Venera 4 probes atmosphere of venus

The atmospheric data and information on trajectory received from Venera 4 together provide consistent and firm evidence of its success in reaching the surface of Venus.     

A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis

The incidence of tuberculosis has been increasing substantially on a worldwide basis over the past decade, but no tuberculosis-specific drugs have been discovered in 40 years. We identified a diarylquinoline, R207910, that potently inhibits both drug-sensitive and drug-resistant Mycobacterium tuberculosis in vitro (minimum inhibitory concentration 0.06 mug/ml). In mice, R207910 exceeded the bactericidal activities of isoniazid and rifampin by at least 1 log unit. Substitution of drugs included in the World Health Organization's first-line tuberculosis treatment regimen (rifampin, isoniazid, and pyrazinamide) with R207910 accelerated bactericidal activity, leading to complete culture conversion after 2 months of treatment in some combinations. A single dose of R207910 inhibited mycobacterial growth for 1 week. Plasma levels associated with efficacy in mice were well tolerated in healthy human volunteers. Mutants selected in vitro suggest that the drug targets the proton pump of adenosine triphosphate (ATP) synthase.     

重新评估母猪妊娠期日粮的纤维营养

养猪生产者有机会通过给妊娠母猪饲喂富含纤维的日粮来维持和改善其繁殖性能。 概述：笔者查阅了1975～2007年发表的24篇报告,以确定给妊娠母猪饲喂高水平纤维型日粮所产生的总体影响。母猪及其产仔性状通过每个试验内各个处理的母猪窝数来权衡。总体而言,母猪妊娠阶段可以安全地采食高纤维日粮,而几乎不会带来的有害影响。母猪采食高水平纤维型日粮后产生的积极影响可明显地反映在窝产仔数（提高0.2～0.6头/窝）和哺乳期的采食量（提高0.5～0.8lb/d）上,但在母猪持续采食高水平纤维型日粮后的第2个繁殖周期前,这些影响并不是非常显著。通过饲喂高水平纤维型日粮,可能有助于确保母猪及其所产仔猪的生产性能得到改善,但纤维类饲料必须在母猪配种之前加入所喂的日粮中。