Dependence of EPSP efficacy on synapse location in neocortical pyramidal neurons

Neurons receive thousands of synaptic inputs throughout elaborate dendritic trees. Here we determine the somatic impact of excitatory postsynaptic potentials (EPSPs) generated at known dendritic sites in neocortical pyramidal neurons. As inputs became more distal, somatic EPSP amplitude decreased, whereas use-dependent depression increased. Despite marked attenuation (>40-fold), when coactivated within a narrow time window (approximately 10 milliseconds), distal EPSPs could directly influence action potential output following dendritic spike generation. These findings reveal that distal EPSPs are ineffective sources of background somatic excitation, but through coincidence detection have a powerful transient signaling role.     

Dynamics of mammalian chromosome evolution inferred from multispecies comparative maps

The genome organizations of eight phylogenetically distinct species from five mammalian orders were compared in order to address fundamental questions relating to mammalian chromosomal evolution. Rates of chromosome evolution within mammalian orders were found to increase since the Cretaceous-Tertiary boundary. Nearly 20% of chromosome breakpoint regions were reused during mammalian evolution; these reuse sites are also enriched for centromeres. Analysis of gene content in and around evolutionary breakpoint regions revealed increased gene density relative to the genome-wide average. We found that segmental duplications populate the majority of primate-specific breakpoints and often flank inverted chromosome segments, implicating their role in chromosomal rearrangement.     

Trench-parallel anisotropy produced by foundering of arc lower crust

Many volcanic arcs display fast seismic shear-wave velocities parallel to the strike of the trench. This pattern of anisotropy is inconsistent with simple models of corner flow in the mantle wedge. Although several models, including slab rollback, oblique subduction, and deformation of water-rich olivine, have been proposed to explain trench-parallel anisotropy, none of these mechanisms are consistent with all observations. Instead, small-scale convection driven by the foundering of dense arc lower crust provides an explanation for the trench-parallel anisotropy, even in settings with orthogonal convergence and no slab rollback.