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21.
FEASIBILITY FOR USING HYPOFRACTIONATED STEREOTACTIC VOLUMETRIC MODULATED ARC RADIOTHERAPY (VMAT) WITH ADAPTIVE PLANNING FOR TREATMENT OF THYMOMA IN RABBITS: 15 CASES 下载免费PDF全文
Mario Dolera Luca Malfassi Giovanni Mazza Gaetano Urso Massimo Sala Silvia Marcarini Nancy Carrara Simone Pavesi Sara Finesso Michael S. Kent 《Veterinary radiology & ultrasound》2016,57(3):313-320
Thymoma is a relatively common tumor in rabbits. Treatment with surgery, radiation therapy, and chemotherapy alone or in combination has been reported with varying outcomes. Stereotactic volumetric modulated arc radiotherapy delivered in a hypofractionated manner allows high doses of radiation to be delivered to the target volume while allowing sparing of adjacent critical structures. This therapy is ideally suited for thymomas in rabbits given their size, the difficulty of multiple anesthesia episodes and the complexity of the radiotherapy plans required due to the tumor's proximity to the heart, lungs, and mediastinal structures. Fifteen rabbits with thymoma were prospectively recruited for this observational, single institution, single arm clinical study. All rabbits were imaged with both computed tomography (CT) and magnetic resonance imaging (MRI). A total dose of 40 Gy in six fractions was delivered using a single arc over an 11‐day period with repeat CT simulation done every other fraction for adaptive planning. Follow‐up evaluation was done through repeat CT and MRI imaging and revealed complete responses using the Response Evaluation Criteria in Solid Tumors (RECIST) criteria. Two rabbits had died at 618 and 718 days, 10 were alive and three were lost to follow‐up. Observed acute and late effects were graded according to the Veterinary Radiation Therapy Oncology Group (VRTOG) criteria and were found to be minimal. 相似文献
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Lasse Dam Rasmussen Giovanni Savini Alessio Lorusso Anna Bellacicco Massimo Palmarini Marco Caporale Thomas Bruun Rasmussen Graham J Belsham Anette B?tner 《Veterinary research》2013,44(1):75
Transplacental transmission of bluetongue virus has been shown previously for the North European strain of serotype 8 (BTV-8) and for tissue culture or chicken egg-adapted vaccine strains but not for field strains of other serotypes. In this study, pregnant ewes (6 per group) were inoculated with either field or rescued strains of BTV-2 and BTV-8 in order to determine the ability of these viruses to cross the placental barrier. The field BTV-2 and BTV-8 strains was passaged once in Culicoides KC cells and once in mammalian cells. All virus inoculated sheep became infected and seroconverted against the different BTV strains used in this study. BTV RNA was detectable in the blood of all but two ewes for over 28 days but infectious virus could only be detected in the blood for a much shorter period. Interestingly, transplacental transmission of BTV-2 (both field and rescued strains) was demonstrated at high efficiency (6 out of 13 lambs born to BTV-2 infected ewes) while only 1 lamb of 12 born to BTV-8 infected ewes showed evidence of in utero infection. In addition, evidence for horizontal transmission of BTV-2 between ewes was observed. As expected, the parental BTV-2 and BTV-8 viruses and the viruses rescued by reverse genetics showed very similar properties to each other. This study showed, for the first time, that transplacental transmission of BTV-2, which had been minimally passaged in cell culture, can occur; hence such transmission might be more frequent than previously thought. 相似文献
24.
Prognostic value of echocardiographic indices of left atrial morphology and function in dogs with myxomatous mitral valve disease 下载免费PDF全文
25.
Salvatore Alonge Monica Melandri Giulio Aiudi Giovanni Michele Lacalandra 《Topics in companion animal medicine》2018,33(4):105-108
In last years, following the increased canine life expectancy and the rising attention pet-owners devote to their animals, several authors have carried on investigations concerning new techniques to early identify canine prostatic disorders that might affect the dog's quality of life. Prostatic disorders often have an asymptomatic onset and their early diagnosis is difficult: hence, they are usually identified at an advanced stage, only. Traditionally, the diagnosis of prostatic disorders is based on noninvasive tools, such as transrectal and abdominal palpation, seminal or prostatic fluid evaluation, and urinalysis and imaging. On the other hand, a definite diagnosis of prostatic abnormalities could be achieved through prostatic parenchyma Fine Needle Aspiration (FNA) or biopsy. However, these investigations are performed rarely because of their invasiveness. Thus, several authors investigated canine serum biomarkers in order to achieve an earlier diagnostic timing and to apply therapeutic strategies for better outcomes. The Canine Prostatic Specific Esterase (CPSE) has been identified as a suitable biomarker to be included in a prostate health screening program, following the model of prostate-specific antigen (PSA) in human medicine. A higher CPSE in dogs suffering from several prostatic diseases, such as benign prostatic hyperplasia, bacterial prostatitis, or prostatic carcinoma, was reported in literature. Thanks to the potential usefulness in clinical practice, further studies should investigate the potential role of CPSE in monitoring the medical treatment success in the male reproductive system. Moreover, the spreading availability of serum biomarkers, easily carried out on blood samples in clinical practice, could assure a more accurate evaluation of the actual prevalence of prostatic disorders. The CPSE is actually recognized as a promising diagnostic tool for the detection of prostatic disorders in a "prostate health screening program," in order to properly select those patients requiring further more accurate and expensive diagnostic investigations. 相似文献
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Paolo Zucca Giovanni Di Guardo Roberto Pozzi-Mucelli Dino Scaravelli Marco Francese 《Journal of zoo and wildlife medicine》2004,35(3):391-394
A mature male Risso's dolphin (Grampus griseus) stranded along the coasts of Friuli Venezia Giulia, northeast Italy, in May 2001. Parasitic infection with Crassicauda grampicola is often found in the tympanic bullae and pterygoid sinuses in many of the Risso's dolphins examined from the same area. For this reason, it was decided to perform computed tomography of the head to assess this imaging technique for the diagnosis of crassicaudosis in dolphins. A full postmortem examination confirmed the pathologic findings of the computed tomography scan. This technique can be considered a useful adjunct in the diagnosis of cranial crassicaudosis in live dolphins. 相似文献
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Giovanni Gualtieri 《Water, air, and soil pollution》2010,212(1-4):461-482
Assessing air quality in street canyons is a crucial concern, as the highest pollution levels and threshold exceedances are usually experienced within this kind of urban streets. A brief overview based on experimental studies and modelling techniques undertaken in literature is presented, including characteristic features affecting wind flow and pollutant dispersion within street canyons. In this work, a numerical street canyon model intercomparison has been performed in a typical urban canyon in Florence, Italy. In particular, STREET, Canyon Plume Box Model (CPBM) and Operational Street Pollution Model (OSPM) have been applied to compute the street-level 1-h carbon monoxide (CO) concentrations. In addition, the CALINE4 model has been applied to test the site morphology. Input data cover a 1-year time period and include meteorological observations as well as measured traffic volumes and driving speeds. Hourly road emissions have been calculated using the COPERT methodology taking into account vehicle fleet, traffic flows and driving speed, as well as ambient temperature to account for cold overemissions. A preliminary experimental data analysis has been carried out in order to investigate the dependence of observed CO concentrations on meteorological and traffic parameters. Hourly CO concentrations observed over the full year have been used to compare the STREET, CPB and OSP models, resulting in a detailed statistical analysis carried out by wind sector as well as on a seasonal basis. 相似文献
29.
Matteo Patergnani Lapo Mughini Gras Giovanni Poglayen Aldo Gelli Fernando Pasqualucci Marco Farina Laura Stancampiano 《Journal of pest science》2010,83(3):347-359
Anticoagulant poisoning is a common rodent control method in urban areas, but rodents may exhibit versatile feeding behavioural
habits in varying environmental conditions. This study has been conducted to determine those environmental factors that could
directly influence bait consumption and which therefore may affect an urban rodent control plan carried out with chemical
methods. In the city of Bologna (Italy), 2500 bait stations have been monitored in various urban biotopes and the bait consumption
studied in relation to several environmental factors, using both bivariate and multivariate analysis. Results reveal that
the rodent patch distribution triggers the avoidance of baits placed outside of their home-range, hence the importance on
bait placement. The logistic regression model confirms that vegetation, harbourage and water supplies are important variables
in determining bait consumption, probably because they may spatially and temporarily facilitate the agoraphobic rodent movement,
ensuring undisturbed bait consumption. The role of predators (dogs and cats) and food competitors (synanthropic birds) remains
insignificant. However, bait eating invertebrates may consume part of the bait. For a proper rodent control plan the first
real need is to minimize the alternative food sources, which may compete with baits. Weather conditions in which rodents could
possibly pass unnoticed (fog and rainfall) may encourage bait consumption, vice versa with a cold climate. The considered
environmental factors have satisfactorily explained bait consumption, highlighting the importance of human influence. The
study of environmental factors may be useful in categorizing several site-specific conditions where rodent control efforts
should be targeted, enhancing any intervention by matching the correct and specific strategy. 相似文献
30.