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排序方式: 共有1598条查询结果,搜索用时 31 毫秒
111.
Outeiro TF Kontopoulos E Altmann SM Kufareva I Strathearn KE Amore AM Volk CB Maxwell MM Rochet JC McLean PJ Young AB Abagyan R Feany MB Hyman BT Kazantsev AG 《Science (New York, N.Y.)》2007,317(5837):516-519
The sirtuins are members of the histone deacetylase family of proteins that participate in a variety of cellular functions and play a role in aging. We identified a potent inhibitor of sirtuin 2 (SIRT2) and found that inhibition of SIRT2 rescued alpha-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's disease. Genetic inhibition of SIRT2 via small interfering RNA similarly rescued alpha-synuclein toxicity. Furthermore, the inhibitors protected against dopaminergic cell death both in vitro and in a Drosophila model of Parkinson's disease. The results suggest a link between neurodegeneration and aging. 相似文献
112.
Michel E Baglin A Auvergne M Catala C Samadi R Baudin F Appourchaux T Barban C Weiss WW Berthomieu G Boumier P Dupret MA Garcia RA Fridlund M Garrido R Goupil MJ Kjeldsen H Lebreton Y Mosser B Grotsch-Noels A Janot-Pacheco E Provost J Roxburgh IW Thoul A Toutain T Tiphène D Turck-Chieze S Vauclair SD Vauclair GP Aerts C Alecian G Ballot J Charpinet S Hubert AM Lignières F Mathias P Monteiro MJ Neiner C Poretti E de Medeiros JR Ribas I Rieutord ML Cortés TR Zwintz K 《Science (New York, N.Y.)》2008,322(5901):558-560
Oscillations of the Sun have been used to understand its interior structure. The extension of similar studies to more distant stars has raised many difficulties despite the strong efforts of the international community over the past decades. The CoRoT (Convection Rotation and Planetary Transits) satellite, launched in December 2006, has now measured oscillations and the stellar granulation signature in three main sequence stars that are noticeably hotter than the sun. The oscillation amplitudes are about 1.5 times as large as those in the Sun; the stellar granulation is up to three times as high. The stellar amplitudes are about 25% below the theoretic values, providing a measurement of the nonadiabaticity of the process ruling the oscillations in the outer layers of the stars. 相似文献
113.
Russell CA Jones TC Barr IG Cox NJ Garten RJ Gregory V Gust ID Hampson AW Hay AJ Hurt AC de Jong JC Kelso A Klimov AI Kageyama T Komadina N Lapedes AS Lin YP Mosterin A Obuchi M Odagiri T Osterhaus AD Rimmelzwaan GF Shaw MW Skepner E Stohr K Tashiro M Fouchier RA Smith DJ 《Science (New York, N.Y.)》2008,320(5874):340-346
Antigenic and genetic analysis of the hemagglutinin of approximately 13,000 human influenza A (H3N2) viruses from six continents during 2002-2007 revealed that there was continuous circulation in east and Southeast Asia (E-SE Asia) via a region-wide network of temporally overlapping epidemics and that epidemics in the temperate regions were seeded from this network each year. Seed strains generally first reached Oceania, North America, and Europe, and later South America. This evidence suggests that once A (H3N2) viruses leave E-SE Asia, they are unlikely to contribute to long-term viral evolution. If the trends observed during this period are an accurate representation of overall patterns of spread, then the antigenic characteristics of A (H3N2) viruses outside E-SE Asia may be forecast each year based on surveillance within E-SE Asia, with consequent improvements to vaccine strain selection. 相似文献
114.
Long-range correlations in the diffuse seismic coda 总被引:9,自引:0,他引:9
The late seismic coda may contain coherent information about the elastic response of Earth. We computed the correlations of the seismic codas of 101 distant earthquakes recorded at stations that were tens of kilometers apart. By stacking cross-correlation functions of codas, we found a low-frequency coherent part in the diffuse field. The extracted pulses have the polarization characteristics and group velocities expected for Rayleigh and Love waves. The set of cross-correlations has the symmetries of the surface-wave part of the Green tensor. This seismological example shows that diffuse waves produced by distant sources are sufficient to retrieve direct waves between two perfectly located points of observation. Because it relies on general properties of diffuse waves, this result has potential applications in other fields. 相似文献
115.
Wacker M Linton D Hitchen PG Nita-Lazar M Haslam SM North SJ Panico M Morris HR Dell A Wren BW Aebi M 《Science (New York, N.Y.)》2002,298(5599):1790-1793
N-linked protein glycosylation is the most abundant posttranslation modification of secretory proteins in eukaryotes. A wide range of functions are attributed to glycan structures covalently linked to asparagine residues within the asparagine-X-serine/threonine consensus sequence (Asn-Xaa-Ser/Thr). We found an N-linked glycosylation system in the bacterium Campylobacter jejuni and demonstrate that a functional N-linked glycosylation pathway could be transferred into Escherichia coli. Although the bacterial N-glycan differs structurally from its eukaryotic counterparts, the cloning of a universal N-linked glycosylation cassette in E. coli opens up the possibility of engineering permutations of recombinant glycan structures for research and industrial applications. 相似文献
116.
Making the transition from postdoc to independent investigator is tough. Scientists who received prestigious fellowships or grants relate their experiences-and offer some advice. 相似文献
117.
Curran MA van Ommen TD Morgan VI Phillips KL Palmer AS 《Science (New York, N.Y.)》2003,302(5648):1203-1206
The instrumental record of Antarctic sea ice in recent decades does not reveal a clear signature of warming despite observational evidence from coastal Antarctica. Here we report a significant correlation (P < 0.002) between methanesulphonic acid (MSA) concentrations from a Law Dome ice core and 22 years of satellite-derived sea ice extent (SIE) for the 80 degrees E to 140 degrees E sector. Applying this instrumental calibration to longer term MSA data (1841 to 1995 A.D.) suggests that there has been a 20% decline in SIE since about 1950. The decline is not uniform, showing large cyclical variations, with periods of about 11 years, that confuse trend detection over the relatively short satellite era. 相似文献
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