychoactive constituent of cannabis, and about cannabidiol (CBD), which lacks psychoactivity. Accordingly, this paper focuses on the pharmacological and therapeutic targets of these two cannabinoids. Many of the effects of 9-THC are mediated by cannabinoid receptors of which at least two types, CB1 and CB2, are present in mammalian tissues. Endogenous agonists for cannabinoid receptors have also been discovered. CB1 receptors are present at the terminals of central and peripheral neurones, where they modulate transmitter release. They also exist in some non-neuronal cells. CB2 receptors are expressed mainly by immune cells, one of their roles being to alter cytokine release. 9-THC also appears to have non-CB1, non-CB2 pharmacological targets. It is already licensed for clinical use in the U.S.A. as an anti-emetic and appetite stimulant and both 9-THC and 9-THC-rich cannabis extracts show therapeutic potential as neuroprotective and anticancer agents and for the management of glaucoma, pain and various kinds of motor dysfunction associated, for example, with multiple sclerosis and spinal cord injury. CBD has much less affinity for CB1 and CB2 receptors than 9-THC and its pharmacological actions have been less well characterized. Potential clinical applications of CBD and CBD-rich cannabis extracts include the production of anti-inflammatory and neuroprotective effects, the management of epilepsy, anxiety disorders, glaucoma and nausea, and the modulation of some effects of 9-THC. 相似文献
90.
No information is available on the effects of different biomass yield environments on selection efficiency in switchgrass
(Panicum virgatum L.) breeding improvement. This study was conducted to assess the effects of high- and low-biomass yield environments (HYE
and LYE, respectively) on recurrent selection for general combining ability (RSGCA) in a lowland population of switchgrass
(NL-94). The top 14 of 65 NL-94 C0 parent plants were selected based on biomass yield of half-sib (HS) progeny tested for one post-establishment year under HYE
and LYE conditions. Nine of the 14 C0 parent plants were the same based on HS performance under HYE and LYE. Selected plants were intercrossed to produce NL-94
HYE and NL-94 LYE C1 populations. One hundred and twenty-five HS C1 progeny families (60 NL-94 HYE and 65 NL-94 LYE) were evaluated for biomass yield for 3 years (2002–2004) under HYE and LYE
conditions. The HYE produced about 2.5 times higher biomass yields than the LYE in both C0 and C1 HS progeny tests. Estimated additive genetic variance and predicted gains from selection (ΔG) were high in the C1 populations indicating that RSGCA should achieve higher biomass yields. Mean biomass yields of C1 HS families originating from the LYE protocol were significantly higher than those of families originating from the HYE protocol
in both HYE and LYE performance tests, suggesting greater selection response under LYE in the C0 population. The estimates of narrow-sense heritability (
) and ΔG from the C1 populations indicate that positive response to selection for biomass yield is possible in subsequent cycles of selection
under either HYE or LYE, with a possible small advantage for HYE. 相似文献