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排序方式: 共有311条查询结果,搜索用时 15 毫秒
101.
Naoaki YAMADA Takashi KITAMORI Fumiyo KITAMORI Kanako ISHIGAMI Koji IWANAGA Taiki ITOU Ryosuke KOBAYASHI Shino KUMABE Takuya DOI Junko SATO Yumi WAKO Minoru TSUCHITANI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(10):1299-1303
A 7-year-old female boxer dog died suddenly without any clinical signs. It was suspected
that the dog had arrhythmogenic right ventricular cardiomyopathy (ARVC) due to ventricular
premature complexes and ventricular tachycardia at 3 years of age. The final diagnosis of
ARVC was confirmed by histological characteristics, such as loss of cardiocytes and
fibrofatty replacement, occurring in the right and left ventricular walls. In the
cardiocytes, non-lipid vacuoles were observed. Cardiac fibrosis and intimal thickening of
the small arteries occurred without fatty replacement in the inner muscle layer including
the papillary muscles of the left ventricular wall. This paper describes the
pathomorphological details of an ARVC case with coincidental cardiac fibrosis in the inner
muscle layer of the left ventricular wall. 相似文献
102.
Intracerebroventricular administration of chicken glucagon‐like peptide‐2 potently suppresses food intake in chicks
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Kazuhisa Honda Takaoki Saneyasu Tomohiko Shimatani Koji Aoki Takuya Yamaguchi Kiwako Nakanishi Hiroshi Kamisoyama 《Animal Science Journal》2015,86(3):312-318
Glucagon‐related peptides, such as glucagon‐like peptide (GLP)‐1, GLP‐2 and oxyntomodulin (OXM), are processed from an identical precursor proglucagon. In mammals, all of these peptides are suggested to be involved in the central regulation of food intake. We previously showed that intracerebroventricular administration of chicken OXM and GLP‐1 significantly suppressed food intake in chicks. Here, we show that central administration of chicken GLP‐2 potently suppresses food intake in chicks. Male 8‐day‐old chicks (Gallus gallus domesticus) were used in all experiments. Intracerebroventricular administration of chicken GLP‐2 significantly suppressed food intake in chicks. Plasma glucose concentration was significantly decreased by chicken GLP‐2, whereas plasma nonesterified fatty acid concentration was significantly increased. Intracerebroventricular administration of chicken GLP‐2 did not affect plasma corticosterone concentration. In addition, the anorexigenic effect of GLP‐2 was not reversed by the corticotropin‐releasing factor (CRF) receptor antagonist α‐helical CRF, suggesting that CRF is not a downstream mediator of the anorexigenic pathway of GLP‐2 in chicks. Intracerebroventricular administration of an equimolar amount of GLP‐1 and GLP‐2, but not OXM, significantly suppressed food intake in both broiler and layer chicks. All our findings suggest that GLP‐2 functions as a potent anorexigenic peptide in the brain, as well as GLP‐1, in chicks. 相似文献
103.
Yoshihiro KOBAYASHI Tetsushi HIRANO Takuya OMOTEHARA Rie HASHIMOTO Yuria UMEMURA Hideto YUASA Natsumi MASUDA Naoto KUBOTA Kiichi MINAMI Shogo YANAI Mitsuko ISHIHARA-SUGANO Youhei MANTANI Toshifumi YOKOYAMA Hiroshi KITAGAWA Nobuhiko HOSHI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(11):1355-1361
104.
Takuya HIROSE Takayuki OGURA Keisuke TANAKA Jun MINAGUCHI Takeshi YAMAUCHI Toshiyuki FUKADA Yoh-ichi KOYAMA Kazushige TAKEHANA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(11):1385-1389
Ehlers-Danlos syndrome (EDS) is a group of disorders caused by abnormalities that are
identified in the extracellular matrix. Transforming growth factor-β1 (TGF-β1) plays a
crucial role in formation of the extracellular matrix. It has been reported that the loss
of function of zinc transporter ZRT/IRT-like protein 13 (ZIP13) causes the spondylocheiro
dysplastic form of EDS (SCD-EDS: OMIM 612350), in which dysregulation of the TGF-β1
signaling pathway is observed, although the relationship between the dermis abnormalities
and peripheral TGF-β1 level has been unclear. We investigated the characteristics of the
dermis of the Zip13-knockout (KO) mouse, an animal model for SCD-EDS.
Both the ratio of dermatan sulfate (DS) in glycosaminoglycan (GAG) components and the
amount of collagen were decreased, and there were very few collagen fibrils with diameters
of more than 150 nm in Zip13-KO mice dermis. We also found that the
TGF-β1 level was significantly higher in Zip13-KO mice serum. These
results suggest that collagen synthesis and collagen fibril fusion might be impaired in
Zip13-KO mice and that the possible decrease of decorin level by
reduction of the DS ratio probably caused an increase of free TGF-β1 in
Zip13-KO mice. In conclusion, skin fragility due to defective
ZIP13 protein may be attributable to impaired extracellular matrix
synthesis accompanied by abnormal peripheral TGF-β homeostasis. 相似文献
105.
Park HS Hohn MJ Umehara T Guo LT Osborne EM Benner J Noren CJ Rinehart J Söll D 《Science (New York, N.Y.)》2011,333(6046):1151-1154
O-Phosphoserine (Sep), the most abundant phosphoamino acid in the eukaryotic phosphoproteome, is not encoded in the genetic code, but synthesized posttranslationally. Here, we present an engineered system for specific cotranslational Sep incorporation (directed by UAG) into any desired position in a protein by an Escherichia coli strain that harbors a Sep-accepting transfer RNA (tRNA(Sep)), its cognate Sep-tRNA synthetase (SepRS), and an engineered EF-Tu (EF-Sep). Expanding the genetic code rested on reengineering EF-Tu to relax its quality-control function and permit Sep-tRNA(Sep) binding. To test our system, we synthesized the activated form of human mitogen-activated ERK activating kinase 1 (MEK1) with either one or two Sep residues cotranslationally inserted in their canonical positions (Sep(218), Sep(222)). This system has general utility in protein engineering, molecular biology, and disease research. 相似文献
106.
107.
Takuya Kawanishi Yoshishige Hayashi Nobuharu Kihou Tadakatsu Yoneyama Yasuo Ozaki 《Soil Science and Plant Nutrition》2013,59(2):407-411
Abstract We previously analyzed the effect of nitrate dispersion on the apparent nitrogen isotope fractionation factor associated with denitrification in soil (Kawanishi et al. 1993), and found that the dispersion effect was significant when the water flow was slow. In the previous report, we assumed that the dispersion coefficients of 14NO3 ? and 15NO3 ? were similar. However, when the water flow is slow, molecular diffusion will dominate mechanical dispersion and the above assumption may not be valid. 相似文献
108.
Volcanogenous soils are widely distributed in Japan. Andosols, a group of volcanogenous soil, are known to show several physicochemical characteristics such as high porosity, presence of allophane, and high content of organic carbon (FitzPatrick 1980). The formation of Andosols is a very rapid process resulting from the large surface area of the volcanic ash-derived parent materials. 相似文献
109.
Masayuki Tani Takuya Okuten Masanori Koike Katsuhisa Kuramochi Renzo Kondo 《Soil Science and Plant Nutrition》2013,59(3):439-446
Nitrate leaching from agricultural lands is one of the most critical problems related to both environmental quality and human health. Although in many studies surfacecharge properties of and nitrate adsorption in soils have been analyzed in tropical and subtropical regions, fewer studies have been conducted on the nitrateretention properties of allo phanic Andisols. The objectives of the present study were to examine the potential nitrate adsorption capacity and the factors affecting nitrate retention in topsoils and subsoils of three Andisols Tokaachi, Hokkaido. Nitrate adsorption at pH 6.0 was found to be low or negligible even in the subsoil of a Haplic Wet Andisol (Melanaquands), despite the high clay content, Nitrate adsorption maxima calculated from the Langmuir equation were higher in the lower horizons of a Haplic Andisol (Melanudands) and a Lowhumic Andisol (Hap ludands), which were developed under moderate to moderately dry moisture conditions and displayed a high allophane content and a low total carbon content. The nitrate adsorption of the aliophanic Andisols was much higher than that reported from other studies conducted in Ultisols and Oxisols, which are rich in iron oxides. The potential capacity to adsorb nitrates and retard nitrate movement should be taken into account in predicting the fate of nitrate in soils and the consequent mitigation of groundwater contamination. 相似文献
110.