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排序方式: 共有69条查询结果,搜索用时 15 毫秒
51.
Leyenda Harley Cathy Langston 《The Canadian veterinary journal. La revue veterinaire canadienne》2012,53(6):631-638
Proteinuria is defined as the presence of protein in the urine. Normally, circulating serum proteins are blocked by the glomerulus due to size and/or charge. Any small proteins that pass through a healthy glomerulus are reabsorbed by the renal tubules or broken down by renal tubular epithelial cells. Persistent proteinuria, in the absence of lower urinary tract disease or reproductive tract disease, is usually an indication of renal damage or dysfunction. Less commonly persistent proteinuria can be caused by increased circulating levels of low molecular weight proteins. This article reviews mechanisms of proteinuria in dogs and cats and discusses the importance of screening for and ultimately treating proteinuria. 相似文献
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53.
Mullins KB Thomason JM Lunsford KV Pinchuk LM Langston VC Wills RW McLaughlin RM Mackin AJ 《Veterinary anaesthesia and analgesia》2012,39(2):206-217
ObjectiveTo determine effects of anti-inflammatory doses of COX-2 selective NSAIDs carprofen, meloxicam, and deracoxib on platelet function in dogs and urine 11-dehydro-thromboxane B2.Study designRandomized, blocked, crossover design with a 14-day washout period.AnimalsHealthy intact female Walker Hounds aged 1–6 years and weighing 20.5–24.2 kg.MethodsDogs were given NSAIDs for 7 days at recommended doses: carprofen (2.2 mg kg?1, PO, every 12 hours), carprofen (4.4 mg kg?1, PO, every 24 hours), meloxicam (0.2 mg kg?1, PO, on the 1st day then 0.1 mg kg?1, PO, every 24 hours), and deracoxib (2 mg kg?1, PO, every 24 hours). Collagen/epinephrine and collagen/ADP PFA-100 cartridges were used to evaluate platelet function before and during and every other day after administration of each drug. Urine 11-dehydro-thromboxane B2 was also measured before and during administration of each drug.ResultsAll NSAIDs significantly prolonged PFA-100 closure times when measured with collagen/epinephrine cartridges, but not with collagen/ADP cartridges. The average duration from drug cessation until return of closure times (collagen/epinephrine cartridges) to baseline values was 11.6, 10.6, 11 and 10.6 days for carprofen (2.2 mg kg?1 every 12 hours), carprofen (4.4 mg kg?1 every 24 hours), meloxicam and deracoxib, respectively.Conclusions and clinical relevanceOral administration of some COX-2 selective NSAIDs causes detectable alterations in platelet function in dogs. As in humans, PFA-100 collagen/ADP cartridges do not reliably detect COX-mediated platelet dysfunction in dogs. Individual assessment of platelet function is advised when administering these drugs prior to surgery, particularly in the presence of other risk factors for bleeding. 相似文献
54.
Michelle M. Steen-Adams David J. Mladenoff Nancy E. Langston Feng Liu Jun Zhu 《Landscape Ecology》2011,26(8):1165-1178
Landscape ecology studies have demonstrated that past modifications of the landscape frequently influence its structure, highlighting
the utility of integrating historical perspectives from the fields of historical ecology and environmental history. Yet questions
remain for historically-informed landscape ecology, especially the relative influence of social factors, compared to biophysical
factors, on long-term land-cover change. Moreover, methods are needed to more effectively link history to ecology, specifically
to illuminate the underlying political, economic, and cultural forces that influence heterogeneous human drivers of land-cover
change. In northern Wisconsin, USA, we assess the magnitude of human historical forces, relative to biophysical factors, on
land-cover change of a landscape dominated by eastern white pine (Pinus strobus L.) forest before Euro-American settlement. First, we characterize land-cover transitions of pine-dominant sites over three
intervals (1860–1931; 1931–1951; 1951–1987). Transition analysis shows that white pine was replaced by secondary successional
forest communities and agricultural land-covers. Second, we assess the relative influence of a socio-historical variable (“on-/off-Indian
reservation”), soil texture (clay and sand), and elevation on land-cover transition. On the Lake Superior clay plain, models
that combine socio-historical and biophysical variables best explain long-term land-cover change. The socio-historical variable
dominates: the magnitude and rate of land-cover change differs among regions exposed to contrasting human histories. Third,
we developed an integrative environmental history-landscape ecology approach, thereby facilitating linkage of observed land-cover
transitions to broader political, economic, and cultural forces. These results are relevant to other landscape investigations
that integrate history and ecology. 相似文献
55.
Lisa A. Keno DVM DACVIM Cathy E. Langston DVM DACVIM 《Journal of Veterinary Emergency and Critical Care》2011,21(4):363-368
Objective – To describe the successful treatment of accidental ethanol intoxication with hemodialysis in a dog. Case Summary – A 1.5‐year‐old female intact mixed breed dog was presented in a comatose state believed to be due to ethanol intoxication. The initial 9 hours of supportive care treatment were complicated by multiple seizures and hypothermia, and resulted in only minimal improvement in the dog's level of consciousness. Hemodialysis was implemented and resulted in rapid clinical recovery, corresponding to a rapid decline in serum ethanol concentration. New or Unique Information Provided – To the authors' knowledge, this is the first reported case of using hemodialysis to treat accidental ethanol intoxication in a dog. The patient's initial serum ethanol concentration was higher than those previously reported for cases of accidental ethanol intoxication in dogs, and the serum ethanol concentration was shown to rapidly decline during hemodialysis. Treatment with hemodialysis for severe ethanol intoxication was effective in this case and may be able to decrease morbidity and mortality in some cases. 相似文献
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Stanley SW Langston CE 《The Canadian veterinary journal. La revue veterinaire canadienne》2008,49(1):63-66
A 3 1/2-year-old Labrador retriever being presented for acute onset vomiting and lethargy was diagnosed with acute renal failure (ARF). The dog had ingested dried currants, a type of raisin. Hemodialysis was successfully performed to treat the ARE Raisin toxicity can cause ARF and warrants early recognition and aggressive treatment. 相似文献
58.
Meropenem synovial fluid concentrations after intravenous regional limb perfusion in standing horses 下载免费PDF全文
59.
Cathy E Langston Kerry J Heuter 《Veterinary Clinics of North America: Small Animal Practice》2003,33(4):791-807
Leptospirosis is a re-emerging infectious disease that occurs in dogs in urban and rural environments. It is caused by a filamentous spiral bacterium that has a predilection for renal tubules. Acute renal failure, hepatic dysfunction, and hemorrhagic diathesis are the most common clinical signs. Treatment with antibiotics and supportive care can manage a high percentage of cases successfully. Newer vaccines developed in response to the change in frequency of certain serovars may decrease the incidence of clinical disease. Leptospirosis affects a wide variety of species and is zoonotic. 相似文献
60.
Reorganization of retinotopic cortical maps in adult mammals after lesions of the retina 总被引:23,自引:0,他引:23
J H Kaas L A Krubitzer Y M Chino A L Langston E H Polley N Blair 《Science (New York, N.Y.)》1990,248(4952):229-231
The organization of the visual cortex has been considered to be highly stable in adult mammals. However, 5 degrees to 10 degrees lesions of the retina in the contralateral eye markedly altered the systematic representations of the retina in primary and secondary visual cortex when matched inputs from the ipsilateral eye were also removed. Cortical neurons that normally have receptive fields in the lesioned region of the retina acquired new receptive fields in portions of the retina surrounding the lesions. The capacity for such changes may be important for normal adjustments of sensory systems to environmental contingencies and for recoveries from brain damage. 相似文献