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排序方式: 共有1598条查询结果,搜索用时 15 毫秒
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Picard C Puel A Bonnet M Ku CL Bustamante J Yang K Soudais C Dupuis S Feinberg J Fieschi C Elbim C Hitchcock R Lammas D Davies G Al-Ghonaium A Al-Rayes H Al-Jumaah S Al-Hajjar S Al-Mohsen IZ Frayha HH Rucker R Hawn TR Aderem A Tufenkeji H Haraguchi S Day NK Good RA Gougerot-Pocidalo MA Ozinsky A Casanova JL 《Science (New York, N.Y.)》2003,299(5615):2076-2079
Members of the Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) superfamily share an intracytoplasmic Toll-IL-1 receptor (TIR) domain, which mediates recruitment of the interleukin-1 receptor-associated kinase (IRAK) complex via TIR-containing adapter molecules. We describe three unrelated children with inherited IRAK-4 deficiency. Their blood and fibroblast cells did not activate nuclear factor kappaB and mitogen-activated protein kinase (MAPK) and failed to induce downstream cytokines in response to any of the known ligands of TIR-bearing receptors. The otherwise healthy children developed infections caused by pyogenic bacteria. These findings suggest that, in humans, the TIR-IRAK signaling pathway is crucial for protective immunity against specific bacteria but is redundant against most other microorganisms. 相似文献
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Mesmin Xavier Maret Marion Vincent Marie Daniel Loc Gardin Pauline Raitif Julien Faloya Vincent Cortesero Anne-Marie Le Ralec Anne 《Journal of pest science》2022,95(2):653-667
Journal of Pest Science - Natural pest control is a significant service supporting agricultural production. However, the relative contribution of several functional groups of natural enemies to... 相似文献
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Ingrid David Amir Aliakbari Vanille Déru Hervé Garreau Hélène Gilbert Anne Ricard 《Zeitschrift für Tierzüchtung und Züchtungsbiologie》2020,137(6):535-544
Non-genetic information (epigenetic, microbiota, behaviour) that results in different phenotypes in animals can be transmitted from one generation to the next and thus is potentially involved in the inheritance of traits. However, in livestock species, animals are selected based on genetic inheritance only. The objective of the present study was to determine whether non-genetic inherited effects play a role in the inheritance of residual feed intake (RFI) in two species: pigs and rabbits. If so, the path coefficients of the information transmitted from sire and dam to offspring would differ from the expected transmission factor of 0.5 that occurs if inherited information is of genetic origin only. Two pigs (pig1, pig2) and two rabbits (rabbit1, rabbit2) datasets were used in this study (1,603, 3,901, 5,213 and 4,584 records, respectively). The test of the path coefficients to 0.5 was performed for each dataset using likelihood ratio tests (null model: transmissibility model with both path coefficients equal to 0.5, full model: unconstrained transmissibility model). The path coefficients differed significantly from 0.5 for one of the pig datasets (pig2). Although not significant, we observed, as a general trend, that sire path coefficients of transmission were lower than dam path coefficients in three of the datasets (0.46 vs 0.53 for pig1, 0.39 vs 0.44 for pig2 and 0.38 vs 0.50 for rabbit1). These results suggest that phenomena other than genetic sources of inheritance explain the phenotypic resemblance between relatives for RFI, with a higher transmission from the dam's side than from the sire's side. 相似文献
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