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排序方式: 共有137条查询结果,搜索用时 15 毫秒
1.
Ibrahim Ozan Tekeli Erdinc Turk Duygu Durna Corum Orhan Corum Fatma Ceren Kirgiz Kamil Uney 《Journal of veterinary pharmacology and therapeutics》2020,43(5):435-439
The objective of this study was to determine the pharmacokinetics of tolfenamic acid (TA) following intravenous (IV) administration at doses of 2 and 4 mg/kg in goats. In this study, six healthy goats were used. TA was administered intravenously to each goat at 2 and 4 mg/kg doses in a cross-over pharmacokinetic design with a 15-day washout period. Plasma concentrations of TA were analyzed using the high performance liquid chromatography with ultraviolet detector, and pharmacokinetic parameters were assigned by noncompartmental analysis. Following IV administration at dose of 2 mg/kg, area under the concentration–time curve (AUC0−∞), elimination half-life (t1/2ʎz), total clearance (ClT) and volume of distribution at steady state (Vdss) were 6.64 ± 0.81 hr*µg/ml, 1.57 ± 0.14 hr, 0.30 ± 0.04 L h-1 kg-1 and 0.40 ± 0.05 L/kg, respectively. After the administration of TA at a dose of 4 mg/kg showed prolonged t1/2ʎz, increased dose-normalized AUC0-∞, and decreased ClT. In goats, TA at 4 mg/kg dose can be administered wider dose intervals compared to the 2 mg/kg dose. However, further studies are needed to determine the effect of different doses on the clinical efficacy of TA in goats. 相似文献
2.
In a study carried out during 2002 and 2004 in Diyarbakıir and Mardin provinces, southeast Turkey, specimens were collected
twice a month from cultivated and non-cultivated plants. Sixteen leafminer (Diptera: Agromyzidae) species were identified.
Among them,Agromyza abiens Zetterstedt, 1848;Napomyza elegans (Meigen, 1830);Phytoliriomyza dorsata (Siebke, 1864); andPhytomyza aquilonia Frey, 1964 are new records for the Turkish leafminer
http://www.phytoparasitica.org posting July 24, 2005. 相似文献
3.
Fidan I Yesilyurt E Gurelik FC Erdal B Imir T 《Comparative immunology, microbiology and infectious diseases》2008,31(6):467-475
Salmonella typhi (S. typhi) is an important pathogen which causes typhoid fever. The cytokines released from the macrophages, playing a role in the host defense against Salmonella infection, are crucial in the defense against the infection. IFN-γ provides a protection against Salmonella infection by developing macrophage activation in different mechanisms. This study was designed to investigate the effect of the recombinant IFN-γ (rIFN-γ) on the cytokines secreted from S. typhi stimulated macrophages. Macrophage isolation was done in the heparinized blood samples obtained from healthy people, and following the priming with rIFN-γ for 72 h the cells were stimulated by S. typhi and then the cytokine levels in culture supernatants were determined by enzyme-linked immunosorbent assay. It was observed that rIFN-γ reversely increased the levels of IL-1, IL-2 the levels of which were decreased by S. typhi and that it increased TNF-α levels while suppressing the levels of antiinflammatory cytokines such as IL-10 and TGF-β the levels of which were increased by S. typhi. Consequently, rIFN was observed to increase protective Th1 response by affecting the secretion of cytokine during S. typhi infection and it was considered to be a good target especially to prevent and treat invasive Salmonella infections. 相似文献
4.
Luo Y Sahin O Dai L Sippy R Wu Z Zhang Q 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2012,74(5):591-596
Loop-mediated isothermal amplification (LAMP) assay is a simple, rapid and specific detection method and has been used for detection and identification of different Campylobacter species. In this study, we develop a LAMP assay specific for detection of a particular clone (clone SA) of Campylobacter jejuni, associated with the vast majority of recent sheep abortions in the U.S. Using a set of specific primers for C. jejuni IA3902 (a clone SA isolate) and genomic DNA or boiled cell extract as template, the target DNA was amplified at 63 °C for 50 min in a water bath. A positive reaction was identified visually as white precipitate or fluorescence under UV, and confirmed by gel electrophoresis. Detection limit of the assay was comparable to that of conventional PCR. The LAMP was shown to be specific for detection of clone SA when tested on a number of C. jejuni strains of different genetic backgrounds. Applicability of the LAMP assay for specific detection of clone SA was demonstrated in animal tissues experimentally infected with IA3902 or genetically diverse C. jejuni strains. Since clone SA is the predominant cause of sheep abortions in the U.S. and is a zoonotic pathogen, the LAMP assay may be a valuable detection tool in future epidemiological studies. 相似文献
5.
The hypothesis that the presence of fish farming zones affects the water quality and plankton communities was investigated in an Aegean Sea fish farm during February, June, September and January 2000–2001. In the spatial coverage, a total of 12 stations were sampled; three of them were reference stations. A variance analysis was applied to the measurements made at the stations near the fish farms and at the control stations. While no significant differences in concentrations of nutrients, chlorophyll a, particulate organic carbon and particulate organic nitrogen were detected between the stations and the control sites within one season, significant differences were detected between the parameter values measured except for total dissolved phosphorus and dissolved organic phosphorus at different seasons. The seasonal differences were also significant with regard to the biodiversity. Together with these temporal differences in general, there was a higher diversity of species at the control site as compared with the other stations in September, which was the key season to detection of significant changes. The most important consideration is that it is not sufficient to take the instantaneous values for the physico‐chemical variables; rather, it is necessary to monitor the biological parameters in order to define the differences in the ecosystem. 相似文献
6.
Assessment of Biogas use as an Energy Source from Anaerobic Digestion of Brewery Wastewater 总被引:1,自引:0,他引:1
Bahar Kasapgil Ince Orhan Ince G. Ken Anderson Semiha Arayici 《Water, air, and soil pollution》2001,126(3-4):239-251
Energy recovery from a crossflow ultrafiltration (UF) membraneunit employed in order to improve the performance of an anaerobic contact digester for the treatment of brewery wastewater was assessed. The performance of the pilot-scale anaerobic UF membrane system was studied for over 15 months. At steady-state conditions, an organic loading rate of 28.5 kg COD m-3 d-1, a hydraulic retention time of 4.2 days and overall COD and BOD removal efficiencies of 99% and almost 100% were achieved, respectively. Percent methane in biogas was found to be in a range of 67–79% with the corresponding methane yield of 0.28–0.35 m3 CH4 kg-1 CODremoved. The potential energy recovery from the system treating brewery wastewater at an OLR of 28.5 kg COD m-3 d-1 was 87 MJ d-1 which would enable to maintain all energy requirements of the feed pump, mixing and heating of the reactor contents. In addition to this, 71% of the energy requirement for recirculating the reactor content through the membranes would also be recovered. 相似文献
7.
Tevfik Ozen Hamdi Zenginbal Emine Yazicioglu Fatih Gul Ibrahim Demirtas 《International Journal of Fruit Science》2019,19(2):115-135
The present work was conducted to find the physicochemical properties, chemical components and antioxidant capacity of kiwifruit hydroalcoholic extracts (B-31, HO-1-14, J-242, Bruno, Greenlight, Hayward, Monty, Topstar) grown Yalova, Turkey. Phytochemical tests were performed to determine total phenolic, flavonoid and ascorbic acid. Moreover, the kiwifruit extracts were subjected to evaluate their antioxidant potential using different in vitro assays such as total antioxidant, inhibition of lipid peroxidation, reducing power, metal chelating, free radical, H2O2 and superoxide anion scavenging activities at 50–500 μg mL?1, and also found EC50 and IC50 values. The soluble solid content (SSC), titratable acidity (TA) and pH were analyzed in all the genotypes and cultivars. The highest total phenolic, flavonoid and ascorbic acid content were found in J-242 (89.53 mg GAE/100 g), J-242 (109.13 mg QE/100 g) and HO-1-14 (64.15 mg/100 g), respectively. The linoleic, palmitic, stearic and oleic acid methyl esters were detected in all kiwifruit extracts by GC/MS. Significant differences were found between genotypes and cultivars in the antioxidant tests. The extracts showed high inhibition of lipid peroxidation and compared to standards, significantly (p < 0.05). The GC/MS analyses confirmed quantitative variability in the antioxidant profiles. The SSC, TA and pH of kiwifruit genotypes and cultivars showed a moderate level. The key parameters for the most active kiwifruit included the following: total antioxidant activity for B-31, H2O2 scavenging activity for J-242 and metal chelating activity for Topstar. In conclusion, this study exhibited the important role played by the genotypes and cultivars background on the chemical content and antioxidant profiles. 相似文献
8.
Hilal Yildiz Sezai Ercisli Memnune Sengul Elif Feyza Topdas Omer Beyhan Ozlem Cakir Haluk Kemal Narmanlioglu Emine Orhan 《Erwerbs-Obstbau》2014,56(4):123-129
Increasing consumer demands for indigenous, non-sprayed with pesticides and less-known or “forgotten” fruits necessitate knowledge on their breeding, cultivation, biochemical content, harvesting and marketing. Anatolia is rich for wild edible fruit species and barberry is abundant throughout Anatolia. The aim of this study was to determine some important physicochemical characteristics, bioactive content and antioxidant capacity of fruits from nineteen promising barberry (Berberis vulgaris L.) genotypes grown in the Coruh valley, Northeastern Anatolia. The results indicated genotype-specific differences for most of the physicochemical characteristics, antioxidant capacity and the content of some bioactive compounds. Fruit mass ranged from 0.073 (‘Coruh-7’) to 0.267 g (‘Coruh-11’). Total phenolic content ranged from 2532 (‘Coruh-’) to 3719 mg GAE per liter fruit juice (‘Coruh-11’). The genotype ‘Coruh-12’ had the highest total monomeric anthocyanin content (1004 mg per liter fruit juice) as cyanidin-3-glucoside. The highest total antioxidant capacity was observed in fruits of ‘Coruh-8’ and ‘Coruh-9’ genotypes with all three antioxidant-determining methods. We conclude that the barberry fruits represent a good source of bioactive phytochemicals because of their high phenolic and anthocyanin contents. 相似文献
9.
Serhat Türkmen Orhan Tufan Eroldoğan Hatice Asuman Yılmaz Abdüllatif Ölçülü Gül Ayten Kiriş Inan Zeynep Erçen Nazmi Tekelioğlu 《Aquaculture Research》2012,43(11):1643-1650
The compensatory growth response of the European sea bass (Dicentrarchus labrax) that faced cycling starvation and restricted ration was assessed. Juveniles (10.5 g) were stocked into 15 tanks at a density of 25 fish per tank. Five different feeding regimes were tested on triplicate groups of fish: CSatiation: control fed for 60 days without deprivation, CRestricted: 25% restricted feeding, S‐R: 1 day starvation then 4 days CRestricted feeding, R‐F: 1 day CRestricted feeding then 4 days CSatiation feeding, and, finally, S‐F: 1 day starvation then 4 days CSatiation feeding. The specific growth rate of fish in the CSatiation (2.5 ± 0.06% day?1), S‐F (2.5 ± 0.11% day?1) and R‐F (2.4 ± 0.18% day?1) were significantly higher than that of CRestricted (2.2 ± 0.05% day?1) or S‐R (2.0 ± 0.01% day?1). Fish in S‐F group were able to achieve catching up with the CSatiation. There was no significant difference in feed conversion rates but R‐F and S‐F consumed approximately 34% more feed than CSatiation following the first re‐feeding day. Although, the highest lipid content was observed in CSatiation (14.4%), S‐R (33.3% dry matter) had the highest water content compared with the CSatiation and CRestricted (37.8% and 36.9% dry matter respectively). In conclusion, it may be concluded that sea bass has rapid response to cycling starvation/re‐feeding and that a 25% restricted feeding ratio is insufficient to invoke a compensatory growth response in sea bass. 相似文献
10.
Menşure Özgüven Bilge Şener Ilkay Orhan Nazım Şekeroğlu Muzaffer Kirpik Murat Kartal Ipek Peşin Zülküf Kaya 《Industrial Crops and Products》2008,27(1):60-64
Artemisia annua L. is an aromatic-antibacterial herb that destroys malarial parasites, lowers fevers and checks bleeding, and of which the secondary compound of interest is artemisinin. The objective of the present study was to determine yield, yield components and artemisinin content of A. annua L. grown under four nitrogen applications (0, 40, 80 and 120 kg ha−1) in the Çukurova region of Turkey in 2004 and 2005. Field trials were conducted at Çukurova University, Agricultural Faculty Field Crops Department. In the study, plant height, number of branches, fresh herbage yield, dry herbage yield, fresh leaf yield, dry leaf yield, essential oil content and artemisinin content (by high performance liquid chromatography, HPLC) were examined. By analysis of variance, nitrogen doses had no any statistical effect on the traits investigated except for artemisinin content. Artemisinin content of the dried leaves were significantly affected by nitrogen applications, which varied from 6.32 to 27.50 mg 100 g−1. Contents were from 120 and 80 kg ha−1 nitrogen for the years of 2004 and 2005, respectively. 相似文献