Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity

Cyclic nucleotides are second messengers that are essential in vision, muscle contraction, neurotransmission, exocytosis, cell growth, and differentiation. These molecules are degraded by a family of enzymes known as phosphodiesterases, which serve a critical function by regulating the intracellular concentration of cyclic nucleotides. We have determined the three-dimensional structure of the catalytic domain of phosphodiesterase 4B2B to 1.77 angstrom resolution. The active site has been identified and contains a cluster of two metal atoms. The structure suggests the mechanism of action and basis for specificity and will provide a framework for structure-assisted drug design for members of the phosphodiesterase family.     

Whither or wither microbicides?

After disappointing results from all efficacy trials conducted to date, the field of microbicides research now faces substantial challenges. Poor coordination among interested parties and the choice of nonvalidated scientific targets for phase III studies have hampered progress and created mistrust about the use of microbicides as a method to prevent HIV-1 sexual transmission. Although new promising strategies are available, there will need to be serious reappraisals of how decisions are made to advance the next generations of candidates into clinical trials, and the use of appropriate animal models in this process will be critical.     

Comment on "Deep mixing of 3He: reconciling Big Bang and stellar nucleosynthesis"

Eggleton et al. (Reports, 8 December 2006, p. 1580) reported on a deep-mixing mechanism in low-mass stars caused by a Rayleigh-Taylor instability that destroys all of the helium isotope 3He produced during the star's lifetime. Observations of 3He in planetary nebulae, however, indicate that some stars produce prodigious amounts of 3He. This is inconsistent with the claim that all low-mass stars should destroy 3He.     

Carbon flux and growth in mature deciduous forest trees exposed to elevated CO2

Whether rising atmospheric carbon dioxide (CO2) concentrations will cause forests to grow faster and store more carbon is an open question. Using free air CO2 release in combination with a canopy crane, we found an immediate and sustained enhancement of carbon flux through 35-meter-tall temperate forest trees when exposed to elevated CO2. However, there was no overall stimulation in stem growth and leaf litter production after 4 years. Photosynthetic capacity was not reduced, leaf chemistry changes were minor, and tree species differed in their responses. Although growing vigorously, these trees did not accrete more biomass carbon in stems in response to elevated CO2, thus challenging projections of growth responses derived from tests with smaller trees.     

我国外来生物入侵现状及防范对策

分析我国外来生物入侵所造成的危害,主要是对农林业、生态环境、生物多样性、人类健康和国家安全造成破坏和威胁;外来生物入侵的途径主要有生物自然扩散传播、人为引种传入、随国际贸易往来传入等;目前我国的防范工作主要有3个方面,即检验检疫部门在口岸一线检疫防控,农林部门引种审批与病虫害防治,环保部门生态环境治理等,各部门均取得了成效,但也存在薄弱环节和问题。在分析形势、现状和问题的基础上,提出5点对策建议:一是落实科学发展观,提高全社会对防范工作重要性的认识;二是制定和完善相关法规,保证防范工作均有法可依;三是理顺关系明确职责,建立多部门齐抓共管机制;四是强化口岸检疫措施,筑牢第一道防线;五是建立健全外来生物监控网络,保障防范工作及时有效。     

Particle Track, X-ray, Thermal, and Mass Spectrometric Studies of Lunar Material

Particle tracks in Apollo 11 samples are dominantly of cosmic ray and solar origin: primary galactic and solar flare particles, likely spallation recoil tracks, and possible solar-wind heavy particles. The energy spectrum of irongroup nuclei is inferred from track density gradients in surface layers, and a limit of < 10(-7) centimeter per year is deduced for the surface erosion rate. From cosmic ray tracks in rock and core samples it is clear that the lunar soil is stirred often during each few million years. X-rays reveal augite, anorthite, olivine, ilmenite, troilite, nonmeteoritic iron, and assorted glasses, but no major structural damage. Hydrogen, helium, and other gases in the fines are compatible with expected solar wind ratios.     

Atlantic Ocean forcing of North American and European summer climate

Recent extreme events such as the devastating 2003 European summer heat wave raise important questions about the possible causes of any underlying trends, or low-frequency variations, in regional climates. Here, we present new evidence that basin-scale changes in the Atlantic Ocean, probably related to the thermohaline circulation, have been an important driver of multidecadal variations in the summertime climate of both North America and western Europe. Our findings advance understanding of past climate changes and also have implications for decadal climate predictions.