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81.
Avril Hamel-Jolette Marilyn Dunn Christian Bdard 《Canadian journal of veterinary research》2009,73(1):73-76
Plateletworks is a screening assay used in human medicine to monitor platelet-inhibiting drugs. As arterial thromboembolism is a common complication in cats suffering from cardiomyopathy, they are often treated with anti-platelet medication. Clopidogrel (Plavix), an anti-platelet aggregation drug, has recently been evaluated in healthy cats. The purpose of this study was to determine if the Plateletworks method can detect a decrease in platelet aggregation in cats receiving clopidogrel. Nine healthy adult cats were used for this study. Platelet aggregation was measured before and after a 3-day clopidogrel treatment (18.75 mg SID). Platelet aggregation after the clopidogrel treatment was significantly lower (P < 0.01). The Plateletworks method appears to be a promising test to monitor clopidogrel therapy in cats. 相似文献
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Jan Borovi?ka Colin E. Dunn Martin Mihaljevi? Jan Rohovec Zdeněk ?anda 《Soil biology & biochemistry》2010,42(1):83-15
Samples of macrofungi collected in the vicinity of the Mokrsko gold deposit were analyzed for Au by INAA and ICP-MS. Ectomycorrhizal fungi yielded from 0.88 to 564 μg kg−1 Au (dry weight) in 79 samples. Saprobic fungi (75 samples) from the same locations yielded significantly higher concentrations: 3-7739 μg kg−1 Au (dry weight), with the highest contents in Lycoperdon perlatum. These are the highest recorded concentrations of Au in naturally-occurring fungi/vascular plants. Concentrations of Au in ectomycorrhizae were approximately 4-10 times higher than those in fine roots. It appears that saprobic fungi, namely several terrestrial saprobes of the genera Agaricus and Lycoperdon, are more efficient than ectomycorrhizal fungi at taking up Au, probably assisted by other microbiota and/or by a range of naturally-occurring compounds that have yet to be identified. The present data demonstrate that macrofungi are involved in the biogeochemical cycling of Au. 相似文献
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1. An F2 cross of a broiler male line and a White Leghorn layer line was used to identify quantitative trait loci (QTL) for bone density at the onset of lay and at the end of the laying period. A total of 686 measures of humeral bone density were available for analysis. 2. There was no evidence for epistasis. 3. Genome-wide significant QTL for bone density at the onset of lay were identified on chromosomes 1 (311?cM) and 8 (2?cM) and on chromosomes 1 (311?cM), 3 (57?cM) and 8 (2?cM) with a covariate for the number of yellow follicles (a proxy for the concentration of circulating oestrogen). 4. Evidence for only 4 chromosome-wide suggestive QTL were detected at the end of lay (72 weeks). 5. Analysis of the combined data confirmed two genome-wide suggestive QTL on chromosome 1 (137 and 266?cM) and on chromosomes 8 (2?cM) and 9 (10?cM) in analyses with or without the covariate. 6. Positive QTL alleles came from the broiler line with the exception of 2 suggestive QTL at the onset of lay on chromosomes 3 and 5 in an analysis with the covariate. 7. In general, QTL acted additively, except that dominant effects were identified for three suggestive QTL at the onset of lay on chromosomes 3 (57 and 187?cM) and 5 (9?cM). 8. The significant QTL in this study were at similar locations to QTL identified in a range of crosses in other publications, suggesting that they are prime candidates for the search for genes and mutations that could be used as selection criteria to improve bone strength and decrease fractures in commercial laying hens. 相似文献
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87.
Estep JS Baumgartner RE Townsend F Pabst DA McLellan WA Friedlaender A Dunn DG Lipscomb TP 《Veterinary pathology》2005,42(3):357-359
Seminoma with metastasis was diagnosed in a spotted dolphin (Stenella frontalis) and an Atlantic bottlenose dolphin (Tursiops truncatus). Sertoli cell tumor and pheochromocytoma were also diagnosed in the spotted dolphin. The spotted and bottlenose dolphins were adult males that stranded and died on the coasts of northwest Florida and southeast North Carolina, respectively. Neoplasia is infrequently reported in cetaceans. This is the first report of seminoma, Sertoli cell tumor, and pheochromocytoma in a dolphin, the first report of three distinct neoplasms in a dolphin, and one of the few reports of malignant neoplasia in dolphins. 相似文献
88.
Lu H Dunn PA Wallner-Pendleton EA Henzler DJ Kradel DC Liu J Shaw DP Miller P 《Avian diseases》2004,48(1):26-33
An avian influenza (AI) outbreak occurred in meat-type chickens in central Pennsylvania from December 2001 to January 2002. Two broiler breeder flocks were initially infected almost simultaneously in early December. Avian influenza virus (AIV), H7N2 subtype, was isolated from the two premises in our laboratory. The H7N2 isolates were characterized as a low pathogenic strain at the National Veterinary Services Laboratories based on molecular sequencing of the virus hemagglutinin cleavage site and virus challenge studies in specific-pathogen-free leghorn chickens. However, clinical observations and pathologic findings indicated that this H7N2 virus appeared to be significantly pathogenic in meat-type chickens under field conditions. Follow-up investigation indicated that this H7N2 virus spread rapidly within each flock. Within 7 days of the recognized start of the outbreak, over 90% seroconversion was observed in the birds by the hemagglutination inhibition test. A diagnosis of AI was made within 24 hr of bird submission during this outbreak using a combination of virus detection by a same-day dot-enzyme-linked immunosorbent assay and virus isolation in embryonating chicken eggs. Follow-up investigation revealed that heavy virus shedding (90%-100% of birds shedding AIV) occurred between 4 and 7 days after disease onset, and a few birds (15%) continued to shed virus at 13 days post-disease onset, as detected by virus isolation on tracheal and cloacal swabs. AIV was not detected in or on eggs laid by the breeders during the testing phase of the outbreak. The two flocks were depopulated at 14 days after disease onset, and AIV was not detected on the two premises 23 days after depopulation. 相似文献
89.
Scott Willens J Lawrence Dunn Salvatore Frasca 《Journal of zoo and wildlife medicine》2004,35(1):107-109
An adult, male, captive lined seahorse (Hippocampus erectus) was presented with weight loss, anorexia, and brood pouch distention. Initial treatments included manual expression of the brood pouch followed by saline flushes and enrofloxacin infusions. Radiographs and physical examination identified a nodular swelling in the brood pouch wall. The mass was excised, but the seahorse died. Necropsy and histopathology revealed a malignant mesenchymal tumor with a collagenous stroma, and a brood pouch fibrosarcoma was diagnosed. 相似文献
90.