排序方式: 共有35条查询结果,搜索用时 15 毫秒
31.
Brianza S Brighenti V Lansdowne JL Schwieger K Bouré L 《Veterinary journal (London, England : 1997)》2011,190(2):260-267
The transfixation pin cast (TPC) is an external skeletal fixation technique used to treat horses with distal limb fractures, but its use is often associated with pin-loosening and an increased risk of treatment failure. To address implant loosening, the pin sleeve cast system (PSC) was recently designed and consists of a pin-sleeve unit inserted into the bone. Each pin runs through a sleeve placed in the bone, making contact at two fixed points only within the sleeve. Each pin is attached to a ring embedded in a resin cast. In this report, the mechanical performance of a traditional TPC pin arrangement was compared with that of the PSC using validated finite element models of bone substitutes previously tested in vitro. The PSC resulted in a marked reduction in peak strain magnitude around the pins and a more even distribution of strain across the bone cortex. The two systems resulted in comparable proximal fragment displacement and had a similar stress concentration around bone defects during implant removal. The findings suggest that the PSC load transfer mechanism is effective even in geometrically complex structures like equine bones. 相似文献
32.
Vittoria Castiglioni Marcella De Maglie Roberta Queliti Alessandra Rustighi Giannino Del Sal Enrico Radaelli 《Journal of toxicologic pathology》2013,26(4):423-427
A nephroblastoma is a tumor arising from metanephric blastema occurring in childhood.
Among laboratory rodents, nephroblastoma has been frequently reported in rats, but it
remains exceedingly rare in mice. The present work describes a nephroblastoma in a young
mouse homozygous for the specific Trp53 R172H point mutation coupled with targeted
deletion of the Pin1 gene. The affected kidney was effaced by a biphasic
tumor with an epithelial component arranged in tubules surrounded by nests of blastemal
cells. Immunohistochemically, the neoplasm was diffusely positive for Wilms’ tumor
antigen. The epithelial component expressed markers of renal tubular differentiation
including wide-spectrum cytokeratin, E-cadherin and folate-binding protein. Furthermore,
the neoplasm exhibited a high proliferative index and diffuse nucleocytoplasmic β-catenin
expression. Based on histological and immunohistochemical features, a diagnosis of
nephroblastoma potentially associated with Trp53 loss and oncogenic
β-catenin activation has been proposed. 相似文献
33.
Federica Di Cesare Daniela Gioeni Giuliano Ravasio Alberto Pellegrini Lorena Lucatello Vittoria Bisutti Roberto Villa Petra Cagnardi 《Journal of veterinary pharmacology and therapeutics》2019,42(4):392-400
This study aimed to define the pharmacokinetic profiles of dexmedetomidine and methadone administered simultaneously in dogs by either an oral transmucosal route or intramuscular route and to determine the bioavailability of the oral transmucosal administration relative to the intramuscular one of both drugs, so as the applicability of this administration route in dogs. Twelve client‐owned dogs, scheduled for diagnostic procedures, were treated with a combination of dexmedetomidine hydrochloride (10 μg/kg) and methadone hydrochloride (0.4 mg/kg) through an oral transmucosal route or intramuscularly. Oral transmucosal administration caused ptyalism in most subjects, and intramuscular administration caused transient peripheral vasoconstriction. The results showed reduced and delayed absorption of both dexmedetomidine and methadone when administered through an oral transmucosal route, with median (range) Cmax values of 0.82 (0.42–1.49) ng/ml and 13.22 (2.80–52.30) ng/ml, respectively. The relative bioavailability was low: 16.34% (dexmedetomidine) and 15.5% (methadone). Intramuscular administration resulted in a more efficient absorption profile, with AUC and Cmax values for both drugs approximately 10 times higher. Dexmedetomidine and methadone administered simultaneously by an oral transmucosal route using injectable formulations were not well absorbed through the oral mucosa. Nevertheless, additional studies on these drugs combination using alternative administration routes are recommended. 相似文献
34.
Erin K. Loury Vittoria L. Elliott Shaara M. Ainsley Ian G. Baird Lee J. Baumgartner Samol Chhuoy Dana J. Lee Peng Bun Ngor Bunthang Touch An V. Vu Zeb S. Hogan 《Fisheries Management and Ecology》2021,28(5):393-416
Despite their economic and ecological importance, migratory fishes of the Lower Mekong Basin (LMB) remain understudied, which hampers effective management to sustain valuable fisheries and address serious threats such as habitat degradation, development and overharvest. From a list of potential knowledge needs, a group of fisheries professionals most frequently identified six top priorities for managing migratory fishes in Cambodia: (1) population abundances and trends, (2) life cycles and life history, (3) migration timing and triggers, (4) migration routes and distances, (5) locations of key habitats and spawning areas, and (6) environmental and habitat requirements. These needs are discussed along with nine relevant methodologies for addressing them, including fisheries-dependent and fisheries-independent sampling, reproductive techniques and captive studies, otolith and genetic analysis tools, and tagging and imaging techniques. A suggested research framework is also presented to inform adaptive management of migratory fishes. While emphasis is given to Cambodia, the analysis is also applicable to other LMB countries, given that migratory fishes occur throughout the basin and migrate across borders. It is suggested that a robust research and monitoring agenda is required to prioritise knowledge needs and select appropriate methodologies to answer questions vital to inform sustainable migratory fish management in Cambodia. 相似文献
35.
Gabriella Sonnante Anna Vittoria Carluccio Angelo De Paolis Domenico Pignone 《Genetic Resources and Crop Evolution》2008,55(7):1029-1046
A set of 24 microsatellite markers was identified in the artichoke genome, using various approaches. A genomic library allowed
the development of 14 SSR markers, whereas the other 10 were obtained from gene intron/UTR regions or from other species.
Allelic variation was scored in C. cardunculus (artichoke, cultivated cardoon, and wild cardoon) samples, and in other wild Cynara allies. For the 23 polymorphic loci, a total of 165 alleles were scored, 135 of which in the artichoke primary genepool,
and the remaining ones in the other Cynara species. Some allele combinations were able to identify artichoke varietal types, and some alleles were unique to specific
groups. This makes these markers potentially useful in product traceability and in contributing to the saturation of genetic
maps. The percentage of shared alleles between C. cardunculus taxonomic groups, and Nei’s genetic distances indicated that wild cardoons from the Eastern Mediterranean were more closely
related to artichoke and less to cultivated cardoon in comparison to wild cardoons from the Western Mediterranean, and the
genetic distance between the two wild cardoon genepools was rather high. The UPGMA dendrogram based on Nei’s genetic distances
revealed that artichokes formed a fairly defined cluster, whereas Eastern wild cardoons occupied another branch, and Western
wild cardoons were clustered together with cultivated cardoons. The transferability of microsatellite markers to other Cynara wild species was quite good. Sequencing alleles at three loci showed that, apart from microsatellite length variation, point
mutations and insertion/deletions were quite abundant especially when comparing C. cardunculus to the other Cynara species. In the sequenced regions, some SNPs were identified which distinguished artichoke on one side, and cultivated and
wild cardoon on the other, while other SNPs were apportioned according to the geographic distribution of Cynara wild species. 相似文献