The immune response of the pig following oral immunisation with soluble protein

The immune response of pigs fed 200 mg per day of dinitrophenylated bovine gamma globulin has been evaluated in terms of the antibody and lymphocyte responses and of the induction of tolerance and immune exclusion. Although dosing for ten days resulted in a small IgA response as indicated by splenic plaque forming cells, serum antibody could only be detected when dosing was continued for 42 days. secretory antibody was detected at any time. Antigen feeding for two weeks rendered the animals hyporesponsive to subsequent parenteral antigenic challenge but had little effect upon their ability to exclude an oral dose of antigen from the circulation.     

Effect of Tomanol on the pharmacokinetics and tissue distribution of penicillin G in dairy cows

Following concomitant intravenous administration of Tomanol and sodium penicillin G to six Dutch Friesian dairy cows a significant decrease in total body clearance of penicillin (34.7%) and a prolongation of the elimination half-life of penicillin (17.2%) was observed. Tomanol did not affect other pharmacokinetic parameters such as rate constants of drug transfer (k12/k21, alpha en beta), distribution volume of the central compartment (V1), and extrapolated serum drug levels. Intravenous or intramuscular administration of Tomanol had no effect on the tissue distribution of penicillin G, because neither a change in the ratios of muscle to serum and of kidney cortex to serum nor a change in an induced steady state level of low penicilline G serum concentrations was observed. From the data obtained it is concluded that concomitant Tomanol administration with penicillin induces an elevation of the serum penicillin concentration and prolongs the persistence of penicillin residues in carcass meat and organs.     

Une néphrose toxique chez des veaux traités par un médicament contenant des produits de dégradation des tétracyclines

A toxic nephrosis in calves treated with a drug containing tetracycline degradation products     

The recent divergence of regional per capita incomes: some evidence from Australia

"This paper focuses upon interregional income divergence in Australia where a pattern very similar to that seen in the United States is discovered. Australian agricultural regions show downward divergence from the national mean per capita income and capital city regions show upward divergence."