排序方式: 共有79条查询结果,搜索用时 15 毫秒
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Daiki KATO Mariko OISHI Koichi OHNO Ko NAKASHIMA Atsuhito WADA Tatsushi MORITA Soichi IMAI Masaya TSUBOI James K. CHAMBERS Kazuyuki UCHIDA Hajime TSUJIMOTO 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(11):1499-1502
Ollulanus tricuspis is a small nematode parasite of the
stomach, and its infection has been reported worldwide in cats but only one report in dogs
as post-mortem diagnosis. Two dogs, kept in the Tokyo area, were presented for chronic
vomiting. Chronic gastritis was diagnosed histologically, and many nematodes were detected
in endoscopically-biopsied gastric samples and in the mucus of vomitus in both dogs. The
parasites were small (<1 mm), and their morphological characteristics were consistent
with those previously reported for O. tricuspis. The symptoms in one dog
completely disappeared after anthelmintic therapy. To our knowledge, this is the first
report describing ante-mortem diagnosis of spontaneous gastric O.
tricuspis infection in dogs in which infectivity and pathogenicity of the
nematode are suggested. 相似文献
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Kei WATARI Satoru KONNAI Tomohiro OKAGAWA Naoya MAEKAWA Yamato SAJIKI Yukinari KATO Yasuhiko SUZUKI Shiro MURATA Kazuhiko OHASHI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2022,84(1):6
Our previous studies demonstrate the therapeutic efficacy against bovine diseases of an anti-bovine programmed death-ligand 1 (PD-L1) chimeric antibody. In humans, PD-1 and PD-L1 antibodies are more effective when combined with an antibody targeting cytotoxic T lymphocyte antigen 4 (CTLA-4) and these combination therapies are therefore clinically used. Here we generated an anti-bovine CTLA-4 chimeric antibody (chAb) to enhance the therapeutic efficacy of the PD-L1 antibody. We further analyzed the effects of dual blockade of CTLA-4 and PD-1 pathways on T-cell responses. The established anti-bovine CTLA-4 chAb showed comparable blocking activity on the binding of bovine CTLA-4 to CD80 and CD86 as the anti-bovine CTLA-4 mouse monoclonal antibody. Anti-bovine CTLA-4 chAb also significantly increased IL-2 production from bovine peripheral blood mononuclear cells (PBMCs). Further, the combination of anti-CTLA-4 chAb with anti-PD-L1 chAb significantly upregulated IL-2 production by PBMCs. These results suggest that the combination of antibodies have higher potential to enhance immune responses against pathogens compared with single administration. 相似文献
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云南稻种冲腿的孕穗期耐冷性QTL分析 总被引:24,自引:6,他引:24
利用352 个探针分析了日本品种农林20和云南品种冲腿之间的限制性片段长度多态性(RFLP),从中筛选出157个在农林20和冲腿间显示多态性的探针,其中55个被用于其杂交后代(农林20/冲腿)的70个F3系统的孕穗期耐冷性数量性状位点(QTL)分析。结果初步显示出一些与水稻孕穗期耐冷性有关的QTL,它们主要分布在第1、3、4、5、6、7、8、10和第12染色体上。可能在第3和第7染色体上具有对孕穗期耐冷性作用较大的QTL。 相似文献
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Hiroko SHIBATA Natsuko HASHIZUME Masudur R. GAZI Kenji SERA Eisei KATO Toshihiro OHMORI Michio KANBE Yoshiaki OBARA Shuhei KANDA Hisao ITABASHI 《Animal Science Journal》2011,82(4):554-559
Eight cows were used to evaluate the effects of supplementation of soy sauce oil (SO) or Ca salts of fatty acids (FA) on rumen fermentation and milk production. The control diet (CO) consisted mainly of hay, corn silage and a concentrate. In the experimental diets, 400 g/day per cow of SO or FA (soybean oil and rapeseed oil) was supplemented to the CO diet. Experimental period for the three treatments was 14 days, and milk samples were taken during the last 2 days and rumen sample was taken on the last day. Dry matter intake was not affected by the treatments. The number of rumen protozoa at 0 h increased by SO and FA diets. Total volatile fatty acids at 2 h after feeding of SO diet was decreased compared to CO. The milk composition yield did not differ among treatments, although the percentages of fat and protein were decreased by SO and FA diets. The proportions of C8–C16 fatty acids in milk fat decreased, and those of C18 increased by SO and FA diets. The proportion of cis‐9, trans‐11 conjugated linoleic acid in milk fat by SO and FA diets increased by 120% and 135%, respectively. In spite of the slight suppression of rumen fermentation by SO diet, negative effects on feed intake and milk production were not detected. 相似文献
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Natsumi SHIMIZU Kimihiro UENO Ena KURITA Seung-Wook SHIN Takuji NISHIHARA Tomoko AMANO Masayuki ANZAI Satoshi KISHIGAMI Hiromi KATO Tasuku MITANI Yoshihiko HOSOI Kazuya MATSUMOTO 《The Journal of reproduction and development》2014,60(3):179-186
In the mammalian testis, the ubiquitin-proteasome system plays important roles in the process that promotes the formation of
mature sperm. We recently identified zygote-specific proteasome
assembly phaperone (ZPAC), which is specifically expressed in the mouse
gonads and zygote. ZPAC mediates a unique proteasome assembly pathway in the zygote, but the expression profile and function
of ZPAC in the testis is not fully understood. In this study, we investigated the possible role of ZPAC during mouse
spermatogenesis. First, we analyzed the expression of ZPAC and 20S proteasome subunit α4/PSMA7 in the adult mouse testis.
ZPAC and α4 were expressed in spermatogonia, spermatocytes, and round spermatids. In elongating spermatids, ZPAC was
expressed until step 10, whereas expression of α4 persisted until step 12. We then examined the expression profile of ZPAC
and α4 in a mouse model of experimental unilateral cryptorchidism. Consistent with appearance of morphologically impaired
germ cells following cryptorchidism, the ZPAC protein level was significantly decreased at 4 days post induction of
experimental cryptorchidism (D4) compared with the intact testis, although the amount of α4 protein persisted at least until
D10. Moreover, intense ZPAC staining was co-localized with staining of annexin V, an early indicator of apoptosis in
mammalian cells, in germ cells of cryptorchid testis, but ZPAC was also expressed in germ cells showing no detectable
expression of annexin V. These results suggest that ZPAC plays a role during spermatogenesis and raises the possibility that
20S proteasome mediated by ZPAC may be involved in the regulation of germ cell survival during spermatogenesis. 相似文献