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71.
Duchêne S Métayer S Audouin E Bigot K Dupont J Tesseraud S 《Domestic animal endocrinology》2008,34(1):1-13
p70 S6 kinase (p70S6K) is a key enzyme involved in the control of protein synthesis. We have previously shown that this kinase is insulin sensitive in chicken muscle despite a relative insulin resistance in the early steps of insulin receptor signaling in this tissue, particularly with no change in tyrosine phosphorylation of the insulin receptor substrate 1 (IRS1). The aim of the present study is to further study the p70S6K pathway in chicken muscle. By analyzing in silico several kinases involved in the protein kinase B (PKB also called AKT)/target of rapamycin (TOR)/p70S6K pathway in the chicken, we showed that the amino acid sequence of the proteins exhibited a very high identity with their homologs in mammalian species and Drosophila. We investigated the regulation of these kinases in vivo or in vitro. Refeeding and insulin treatment significantly (P<0.05) increased the phosphorylation and/or activity of kinases upstream of p70S6K such as AKT and TOR. Similarly, refeeding and insulin increased the phosphorylation of p70S6K on key residues (i.e. T389, T229 and T421/S424) and the phosphorylation of a p70S6K downstream target, the ribosomal protein S6 (by 3-10-fold, P<0.05). Interestingly, we also showed an increase in the phosphorylation level of IRS1 on S632/S635, sites involved in insulin resistance. In conclusion, the AKT/TOR/p70S6K pathway is activated by refeeding and insulin injection, which might negatively regulate IRS1 tyrosine phosphorylation. These results indicate some particularities of the insulin signaling in chicken muscle and suggest the involvement of p70S6K in these features. 相似文献
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Alfaxalone for total intravenous anaesthesia in bitches undergoing elective caesarean section and its effects on puppies: a randomized clinical trial 下载免费PDF全文
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Bruna Rodrigues Willhelm Elvis Ticiani Karine Campagnolo Gabriella Borba de Oliveira Karine de Mattos Camilo Andrés Peña Bello Felipe Ledur Ongaratto Paula Rodriguez-Villamil Luciana Relly Juliana Paula Martins Alves Davide Rondina José Luiz Rigo Rodrigues Marcelo Bertolini 《Reproduction in domestic animals》2021,56(6):857-863
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Marc Kent Erin M. Beasley Karine P. Gendron Maëva C.M. Barozzi Christina Marino 《The Canadian veterinary journal. La revue veterinaire canadienne》2021,62(6):592
A mixed-breed pygmy goat was presented for nonambulatory tetraparesis. Neurological examination was consistent with a C6 to T2 myelopathy. Initially, the goat was treated medically. Forty-three days later, magnetic resonance imaging (MRI) revealed an extradural mass compressing the cervical spinal cord. Magnetic resonance attributes of the mass were consistent with a slow-growing, fluid-poor lesion. The spinal cord was surgically decompressed. Epidural empyema secondary to Fusobacterium necrophorum was identified. Postoperative care consisted of anti-inflammatory medication, antimicrobials, and physical therapy. Ability to walk occurred by day 14 after surgery. Despite prolonged recumbency before surgery, the goat was clinically normal, and antimicrobials were discontinued on day 60 after surgery.Key clinical message:Epidural empyema can cause a compressive myelopathy which may result in varying degrees of paresis/paralysis. Clinical resolution and return of normal function occurred following the use of MRI to plan surgical decompression combined with extended use of antimicrobials. 相似文献
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Inga-Catalina Cruz Benedetti Knut Nottrott Isabelle Fourel Marjolaine Le Bris Emilie Mongellas Karine Portier 《Veterinary anaesthesia and analgesia》2017,44(1):63-69
Objectives
To compare the effects of a lidocaine constant rate infusion (CRI) combined with 1% isoflurane versus those of 2% isoflurane alone on cardiovascular variables in anaesthetized horses, and to estimate the sample size required to detect a difference in recovery quality.Study design
Prospective, randomized, blinded, crossover study.Animals
Twelve healthy experimental horses.Methods
Horses were anaesthetized twice using an intravenous (IV) administration of acepromazine, romifidine, diazepam and ketamine. Horses were placed in dorsal recumbency and ventilated mechanically. During the first 10 minutes (P1), anaesthesia was maintained with a 2% inspired isoflurane fraction (FIIso). During the following 20 minutes (P2), horses received IV lidocaine (1.5 mg kg?1) (group IL) or saline (group I). During the last 60 minutes (P3), group IL received a lidocaine CRI (50 μg kg?1 minute?1 IV) and FIIso 1%, whereas group I received a saline CRI and FIIso 2%. Three weeks later, the horses received the alternative treatment. Painful stimuli were induced by introducing an 18 gauge needle intramuscularly. Ketamine and dobutamine requirements and physiological variables were recorded. Recoveries were assessed by two anaesthetists unaware of the treatment. Lidocaine plasma concentrations were measured during recovery. Data were analysed with anova.Results
During P3, group IL had a lower heart rate (p = 0.002), higher mean arterial pressure (p < 0.001) and lower dobutamine requirement (p < 0.001) than group I. One horse had lidocaine plasma concentrations above toxic levels. Recoveries did not differ significantly between groups. Sample sizes of 208 horses in each group would be necessary to detect a statistically significant difference (85% statistical power) in recovery quality.Conclusions and clinical relevance
A lidocaine CRI combined with FIIso 1% rather than FIIso 2% alone may improve cardiovascular variables in healthy anaesthetized horses. 相似文献80.