Tumour necrosis factor stimulated gene 6 intrinsically regulates PD-L1 expressions in breast cancer cells,leading to modulation of tumour microenvironment

Recent studies have shown that tumour cells express tumour necrosis factor-inducible gene 6 (TSG-6) and its protein, which is known to play a key role in regulating excessive immune responses and proliferation and growth of mesenchymal stem cells (MSCs). It has not been confirmed whether the inhibition of TSG-6 for tumour cells can suppress tumour cell growth and regulate the activation of immune cells in the tumour microenvironment (TME). TSG-6-specific small interfering RNA was transfected into canine and human breast cancer cells (CIPp, CIPm and BT-20). TSG-6-down-regulated (siTSG-6) cells showed decreased cell proliferation, migration, and invasion abilities. Decreased mRNA expressions of NF-κB, STAT3 and Sox2, confirming that TSG-6 is an upper factor governing tumour growth and metastasis. Notably, siTSG-6 cells showed significantly decreased expression levels of CD44 and PD-L1. Direct and indirect co-culture of canine peripheral blood mononuclear cells (cPBMCs) and the siTSG-6 cells showed significant activation in M1 type macrophages and cytotoxic T cells. They also showed a tendency to decrease in the expression of CTLA-4 and increase in the expression of PD-1. In conclusion, this study suggests that the down-regulation of TSG-6 in breast cancer cells could not only suppress tumour growth and metastasis, and but also regulate TME. Since modulation of immune checkpoint proteins occurs in both tumour cells and immune cells, inhibiting TSG-6 and its protein within the TME could be novel therapeutic target for anticancer treatment.     

A Furry Synthetic Evaluation Model in Capital Structure Decisions

This paper analyzes the limitation of regarding the weighted average cost of capital as the optimal standard of capital structure in the traditional capital structure decision-making method, and analyzes the view that the capital structure is affected by many factors,such as earning power, long-term stability of operating, the attitudes held by owners and operators, the attitudes held by creditors and financial risk. With the example, the affecting factors of the capital structure is analyzed. The fuzzy synthetic evaluation model are employed to decision-making of the capital structure. This article also shows the key point of its application.     

Knowledge-based Intelligent Decision-making System for the Safety of Rockets

With the progress of science and technology, the astronautics has obtained great development and researched in many countries, the problem on rocket safety control is important during the rocket launching proceeding, and is also the focus of every space country. At first, the importance of rocket safety control is introduced and the characteristics of the existing system for the safety of rockets are analyzed. After indicating its disadvantages, the design idea, system framework and method for realization of the knowledge-based intelligent decision-making system are proposed to improve certainty and authenticity of safety decision, containing correspond knowledge and adopting the technology of intelligent decision and reasoning on AI.     

Accomplishment of Elastic-plastic Analysis in Geotechnical FEA

In order to realize elastic-plastic analysis in geotechnical FEA, in this paper, firstly, the method how to realize elastic-plastic analysis in Super-Sap is discussed. Then, this paper stresses to introduce the principle and the steps used to achieve the accomplishment of elastic-plastic analysis in Super-Sap. Finally, an engineering practice is given to prove that the geotechnical FEA elastic-plastic analysis and visualized post-processing can come true by it rapidly.     

A STUDY ON HEAT AND MOISTURE STATE OF HULL LAYER FOR THERMAL INSTULATION OF A COLD STORAGE

This paper analyses the thermal moist characteristics of the hull layer beside an air layer at lower temperature in an envelope for a cold storage and presents a new method of waterproof by air layer. With test data from engineering practice, the theory on the barrier of self moisture proof at the surface sublayer of the hull layer in an attic on a cold storage is proven. The dried zone about three phase point is confirmed. It is a new knowledge for thermophysics on thermal design of a cold storage with an optimum thermal performance.     

Irrigated land retirement

Land retirement is ceasing irrigation withthe goal of reducing load, in general, ofdissolved constituents and, in particular,of trace elements, present in subsurfacedrainage generated from irrigated lands. Retirement is achieved through a process ofgoal setting, strategy development anddetermining effects, developing landselection criteria, implementation, andmonitoring. In this study, effects of landretirement are evaluated using hydrologic,soil and economic models as well as resultsfrom a field demonstration study. From themodeling and field monitoring, a process isdeveloped to meet the goals of a landretirement program in the San JoaquinValley of California.Potential negative effects listed for landretirement included loss of agriculturalproductivity, perhaps permanently, and lossof revenue to surrounding communities. Uncertainties included those associatedwith reuse of retired lands as wildlifehabitat, with retired-land maintenanceincluding dust control, with potentialpreservation of retired lands in reservefor future re-introduction to irrigated ordry-land agriculture, and withinstitutional changes concerning repaymentof federal and state water contracts. Benefits would accrue from economic returnto the landowner from the sale of property,the sale or lease of irrigation watersupply, the reduced cost of handlingdrainage, and allocation of freed-up waterto beneficial uses, and the reduced risk ofselenium exposure to fish and wildlife.A recommended sequential approach to selectand manage retired land is to identifyprimary objectives; formulate and implementarea-specific land retirement scenarios;measure biologic, hydrologic, soils andeconomic consequences in the short term andthe long term and manage and monitorretired lands based on dynamic biologic,hydrologic and soil conditions.     

快速环路分解遗传算法在配电网络重构中的应用

为了有效提高配电网络的收敛速度，避免不成熟收敛，在传统遗传算法的基础上，提出了一种快速环路分解遗传算法。提出用支路的开关状态(0或1)作为控制参数，避免繁琐的编码方法，缩短了染色体的长度，同时对交叉位置的选取和变异提出了独特的方案，并用于网络重构中，极大地提高了计算效率。     

Evaluating evaporation from field crops using airborne radiometry and ground-based meteorological data

Summary Airborne measurements of reflected solar and emitted thermal radiation were combined with ground-based measurements of incoming solar radiation, air temperature, windspeed, and vapor pressure to calculate instantaneous evaporation (LE) rates using a form of the Penman equation. Estimates of evaporation over cotton, wheat, and alfalfa fields were obtained on 5 days during a one-year period. A Bowen ratio apparatus, employed simultaneously, provided ground-based measurements of evaporation. Comparison of the airborne and ground techniques showed good agreement, with the greatest difference being about 12% for the instantaneous values. Estimates of daily (24 h) evaporation were made from the instantaneous data. On three of the five days, the difference between the two techniques was less than 8%, with the greatest difference being 25%. The results demonstrate that airborne remote sensing techniques can be used to obtain spatially distributed values of evaporation over agricultural fields.     

中国省域核桃产业竞争力评价

核桃作为中国重要的木本油料产业之一,在发挥生态保护、促进贫困地区经济发展、实现我国乡村振兴战略等方面发挥着重要作用.科学评价中国各省(市、自治区)核桃产业竞争力对明确地区核桃发展劣势、巩固竞争优势、合理制定产业未来发展战略具有重要意义.基于核桃生产及消费相关静态统计年鉴数据,采用熵值法和因子分析法,从基本竞争力、生产竞争力、市场竞争力、技术竞争力4个方面对中国18个主要核桃种植省市区进行核桃产业竞争力综合评价.结果 表明:以云南、新疆、四川、北京、山东为代表的区域,核桃产业竞争力最强,应充分发挥其资源优势,加快科技创新,提高当地核桃产业化程度;以浙江、河南、山西、陕西、河北为代表的区域,核桃产业竞争力较强,应在产业规模的基础上,重点发展第二产业,推动核桃产业转型升级;以重庆、安徽、湖南、湖北、甘肃、贵州、吉林、西藏为代表的区域,核桃产业竞争力最弱,应进一步发挥核桃产业发展潜力,以优质产品取胜.     

Ultrasound-Assisted Extraction for the Recovery of Carotenoids from Guava’s Pulp and Waste Powders

Plant Foods for Human Nutrition - In this work, lycopene- and β-carotene-rich extracts were obtained from guava’s pulp and waste powders using maceration (ME), ultrasonic bath (BUAE,...