Mortality in early born, housed lambs in south-west England

During a 2 year study of diseases in lambs in three early lambing (housed) flocks a total of 428 of 4413 (9.7%) lambs died. All these lambs were examined at post mortem by one investigator who used a routine procedure. Results were stored on a database (dBase III Plus) and analysed using Epiinfo. The peak rate of death occured in lambs less than 1 week old. Over 50% of deaths took place in this period. A small proportion of lambs (approximately 10 out of 1000) died during the prenatal period. Fatalities included chlamydial and mycotic abortions, but in the majority of cases there was no specific abortive agent, lambs were either freshly dead or mummified. Partum deaths (23.3–45.1 per 1000) were categorised into those due to the lambing process, lambs born dead and congenital defects. The most frequent abnormality observed was subcapsular liver rupture (9.3–20.9 per 1000) with up to 60% of affected lambs also having signs of malpresentation (subcutaneous oedema of the neck). Early postpartum deaths (12.9–31.5 per 1000) were primarily associated with starvation.     

NONHUMAN PRIMATE EXCRETORY UROGRAPHY*

Survey radiographs have not accurately identified renal contour or location in nonhuman primates. Excretory urography using 786 to 1193 mg iodinelkg body weight resulted in dense opacification of the renal parenchyma and pelvis. Abdominal compression improved visu- alization of the renal pelvis. Interpretation of the nonhuman primate excretory urogram was compromised by several anatomic characteristics of this animal group. Superimposition of the kidneys on the lateral radiograph limited evaluation of the renal contour. Since the renal pelvis in most species of nonhuman primates does not possess diverticula (as in the dog and cat) or a caliceal system (as in the pig and man), the diagnosis of pyelonephritis or renal mass lesions was difficult. Severe irregularities in the renal contour, size of the renal pelvis, or areas of deficient concentrating ability were identifiable in nonhuman primate excretory urograms, but the diagnosis of small cysts was not possible in smaller nonhuman primates. The presence of a caliceal collecting system in the spider monkey (Ateles sp.) suggests this animal as a potential model for the evaluation of human renal disease.     

Evaluation of tulathromycin for the treatment of pneumonia following experimental infection of swine with Mycoplasma hyopneumoniae

Tulathromycin was evaluated in the treatment of pneumonia in weaned pigs inoculated intranasally with Mycoplasma hyopneumoniae. Five days postchallenge, the pigs were randomized to treatment with a single IM administration of saline, a single IM administration of tulathromycin (2.5 mg/kg; day 0), or three IM administrations of enrofloxacin (5.0 mg/kg; days 0, 1, 2). Pigs were necropsied on day 12 or 13. Unchallenged controls remained healthy with no lung pathology. Compared with saline, coughing, mean lung lesion score, and proportional lung weight were significantly reduced and weight gain was significantly greater for tulathromycin-treated pigs (P < .05). Compared with enrofloxacin, there were no significant differences in proportional lung weight or weight gains, but coughing and lung lesion scores were greater for tulathromycin-treated pigs (P < .05). Tulathromycin was effective in the treatment of pneumonia following experimental infection with M. hyopneumoniae.