The legitimacy of the agricultural extension service

Traditionally, the Swedish Agricultural Extension Service has delivered technical information to farmers with the aim of increasing productivity and efficiency in farming. Present problems with overproduction of food and the negative social and environmental consequences of present farm practices has brought this traditional mission in question. In a situation of budgetary constraints it has been suggested that the funding of the governmental Agricultural Extension Service should be cut down or even discontinued altogether The article argues that this would be a mistake. The various negative consequences of modern agriculture indicate that we are far from an ideal mode of agricultural production. Instead, public opinion and new guidelines for agricultural and environmental policies call for substantial changes in Swedish agriculture with respect to pollution, preservation of non-renewable resources, maintaining an open rural landscape, ethical aspects of animal production, rural development etc. This reorientation of Swedish agriculture presumes that decision-makers, farmers, and the public at large get an opportunity to learn more about the complexities of agricultural production. In contributing to this learning process the Agricultural Extension Service would have an important mission. To be able to fulfill this mission, extension professionals must be provided an opportunity to learn a broader concept of productivity and efficiency in agriculture, for instance, how to extend cost-benefit analyses and technical criteria of efficiency to include social, environmental, and ethical aspects. Our present extension staff has not received adequate training for this task. It is suggested that all agricultural colleges need to create departments of Rural Sociology and Agricultural Humanities to provide agricultural students and professionals an opportunity to develop a better understanding of agriculture and make them prepared to take on the challenges and responsibilities they confront in developing our future agriculture.     

Inhibition of hepatitis B virus replication by drug-induced depletion of nucleocapsids

Chronic hepatitis B virus (HBV) infection is a major cause of liver disease. Only interferon-alpha and the nucleosidic inhibitors of the viral polymerase, 3TC and adefovir, are approved for therapy. However, these therapies are limited by the side effects of interferon and the substantial resistance of the virus to nucleosidic inhibitors. Potent new antiviral compounds suitable for monotherapy or combination therapy are highly desired. We describe non-nucleosidic inhibitors of HBV nucleocapsid maturation that possess in vitro and in vivo antiviral activity. These inhibitors have potential for future therapeutic regimens to combat chronic HBV infection.